PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28676202-0 2017 Hexacosanol reduces plasma and hepatic cholesterol by activation of AMP-activated protein kinase and suppression of sterol regulatory element-binding protein-2 in HepG2 and C57BL/6J mice. 1-hexacosanol 0-11 sterol regulatory element binding factor 2 Mus musculus 116-159 28676202-7 2017 Alternatively, hexacosanol suppressed the nuclear translocation and activation of sterol regulatory element-binding protein-2 (SREBP-2), a key transcription factor in cholesterol biosynthesis. 1-hexacosanol 15-26 sterol regulatory element binding factor 2 Mus musculus 82-125 28676202-7 2017 Alternatively, hexacosanol suppressed the nuclear translocation and activation of sterol regulatory element-binding protein-2 (SREBP-2), a key transcription factor in cholesterol biosynthesis. 1-hexacosanol 15-26 sterol regulatory element binding factor 2 Mus musculus 127-134 28676202-8 2017 These results collectively suggest that hexacosanol is a major hypocholesterolemic compound in barley sprouts with regulation of AMPK activation and SREBP-2 suppression. 1-hexacosanol 40-51 sterol regulatory element binding factor 2 Mus musculus 149-156 28676202-10 2017 In conclusion, hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. 1-hexacosanol 15-26 sterol regulatory element binding factor 2 Mus musculus 77-83