PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28809765-0 2017 Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372. Threonine 108-117 cyclin dependent kinase 5 Homo sapiens 0-25 26823173-3 2016 We here show that phosphorylation of coronin 1 on Thr(418/424) by cyclin-dependent kinase (CDK) 5 activity was responsible for coronin 1-Galphas association and the modulation of cAMP production. Threonine 50-53 cyclin dependent kinase 5 Homo sapiens 66-97 27735944-4 2016 Whole-genome microarray analysis, co-immunoprecipitation, in vitro kinase assay, western blotting, luciferase reporter assays and electrophoretic mobility shift assay (EMSA) showed that CDK5 could directly phosphorylate ERK5 at threonine (Thr) 732 and finally modulate the oncogenic ERK5-AP-1 axis. Threonine 228-237 cyclin dependent kinase 5 Homo sapiens 186-190 27735944-4 2016 Whole-genome microarray analysis, co-immunoprecipitation, in vitro kinase assay, western blotting, luciferase reporter assays and electrophoretic mobility shift assay (EMSA) showed that CDK5 could directly phosphorylate ERK5 at threonine (Thr) 732 and finally modulate the oncogenic ERK5-AP-1 axis. Threonine 239-242 cyclin dependent kinase 5 Homo sapiens 186-190 25355946-6 2015 Additional data indicate that, in neurons, CDK5 is the kinase responsible for phosphorylating kinesin-5 at Thr-926, which is important for kinesin-5 to associate with microtubules. Threonine 107-110 cyclin dependent kinase 5 Homo sapiens 43-47 25909891-7 2015 Active p35/Cdk5 complex in the cytosol phosphorylates Nrf2 at Thr(395), Ser(433) and Thr(439) that is sufficient to promote Nrf2 translocation to the nucleus and induce the expression of antioxidant genes. Threonine 62-65 cyclin dependent kinase 5 Homo sapiens 11-15 25909891-7 2015 Active p35/Cdk5 complex in the cytosol phosphorylates Nrf2 at Thr(395), Ser(433) and Thr(439) that is sufficient to promote Nrf2 translocation to the nucleus and induce the expression of antioxidant genes. Threonine 85-88 cyclin dependent kinase 5 Homo sapiens 11-15 25760044-4 2015 Among them, Tat has been shown to hyper-activate cyclin-dependent kinase [CDK] 5, a member of the Ser/Thr CDKs involved in cell migration, angiogenesis, neurogenesis and synaptic plasticity. Threonine 102-105 cyclin dependent kinase 5 Homo sapiens 74-77 25760044-4 2015 Among them, Tat has been shown to hyper-activate cyclin-dependent kinase [CDK] 5, a member of the Ser/Thr CDKs involved in cell migration, angiogenesis, neurogenesis and synaptic plasticity. Threonine 102-105 cyclin dependent kinase 5 Homo sapiens 106-110 21209322-0 2011 High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. Threonine 122-131 cyclin dependent kinase 5 Homo sapiens 32-36 23362255-5 2013 Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5. Threonine 58-61 cyclin dependent kinase 5 Homo sapiens 128-132 25076872-4 2014 Tau is phosphorylated at many sites via several protein kinases, and a characteristic is phosphorylation at Ser/Thr residues in Ser/Thr-Pro sequences, which are targeted by proline-directed protein kinases such as ERK, GSK3beta, and Cdk5. Threonine 112-115 cyclin dependent kinase 5 Homo sapiens 233-237 25076872-4 2014 Tau is phosphorylated at many sites via several protein kinases, and a characteristic is phosphorylation at Ser/Thr residues in Ser/Thr-Pro sequences, which are targeted by proline-directed protein kinases such as ERK, GSK3beta, and Cdk5. Threonine 132-135 cyclin dependent kinase 5 Homo sapiens 233-237 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 33-36 cyclin dependent kinase 5 Homo sapiens 0-4 24235147-6 2013 Cdk5 phosphorylates CLOCK at the Thr-451 and Thr-461 residues in association with transcriptional activation of CLOCK. Threonine 45-48 cyclin dependent kinase 5 Homo sapiens 0-4 22820052-7 2012 Increased total protein levels of cdk-5, p35 and p25 resulted in increased cdk-5 kinase activity as determined by increased phosphorylation of dopamine and adenosine regulated phosphoprotein-32 (DARPP32) at