PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12802279-4 2003 We were interested in examining the effect of 2-AP on p53 phosphorylation and its possible consequences on checkpoint control in cells subjected to various forms of DNA damage. 2-Aminopurine 46-50 tumor protein p53 Homo sapiens 54-57 12802279-5 2003 Here, we show that 2-AP suppresses p53 phosphorylation in response to gamma radiation, adriamycin, or ultraviolet treatment. 2-Aminopurine 19-23 tumor protein p53 Homo sapiens 35-38 12802279-7 2003 However, 2-AP is also capable of inhibiting p53 phosphorylation in cells deficient in ATM, DNA-PK, or ATR suggesting the existence of multiple pathways by which this kinase inhibitor modulates p53 activation. 2-Aminopurine 9-13 tumor protein p53 Homo sapiens 44-47 12802279-7 2003 However, 2-AP is also capable of inhibiting p53 phosphorylation in cells deficient in ATM, DNA-PK, or ATR suggesting the existence of multiple pathways by which this kinase inhibitor modulates p53 activation. 2-Aminopurine 9-13 tumor protein p53 Homo sapiens 193-196 12802279-8 2003 Biologically, the 2-AP-mediated inhibition of p53 stabilization enables wild-type p53-containing cells to bypass adriamycin-induced G(2)/M arrest. 2-Aminopurine 18-22 tumor protein p53 Homo sapiens 46-49 12802279-8 2003 Biologically, the 2-AP-mediated inhibition of p53 stabilization enables wild-type p53-containing cells to bypass adriamycin-induced G(2)/M arrest. 2-Aminopurine 18-22 tumor protein p53 Homo sapiens 82-85