PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33998863-7 2021 Materials and Methods: We used whole-body plethysmography to assess the impact of the CB2 cannabinoid agonist LY2828360 on fentanyl-induced respiratory depression using wild-type (WT) and CB2 knockout (CB2KO) mice. Fentanyl 123-131 cannabinoid receptor 2 (macrophage) Mus musculus 86-89 33998863-8 2021 Results: Fentanyl reduced minute ventilation and respiratory frequency without altering tidal volume in both WT and CB2KO mice. Fentanyl 9-17 cannabinoid receptor 2 (macrophage) Mus musculus 116-119 33998863-20 2021 Our findings suggest that the CB2 cannabinoid agonist LY2828360 may provide CB2-mediated protection against fentanyl-induced respiratory depression, a detrimental and unwanted side effect of opioid use and abuse. Fentanyl 108-116 cannabinoid receptor 2 (macrophage) Mus musculus 30-33 33998863-20 2021 Our findings suggest that the CB2 cannabinoid agonist LY2828360 may provide CB2-mediated protection against fentanyl-induced respiratory depression, a detrimental and unwanted side effect of opioid use and abuse. Fentanyl 108-116 cannabinoid receptor 2 (macrophage) Mus musculus 76-79