PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20877636-0 2010 Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain. Threonine 18-27 Cbl proto-oncogene Homo sapiens 133-138 20877636-8 2010 This obvious reduction in binding affinity, however, indicates that Cbl"s interactions with its TKB-centered binding partners may be more favorable in the absence of Ser/Thr phosphorylation, which is stimulation and context specific in vivo. Threonine 170-173 Cbl proto-oncogene Homo sapiens 68-71 17255109-10 2007 c-Cbl binding likely targets Spry2 for ubiquitin-linked destruction, whereas the phosphatase binding and activity are necessary to dephosphorylate specific Ser/Thr residues. Threonine 160-163 Cbl proto-oncogene Homo sapiens 0-5 18662810-5 2008 CBL showed maximum affinity for human tumor-associated Tn-antigens (GalNAcalpha1-Ser/Thr) at the molecular level and was 3.5 times higher than GalNAc. Threonine 85-88 Cbl proto-oncogene Homo sapiens 0-3 10623852-5 2000 Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues. Threonine 221-230 Cbl proto-oncogene Homo sapiens 28-31 10623852-5 2000 Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues. Threonine 221-230 Cbl proto-oncogene Homo sapiens 167-170