PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32262965-10 2016 Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions. beta-tricalcium phosphate 17-25 alkaline phosphatase, placental Homo sapiens 65-85 32262965-10 2016 Furthermore, the beta-TCP-Fe-GO scaffolds significantly enhanced alkaline phosphatase (ALP) activity and osteogenic gene expression, such as OPN, Runx2, OCN and BSP, of rabbit bone marrow stromal cells (rBMSCs) and significantly stimulated rBMSCs proliferation as compared to pure beta-TCP scaffolds by the synergistic effect of GO and the released Fe ions. beta-tricalcium phosphate 17-25 alkaline phosphatase, placental Homo sapiens 87-90 23894078-8 2014 The ALP expression, calcium deposition, and ERK1/2 phosphorylation of rBMSCs, which was promoted by ions released from beta-CS/beta-TCP composites, were blocked by an AMPK inhibitor, Compound C. These results indicate that bioactive ions extracted from beta-CS/beta-TCP composites could stimulate the osteogenic differentiation of rBMSCs via the AMPK-Erk1/2 pathway. beta-tricalcium phosphate 127-135 alkaline phosphatase, placental Homo sapiens 4-7 25491868-8 2014 Cells cultured on beta-TCMP substrates prepared with increased Mg(2+) concentrations expressed significantly increased levels of ALP activity and osteogenic genes such as, osteocalcin, collagen-1, and Runx2, in comparison to those cultured on commercially available beta-TCP. beta-tricalcium phosphate 18-27 alkaline phosphatase, placental Homo sapiens 129-132 23894078-8 2014 The ALP expression, calcium deposition, and ERK1/2 phosphorylation of rBMSCs, which was promoted by ions released from beta-CS/beta-TCP composites, were blocked by an AMPK inhibitor, Compound C. These results indicate that bioactive ions extracted from beta-CS/beta-TCP composites could stimulate the osteogenic differentiation of rBMSCs via the AMPK-Erk1/2 pathway. beta-tricalcium phosphate 261-269 alkaline phosphatase, placental Homo sapiens 4-7 22092911-9 2013 Specific ALP activity on Ceracell( ) , Osseolive ( ) and Cerasorb M( ) increased with time and expression of bone-related genes ALP, osteonectin, osteopontin and bone sialoprotein II was demonstrated. beta-tricalcium phosphate 25-33 alkaline phosphatase, placental Homo sapiens 9-12 19726532-4 2010 Alkaline phosphatase (ALP) staining and osteogenic gene expression analysis showed that the CSZn and beta-TCP ceramics had significant effects on the promotion of the osteogenic differentiation of MSCs in both non-contact and contact mode. beta-tricalcium phosphate 101-109 alkaline phosphatase, placental Homo sapiens 0-20 22795852-9 2012 ECM-containing beta-TCP scaffolds significantly increased alkaline phosphatase (ALP) specific activity and up-regulated expression of osteogenesis-related genes such as runx2, alkaline phosphatase, osteopontin and osteocalcin in hMSC, compared to beta-TCP scaffolds alone. beta-tricalcium phosphate 15-23 alkaline phosphatase, placental Homo sapiens 58-78 22795852-9 2012 ECM-containing beta-TCP scaffolds significantly increased alkaline phosphatase (ALP) specific activity and up-regulated expression of osteogenesis-related genes such as runx2, alkaline phosphatase, osteopontin and osteocalcin in hMSC, compared to beta-TCP scaffolds alone. beta-tricalcium phosphate 15-23 alkaline phosphatase, placental Homo sapiens 80-83 22795852-9 2012 ECM-containing beta-TCP scaffolds significantly increased alkaline phosphatase (ALP) specific activity and up-regulated expression of osteogenesis-related genes such as runx2, alkaline phosphatase, osteopontin and osteocalcin in hMSC, compared to beta-TCP scaffolds alone. beta-tricalcium phosphate 15-23 alkaline phosphatase, placental Homo sapiens 176-196 22902820-9 2013 In monoculture, beta-TCP scaffolds promoted ALP activities of both hBMSCs and HUVECs when compared to those grown on tissue culture well plates. beta-tricalcium phosphate 16-24 alkaline phosphatase, placental Homo sapiens 44-47 22454365-7 2012 Accordingly, pure CS and CS/beta-TCP composites stimulated osteoblast-like cells to express BMP-2/TGF-beta gene and proteins, and further regulate the expression of Runx2 gene and protein, and ultimately affect the ALP activity and OCN deposition. beta-tricalcium phosphate 28-36 alkaline phosphatase, placental Homo sapiens 215-218 20486786-5 2010 Compared with rASCs cultured on the culture plate, rASCs cultured on beta-TCP had significantly higher ALP activity/protein, OCN content, and mineral formation. beta-tricalcium phosphate 69-77 alkaline phosphatase, placental Homo sapiens 103-106 19726532-4 2010 Alkaline phosphatase (ALP) staining and osteogenic gene expression analysis showed that the CSZn and beta-TCP ceramics had significant effects on the promotion of the osteogenic