Thr(75) in the NA. Threonine 207-210 cyclin dependent kinase 5 Homo sapiens 34-39 22820052-7 2012 Increased total protein levels of cdk-5, p35 and p25 resulted in increased cdk-5 kinase activity as determined by increased phosphorylation of dopamine and adenosine regulated phosphoprotein-32 (DARPP32) at Thr(75) in the NA. Threonine 207-210 cyclin dependent kinase 5 Homo sapiens 75-80 22820052-8 2012 DARPP32 Thr(75) is selectively phosphorylated by cdk-5 and phosphorylation of DARPP32 at Thr(75) suppresses DARPP32 activity, a critical step in the regulation of both glutamatergic and dopaminergic activity in neurons. Threonine 8-11 cyclin dependent kinase 5 Homo sapiens 49-54 22820052-8 2012 DARPP32 Thr(75) is selectively phosphorylated by cdk-5 and phosphorylation of DARPP32 at Thr(75) suppresses DARPP32 activity, a critical step in the regulation of both glutamatergic and dopaminergic activity in neurons. Threonine 89-92 cyclin dependent kinase 5 Homo sapiens 49-54 20717630-4 2010 In the physiological condition, Cdk5 plays a key role in the CNS development by phosphorylating the specific serine or threonine site of numerous substrate proteins that are closely associated with the neuronal migration, synaptogenesis, synaptic transmission as well as synaptic plasticity. Threonine 119-128 cyclin dependent kinase 5 Homo sapiens 32-36 21144757-5 2011 Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs. Threonine 146-155 cyclin dependent kinase 5 Homo sapiens 0-25 21144757-5 2011 Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs. Threonine 146-155 cyclin dependent kinase 5 Homo sapiens 27-31 21056617-10 2011 The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta. Threonine 77-80 cyclin dependent kinase 5 Homo sapiens 141-145 17693641-5 2007 The phosphorylation sites Thr(14), Ser(18), Ser(160) for Cdk5; Ser(18), Ser(160) for ERK2, and Ser(32) for PKA were identified by mass spectrometry. Threonine 26-29 cyclin dependent kinase 5 Homo sapiens 57-61 20457142-5 2010 In addition to tau hyperphosphorylation, inhibition of serine/threonine phosphorylation induced upregulation of cdk5 levels, which was attenuated by E2 in a manner that was counteracted by ICI 182,780. Threonine 62-71 cyclin dependent kinase 5 Homo sapiens 112-116 20473298-4 2010 Cdk5 complexes phosphorylate Ape1 at Thr 232 and thereby reduces its apurinic/apyrimidinic (AP) endonuclease activity. Threonine 37-40 cyclin dependent kinase 5 Homo sapiens 0-4 19136008-7 2009 In search of the kinase responsible for the phosphorylation at this site, we found that threonine 10 of H1.5 can be phosphorylated by glycogen synthase kinase-3 in vitro, but not by cyclin-dependent kinase 1/cyclin B and cyclin-dependent kinase 5/p35, respectively. Threonine 88-97 cyclin dependent kinase 5 Homo sapiens 221-246 18818692-5 2008 Moreover, we found that the Ser-40, Thr-121 and Ser-163 triple phosphorylation of Cdh1 by the cyclin-dependent kinase-5 (Cdk5)-p25 complex was necessary and sufficient for cyclin B1 stabilization and apoptotic death after NMDAR stimulation. Threonine 36-39 cyclin dependent kinase 5 Homo sapiens 94-119 18818692-5 2008 Moreover, we found that the Ser-40, Thr-121 and Ser-163 triple phosphorylation of Cdh1 by the cyclin-dependent kinase-5 (Cdk5)-p25 complex was necessary and sufficient for cyclin B1 stabilization and apoptotic death after NMDAR stimulation. Threonine 36-39 cyclin dependent kinase 5 Homo sapiens 121-125 18948252-2 2008 In turn, activated CDK5 phosphorylates the Rho family GTP-binding protein TC10alpha on threonine 197 that is sensitive to the CDK5 inhibitor olomoucine and blocked by small interfering RNA-mediated knockdown of CDK5. Threonine 87-96 cyclin dependent kinase 5 Homo sapiens 19-23 18948252-2 2008 In turn, activated CDK5 phosphorylates the Rho family GTP-binding protein TC10alpha on threonine 197 that is sensitive to the CDK5 inhibitor olomoucine and blocked by small interfering RNA-mediated knockdown of CDK5. Threonine 87-96 cyclin dependent kinase 5 Homo sapiens 