PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31534655-4 2019 Optimization of hit 3 by SAR studies guided by SBDD identified indazole 38 (IC50 0.032 muM) and isoquinoline 45 (IC50 0.085 muM) as potent inhibitors of NOTUM. isoquinoline 96-108 latexin Homo sapiens 124-127 25934226-3 2015 Interestingly, the meta analog of triazole-benzene-sulfonamide (34) bearing 6,7-dimethoxy substituents on the isoquinoline ring displayed the most potent aromatase inhibitory activity (IC50=0.2muM) without affecting normal cell. isoquinoline 110-122 latexin Homo sapiens 193-196