PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27838497-0	2017	Activation of the Extracellular Signal-Regulated Kinase in the Amygdale Modulates Fentanyl-Induced Hypersensitivity in Rats.	Fentanyl	82-90	Eph receptor B1	Rattus norvegicus	18-55	
27838497-4	2017	Phospho-ERK in CeLC was first found to be increased significantly in OIH rats induced by repeated subcutaneous injection of fentanyl.	Fentanyl	124-132	Eph receptor B1	Rattus norvegicus	8-11	
27838497-5	2017	Blockade of this fentanyl-induced ERK activation by microinjection of U0126, an ERK inhibitor, into the CeLC reversed the behavioral hypersensitivity in a dose-dependent manner.	Fentanyl	17-25	Eph receptor B1	Rattus norvegicus	34-37	
27838497-5	2017	Blockade of this fentanyl-induced ERK activation by microinjection of U0126, an ERK inhibitor, into the CeLC reversed the behavioral hypersensitivity in a dose-dependent manner.	Fentanyl	17-25	Eph receptor B1	Rattus norvegicus	80-83	
27838497-8	2017	These results showed that fentanyl-induced hypersensitivity may occur partly through the mechanism of ERK activation and followed by the strengthening of synaptic transmission in CeLC neurons.	Fentanyl	26-34	Eph receptor B1	Rattus norvegicus	102-105	
27838497-9	2017	PERSPECTIVE: This study provides evidence that ERK in the laterocapsular division of the CeLC is a key contributor to the development of fentanyl-induced hypersensitivity.	Fentanyl	137-145	Eph receptor B1	Rattus norvegicus	47-50	
22537847-7	2012	MEK-ERK inhibition with SL327 fully prevented fentanyl-induced p25 upregulation.	Fentanyl	46-54	Eph receptor B1	Rattus norvegicus	4-7	
22537847-5	2012	In contrast, fentanyl and SNC-80 stimulated cdk5-mediated p-Thr75 DARPP-32 (+116-166%; PKA inhibition) and p-Thr286 MEK1 (+21-82%; MEK inactivation), and this latter effect resulted in uncoupling of MEK to ERK signals.	Fentanyl	13-21	Eph receptor B1	Rattus norvegicus	206-209	
20457614-3	2010	Fentanyl-induced beta-arrestin2-mediated ERK phosphorylation led to the phosphorylation of Yin Yang 1 (YY1).	Fentanyl	0-8	Eph receptor B1	Rattus norvegicus	41-44