PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18418051-4 2008 Using reporter assays and Electrophoretic Mobility Shift Assays (EMSA), our findings suggest that TAp73-mediated activation of the p21(cip/waf), 14-3-3sigma and Bax gene promoters is abrogated by expressed PLK1 for which post-translational modification of TAp73 Thr-27 appears to be a key step in MCF7 cells. Threonine 262-265 H3 histone pseudogene 16 Homo sapiens 131-134 31394639-2 2006 Phosphorylation at Thr-145 and/or Ser-146 was reported to target p21 to the cytoplasm. Threonine 19-22 H3 histone pseudogene 16 Homo sapiens 65-68 10559936-2 1999 Here we show that p21-activated kinase (Pak1) phosphorylates LIM-kinase at threonine residue 508 within LIM-kinase"s activation loop, and increases LIM-kinase-mediated phosphorylation of the actin-regulatory protein cofilin tenfold in vitro. Threonine 75-84 H3 histone pseudogene 16 Homo sapiens 18-21 11751903-6 2002 The ability of p21(Cip1) to inhibit cyclin D1 nuclear export correlates with its ability to bind to Thr-286-phosphorylated cyclin D1 and thereby prevents cyclin D1.CRM1 association. Threonine 100-103 H3 histone pseudogene 16 Homo sapiens 15-18 12417722-8 2002 Inhibition of Cdk2 activity was associated with increased binding of p21 and p27 to Cdk2 and decreased phosphorylation of Cdk2 on Thr(160). Threonine 130-133 H3 histone pseudogene 16 Homo sapiens 69-72 11707453-6 2002 Analysis of p53-dependent transcription following UV revealed that the phosphorylation of threonine 18 is required for transactivation of the p21, Hdm2 (the human ortholog of Mdm2), and GADD45 genes. Threonine 90-99 H3 histone pseudogene 16 Homo sapiens 142-145 8810926-2 1996 X-ray crystallographic studies of p21 suggest that coordination between threonine-35 and the divalent metal ion plays an important role in these conformational changes. Threonine 72-81 H3 histone pseudogene 16 Homo sapiens 34-37 8810926-7 1996 This result rules out indirect coordination of threonine-35 in the solution structure of p21.Mn(II).GMPPNP, and implicates direct, weak coordination of this residue as suggested by Halkides et al. Threonine 47-56 H3 histone pseudogene 16 Homo sapiens 89-92 8810927-0 1996 High frequency (139.5 GHz) electron paramagnetic resonance spectroscopy of the GTP form of p21 ras with selective 17O labeling of threonine. Threonine 130-139 H3 histone pseudogene 16 Homo sapiens 91-94 8810926-3 1996 Recent ESEEM studies of p21 in solution, however, place threonine-35 more distant from the metal and were interpreted as weak or indirect coordination of this residue. Threonine 56-65 H3 histone pseudogene 16 Homo sapiens 24-27 8810926-4 1996 We report high frequency (139.5 GHz) EPR spectroscopy of p21.Mn(II) complexes of two guanine nucleotides that probes the link between threonine-35 and the divalent metal ion. Threonine 134-143 H3 histone pseudogene 16 Homo sapiens 57-60 29695509-3 2018 In addition to the well-described tandem phosphorylation of Thr-52 and Ser-62 in the Myc transactivation domain linked to its degradation, P21 (RAC1)-activated kinase 2 (PAK2)-mediated phosphorylation of serine and threonine residues in the C-terminal basic helix-loop-helix leucine zipper (bHLH-LZ) region regulates Myc transcriptional activity. Threonine 215-224 H3 histone pseudogene 16 Homo sapiens 139-142 34069970-5 2021 We also found that delta-catenin could regulate the interaction between AKT and p21, leading to phosphorylation of p21 at Thr-145 residue. Threonine 122-125 H3 histone pseudogene 16 Homo sapiens 80-83 34069970-5 2021 We also found that delta-catenin could regulate the interaction between AKT and p21, leading to phosphorylation of p21 at Thr-145 residue. Threonine 122-125 H3 histone pseudogene 16 Homo sapiens 115-118 3919305-3 1985 