differentiation of MSCs in both non-contact and contact mode. beta-tricalcium phosphate 101-109 alkaline phosphatase, placental Homo sapiens 22-25 18571999-8 2008 In vivo, ALP activity of cell-loaded TCP 65% ceramics was higher when compared with both the TCP 25% and TCP 75% specimens (p<0.046), and higher in the TCP 75% than TCP 25% specimens (p=0.008). beta-tricalcium phosphate 37-40 alkaline phosphatase, placental Homo sapiens 9-12 18571999-8 2008 In vivo, ALP activity of cell-loaded TCP 65% ceramics was higher when compared with both the TCP 25% and TCP 75% specimens (p<0.046), and higher in the TCP 75% than TCP 25% specimens (p=0.008). beta-tricalcium phosphate 93-96 alkaline phosphatase, placental Homo sapiens 9-12 18571999-8 2008 In vivo, ALP activity of cell-loaded TCP 65% ceramics was higher when compared with both the TCP 25% and TCP 75% specimens (p<0.046), and higher in the TCP 75% than TCP 25% specimens (p=0.008). beta-tricalcium phosphate 93-96 alkaline phosphatase, placental Homo sapiens 9-12 18571999-8 2008 In vivo, ALP activity of cell-loaded TCP 65% ceramics was higher when compared with both the TCP 25% and TCP 75% specimens (p<0.046), and higher in the TCP 75% than TCP 25% specimens (p=0.008). beta-tricalcium phosphate 93-96 alkaline phosphatase, placental Homo sapiens 9-12 18571999-8 2008 In vivo, ALP activity of cell-loaded TCP 65% ceramics was higher when compared with both the TCP 25% and TCP 75% specimens (p<0.046), and higher in the TCP 75% than TCP 25% specimens (p=0.008). beta-tricalcium phosphate 93-96 alkaline phosphatase, placental Homo sapiens 9-12 17053323-8 2006 Osteogenic preinduction was ineffective for CDHA and reduced ALP activity of beta-TCP composites significantly at explantation. beta-tricalcium phosphate 77-85 alkaline phosphatase, placental Homo sapiens 61-64 16411809-9 2005 The addition of HA or beta-TCP resulted in higher ALP enzymatic activity for fetal bone cells and a stronger production of Gla-osteocalcin for adult bone cells. beta-tricalcium phosphate 22-30 alkaline phosphatase, placental Homo sapiens 50-53 12873076-6 2003 The low ALP activity in beta-TCP medium is however an indication of low osteoblastic activity. beta-tricalcium phosphate 24-32 alkaline phosphatase, placental Homo sapiens 8-11 10811302-9 2000 By day 28, cells grown on PPF/beta-TCP reached a maximal ALP activity of 11 (+/- 1) x 10(-7) micromol/min/cell, while the OC production reached 40 (+/- 1) x 10(-6) ng/cell. beta-tricalcium phosphate 30-38 alkaline phosphatase, placental Homo sapiens 57-60 9368137-8 1997 The ALP titer in the culture media of the beta-TCP and HA were quite high in the first 3 days, then decreased rapidly between the third and seventh days. beta-tricalcium phosphate 42-50 alkaline phosphatase, placental Homo sapiens 4-7 33927241-6 2021 Furthermore, when compared with control beta-TCP, we observed an improvement of WST-1 on all days (p < 0.05) as well as of ALP activity (day 7, p < 0.05), with up-regulation of ALP, osteocalcin, and Osteoprotegerin osteogenic genes in cells cultured with the treated beta-TCP. beta-tricalcium phosphate 40-48 alkaline phosphatase, placental Homo sapiens 123-126 33927241-6 2021 Furthermore, when compared with control beta-TCP, we observed an improvement of WST-1 on all days (p < 0.05) as well as of ALP activity (day 7, p < 0.05), with up-regulation of ALP, osteocalcin, and Osteoprotegerin osteogenic genes in cells cultured with the treated beta-TCP. beta-tricalcium phosphate 40-48 alkaline phosphatase, placental Homo sapiens 177-180 35163639-4 2022 The addition of MgO brought about a modest rise in the number of beta-TCP surface particles, indicating improvements in alkaline phosphatase (ALP) activity on day 21 (p < 0.05) and in the WST-1assay on all days (p < 0.05), with a corresponding increase in the upregulation of ALP and bone sialoprotein. beta-tricalcium phosphate 65-73 alkaline phosphatase, placental Homo sapiens 120-140 35163639-4 2022 The addition of MgO brought about a modest rise in the number of beta-TCP surface particles, indicating improvements in alkaline phosphatase (ALP) activity on day 21 (p < 0.05) and in the WST-1assay on all days (p < 0.05), with a corresponding increase in the upregulation of ALP and bone sialoprotein. beta-tricalcium phosphate 65-73 alkaline phosphatase, placental Homo sapiens 142-145 35163639-4 2022 The addition of MgO brought about a modest rise in the number of beta-TCP surface particles, indicating improvements in alkaline phosphatase (ALP) activity on day 21 (p < 0.05) and in the WST-1assay on all days (p < 0.05), with a corresponding increase in the upregulation of ALP and bone sialoprotein. beta-tricalcium phosphate 65-73 alkaline phosphatase, placental Homo sapiens 276-279