PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21703258-0	2011	Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent manner.	Fentanyl	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-45	
21703258-3	2011	However, the effect of fentanyl on HIF-1 activity is not well documented.	Fentanyl	23-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	35-40	
21703258-4	2011	In this study, we investigated the effect of fentanyl and other opioids on HIF-1 activity in human SH-SY5Y neuroblastoma cells, hepatoma Hep3B cells, lung adenocarcinoma A549 cells and mice.	Fentanyl	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-80	
21703258-7	2011	Furthermore, fentanyl was administered intraperitoneally and HIF-1-dependent gene expression was investigated by qRT-PCR in the brains and kidneys of mice.	Fentanyl	13-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66	
21703258-8	2011	A 10-muM concentration of fentanyl and other opioids, including 1 muM morphine and 4 muM remifentanil, induced HIF-1alpha protein expression and HIF-1 target gene expression in an opioid receptor-dependent manner in SH-SY5Y cells with activity peaking at 24h.	Fentanyl	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-121	
21703258-8	2011	A 10-muM concentration of fentanyl and other opioids, including 1 muM morphine and 4 muM remifentanil, induced HIF-1alpha protein expression and HIF-1 target gene expression in an opioid receptor-dependent manner in SH-SY5Y cells with activity peaking at 24h.	Fentanyl	26-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	111-116	
21703258-10	2011	HIF-1alpha stabilization assays and experiments with cycloheximide revealed that fentanyl increased translation from HIF-1alpha mRNA but did not stabilize the HIF-1alpha protein.	Fentanyl	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10	
21703258-10	2011	HIF-1alpha stabilization assays and experiments with cycloheximide revealed that fentanyl increased translation from HIF-1alpha mRNA but did not stabilize the HIF-1alpha protein.	Fentanyl	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127	
21703258-10	2011	HIF-1alpha stabilization assays and experiments with cycloheximide revealed that fentanyl increased translation from HIF-1alpha mRNA but did not stabilize the HIF-1alpha protein.	Fentanyl	81-89	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127	
21703258-11	2011	Furthermore, fentanyl induced HIF-1 target gene expression in the brains of mice but not in their kidneys in a naloxone-sensitive manner.	Fentanyl	13-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	30-35	
21703258-12	2011	In this report, we describe for the first time that fentanyl, both in vitro and in vivo, induces HIF-1 activation under non-hypoxic conditions, leading to increases in expression of genes associated with adaptation to hypoxia.	Fentanyl	52-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	97-102