PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15664838-3	2005	To identify potent and selective chemical compounds against DPP8, we have synthesized a series of isoquinoline and isoindoline derivatives and have tested their inhibitory activity against DPP8, DPP-IV and DPP-II.	isoquinoline	98-110	dipeptidyl peptidase 8	Homo sapiens	60-64	
15927466-2	2005	Analogues that incorporated a bulky substituent at the first carbon position of benzylamine or isoquinoline showed over 30-fold selectivity for DPP-IV over both DPP8 and DPP-II.	isoquinoline	95-107	dipeptidyl peptidase 8	Homo sapiens	161-165	
15664838-4	2005	Isoindoline derivatives were found to be more potent DPP8 inhibitors than isoquinoline derivatives.	isoquinoline	74-86	dipeptidyl peptidase 8	Homo sapiens	53-57	
15664838-6	2005	From SAR results, we speculate that the S1 site of DPP8 may be larger than that of DPP-IV, which would allow the accommodation of larger C-terminal residues, such as isoquinoline or isoindoline.	isoquinoline	166-178	dipeptidyl peptidase 8	Homo sapiens	51-55