Recently, we and others have observed that normal p21, encoded by the Ha-ras gene, has a GTP hydrolytic activity that is reduced by the oncogenic substitutions Val 12 or Thr 59. Threonine 170-173 H3 histone pseudogene 16 Homo sapiens 50-53 6148703-5 1984 However, mutations at position 12 in recombinant (Thr 59) p21 molecules were observed to affect autophosphorylation. Threonine 50-53 H3 histone pseudogene 16 Homo sapiens 58-61 6311615-1 1983 The transforming proteins (p21) of Harvey and Kirsten sarcoma viruses threonine kinase activity, which phosphorylates threonine 59 of the p21 proteins themselves. Threonine 70-79 H3 histone pseudogene 16 Homo sapiens 27-30 6311615-1 1983 The transforming proteins (p21) of Harvey and Kirsten sarcoma viruses threonine kinase activity, which phosphorylates threonine 59 of the p21 proteins themselves. Threonine 70-79 H3 histone pseudogene 16 Homo sapiens 138-141 6311615-2 1983 A tridecapeptide: Arg-Arg-Leu56-Asp-Thr-Thr59-Gly-Gln-Glu-Tyr-Ser-Ala66 containing residues 56-66 of p21 is phosphorylated solely on tyrosine by the epidermal growth factor (EGF)-stimulated tyrosine kinase of A431 cell membranes. Threonine 36-39 H3 histone pseudogene 16 Homo sapiens 101-104 29695509-3 2018 In addition to the well-described tandem phosphorylation of Thr-52 and Ser-62 in the Myc transactivation domain linked to its degradation, P21 (RAC1)-activated kinase 2 (PAK2)-mediated phosphorylation of serine and threonine residues in the C-terminal basic helix-loop-helix leucine zipper (bHLH-LZ) region regulates Myc transcriptional activity. Threonine 60-63 H3 histone pseudogene 16 Homo sapiens 139-142 8142406-15 1994 A sample of p21 in which the Thr residues were fully labeled with 13C and 15N yielded a value of 5.0 A for the distance from MnII to the amide nitrogen of Thr35, while the 13C signal is much smaller than expected if Thr35 were coordinated. Threonine 29-32 H3 histone pseudogene 16 Homo sapiens 12-15 1569940-2 1992 Mutations of residues in loop L1 (Gly-12 and Gly-13), in loop L2 (Thr-35 and Asp-38), and in loop L4 (Gln-61 and Glu-63) influence the reaction in different ways, but all of these mutant p21 proteins still form complexes with GAP. Threonine 66-69 H3 histone pseudogene 16 Homo sapiens 187-190 3540608-6 1986 Mutants with the Thr-59 substitution exhibited a three- to ninefold-higher rate of GDP and GTP release than normal p21 or mutants with other activating lesions. Threonine 17-20 H3 histone pseudogene 16 Homo sapiens 115-118 30683654-3 2019 Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest. Threonine 65-68 H3 histone pseudogene 16 Homo sapiens 169-172 30683654-3 2019 Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest. Threonine 65-68 H3 histone pseudogene 16 Homo sapiens 305-308 21311948-5 2011 Furthermore, SP600125 induces the phosphorylation of p21 at Thr 145 through the PI3K/Akt pathway. Threonine 60-63 H3 histone pseudogene 16 Homo sapiens 53-56 26333122-6 2015 The p53 protein was activated and phosphorylated at serines 15 and 392 and accumulated in the nucleus after 24 and 48 h. The Mdm2 protein was present in the cytoplasm with its maximal level after 8 and 16 h. The p21 protein was detected in the nucleus after 24 and 48 h. Increased levels of phosphorylated Chk2 at threonine 68 were observed in the cytoplasmic fraction after 24 and 48 h of mitoxantrone treatment. Threonine 314-323 H3 histone pseudogene 16 Homo sapiens 212-215 22315229-2 2012 Earlier studies suggest that upon DNA damage, a specific B subunit, B56gamma, bridges the PP2A AC core to p53, leading to dephosphorylation of p53 at Thr-55, induction of the p53 transcriptional target p21, and the inhibition of cell proliferation and transformation. Threonine 150-153 H3 histone pseudogene 16 Homo sapiens 202-205