PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11522680-5 2001 The glycosaminoglycans (GAGs) of the secreted PGs from insulin-treated HepG2 cells were enriched in chondroitin sulfate (CS) PGs. Glycosaminoglycans 4-22 insulin Homo sapiens 55-62 8731217-7 1996 Adding fibroblast growth factor and insulin tripled the rate of cell turnover and doubled the glycosaminoglycan content of seeded implants, but had no effect on their material properties. Glycosaminoglycans 94-111 insulin Homo sapiens 36-43 1613437-6 1992 More detailed analysis of extracellular-matrix component synthesis showed that basic FGF, IGF-I and insulin each caused significant increases in the synthesis of collagen and sulphated glycosaminoglycans. Glycosaminoglycans 185-203 insulin Homo sapiens 100-107 6094162-3 1984 The maximal responses of somatomedin and insulin in GAG synthesis were the same, but the stimulation of GAG synthesis by maximally effective concentrations of insulin plus somatomedin was not cumulative. Glycosaminoglycans 104-107 insulin Homo sapiens 159-166 7046349-0 1981 Glycosaminoglycan synthesis by human diabetic, normal adult, and embryonic fibroblasts in relation to insulin levels. Glycosaminoglycans 0-17 insulin Homo sapiens 102-109 6094162-2 1984 We confirmed that somatomedin and insulin stimulate GAG synthesis in normal rat chondrocytes. Glycosaminoglycans 52-55 insulin Homo sapiens 34-41 6094162-3 1984 The maximal responses of somatomedin and insulin in GAG synthesis were the same, but the stimulation of GAG synthesis by maximally effective concentrations of insulin plus somatomedin was not cumulative. Glycosaminoglycans 52-55 insulin Homo sapiens 41-48 24654599-0 2014 The ability of insulin to inhibit the formation of amyloid by pro-islet amyloid polypeptide processing intermediates is significantly reduced in the presence of sulfated glycosaminoglycans. Glycosaminoglycans 170-188 insulin Homo sapiens 15-22 153251-3 1979 Cultured skin fibroblasts from both insulin-dependent and noninsulin-dependent diabetics were found to have increased proportions of heparan sulfate in the media relative to the other sulfated glycosaminoglycans. Glycosaminoglycans 193-211 insulin Homo sapiens 36-43 24654599-4 2014 Here we show that insulin is a much less effective amyloid inhibitor of both IAPP and proIAPP processing intermediates in vitro in the presence of model glycosaminoglycans, but does inhibit the formation of amyloid by proIAPP processing intermediates in a homogeneous solution. Glycosaminoglycans 153-171 insulin Homo sapiens 18-25 22107247-4 2012 BMP-2 in the atelocollagen with the supplement of insulin and T3 in the medium could not only produce a greater GAG matrix in a shorter period but also sustain cell viability with lower mortality. Glycosaminoglycans 112-115 insulin Homo sapiens 50-57 23994438-15 2013 Insulin increased scleral GAG synthesis in both RCS and CS eye-cups, having a greater effect in the CS eye-cups. Glycosaminoglycans 26-29 insulin Homo sapiens 0-7 23994438-20 2013 In vitro, as in vivo, insulin prevents choroidal thickening and increases scleral GAG synthesis. Glycosaminoglycans 82-85 insulin Homo sapiens 22-29 23994438-22 2013 Insulin might also cause the choroid to produce secondary signals that affect scleral GAG synthesis. Glycosaminoglycans 86-89 insulin Homo sapiens 0-7 19118259-5 2009 Glycosaminoglycan production in the constructs approached that of native values under the influence of hypoxia and under the influence of insulin. Glycosaminoglycans 0-17 insulin Homo sapiens 138-145 21391299-7 2011 We actually transplanted the poly-L-lactide porous scaffolds carrying the chondrocytes and the atelocollagen mixed with or without insulin, into the nude mice, showing that glycosaminoglycan accumulation was evident in the group with insulin although less without insulin. Glycosaminoglycans 173-190 insulin Homo sapiens 131-138 21391299-7 2011 We actually transplanted the poly-L-lactide porous scaffolds carrying the chondrocytes and the atelocollagen mixed with or without insulin, into the nude mice, showing that glycosaminoglycan accumulation was evident in the group with insulin although less without insulin. Glycosaminoglycans 173-190 insulin Homo sapiens 234-241 21391299-7 2011 We actually transplanted the poly-L-lactide porous scaffolds carrying the chondrocytes and the atelocollagen mixed with or without insulin, into the nude mice, showing that glycosaminoglycan accumulation was evident in the group with insulin although less without insulin. Glycosaminoglycans 173-190 insulin Homo sapiens 234-241 20506225-6 2010 Relative to cultures without added growth factors, treatment of the stem cells with TGF-beta1 and insulin resulted in a 59% increase in GAG synthesis, but there was no significant change in collagen production even though collagen type II gene expression was upregulated 530-fold. Glycosaminoglycans 136-139 insulin Homo sapiens 98-105 18509682-3 2008 Proteoglycans (PG) consisting of low and high sulfated glycosaminoglycans (GAG) are the main components of articular cartilage matrix, and their synthesis is increased by insulin in growth plate cartilage. Glycosaminoglycans 55-73 insulin Homo sapiens 171-178 18509682-3 2008 Proteoglycans (PG) consisting of low and high sulfated glycosaminoglycans (GAG) are the main components of articular cartilage matrix, and their synthesis is increased by insulin in growth plate cartilage. Glycosaminoglycans 75-78 insulin Homo sapiens 171-178 16569486-6 2006 Insulin released from the matrices increased the wet weights of the cartilaginous cell-polymer constructs (up to 3.2-fold), the amount of GAG and collagen in the constructs (up to 2.4-fold and 3.2-fold, respectively) and the GAG and collagen content per cell (1.8-fold and 2.5-fold, respectively), compared to the control. Glycosaminoglycans 138-141 insulin Homo sapiens 0-7 16569486-6 2006 Insulin released from the matrices increased the wet weights of the cartilaginous cell-polymer constructs (up to 3.2-fold), the amount of GAG and collagen in the constructs (up to 2.4-fold and 3.2-fold, respectively) and the GAG and collagen content per cell (1.8-fold and 2.5-fold, respectively), compared to the control. Glycosaminoglycans 225-228 insulin Homo sapiens 0-7