126-130 18948252-2 2008 In turn, activated CDK5 phosphorylates the Rho family GTP-binding protein TC10alpha on threonine 197 that is sensitive to the CDK5 inhibitor olomoucine and blocked by small interfering RNA-mediated knockdown of CDK5. Threonine 87-96 cyclin dependent kinase 5 Homo sapiens 126-130 16407256-4 2006 An energy decomposition analysis, used for these purposes, revealed why the binding of p25 alone is sufficient to stabilize the extended active T-loop conformation of CDK5, whereas the equivalent conformational change in CDK2 requires both the binding of cyclin A and phosphorylation of the Thr(160) residue. Threonine 291-294 cyclin dependent kinase 5 Homo sapiens 167-171 17121546-6 2006 We found that Cdk5 could phosphorylate SCLIP and CRMP-1 in vitro and the two proteins in cultured cells showed a mobility shift depending on Cdk5 activity and the presence of specific Ser or Thr residues, indicating that SCLIP and CRMP-1 are likely substrates for Cdk5 in vitro and in cultured cells. Threonine 191-194 cyclin dependent kinase 5 Homo sapiens 14-18 17220300-9 2007 Inhibition of the Cdk5 activity or suppression of Cdk5 expression blocked S6K1 phosphorylation at Ser-411 and Thr-389, resulting in S6K1 inactivation. Threonine 110-113 cyclin dependent kinase 5 Homo sapiens 18-22 17220300-9 2007 Inhibition of the Cdk5 activity or suppression of Cdk5 expression blocked S6K1 phosphorylation at Ser-411 and Thr-389, resulting in S6K1 inactivation. Threonine 110-113 cyclin dependent kinase 5 Homo sapiens 50-54 17301223-1 2007 Our previous studies of DARPP-32 in striatal slices have shown that activation of D1 receptors leads to cAMP-dependent dephosphorylation of Thr-75, the Cdk5 site in DARPP-32. Threonine 140-143 cyclin dependent kinase 5 Homo sapiens 152-156 15483118-6 2004 Cdk5 phosphorylates CRMP-2 at serine 522, possibly facilitating phosphorylation of serine 518 and threonine 514 by glycogen synthase kinase 3beta (GSK3beta), a kinase previously implicated in Sema 3A signaling. Threonine 98-107 cyclin dependent kinase 5 Homo sapiens 0-4 12832492-3 2003 Two cdk5-specific phosphorylation sites on nestin, Thr-1495 and Thr-316, were established, the latter of which was used as a marker for cdk5-specific phosphorylation in vivo. Threonine 51-54 cyclin dependent kinase 5 Homo sapiens 4-8 12832492-3 2003 Two cdk5-specific phosphorylation sites on nestin, Thr-1495 and Thr-316, were established, the latter of which was used as a marker for cdk5-specific phosphorylation in vivo. Threonine 64-67 cyclin dependent kinase 5 Homo sapiens 4-8 12832492-6 2003 In the myoblasts, a disassembly-linked phosphorylation of Thr-316 indicated active phosphorylation of nestin by cdk5. Threonine 58-61 cyclin dependent kinase 5 Homo sapiens 112-116 12832492-8 2003 Inhibition of cdk5 activity-either by transfection with dominant-negative cdk5 or by using a specific cdk5 inhibitor-blocked myoblast differentiation and phosphorylation of nestin at Thr-316, and this inhibition markedly disturbed the organization of nestin. Threonine 183-186 cyclin dependent kinase 5 Homo sapiens 14-18 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 46-49 cyclin dependent kinase 5 Homo sapiens 14-18 12226093-7 2002 Phosphopeptide mapping revealed enhanced phosphorylation of Ser(202)/Thr(205) residues by p25-CDK5 (amino acid residues of tau are numbered according to the longest isoform of human tau). Threonine 69-72 cyclin dependent kinase 5 Homo sapiens 94-98 12226093-8 2002 These results suggest that cleavage of p35 to p25 greatly enhances the kinase activity of CDK5 and increases the phosphorylation of Ser(202)/Thr(205). Threonine 141-144 cyclin dependent kinase 5 Homo sapiens 90-94 12226093-9 2002 Considering the fact that phosphorylation of Ser(202)/Thr(205) antagonizes the tau-mediated nucleation of tubulin, p25-CDK5 may play a pivotal role in neuronal cell death in Alzheimer"s disease. Threonine 54-57 cyclin dependent kinase 5 Homo sapiens 119-123 12387894-7 2002 Deglycosylation by glycosidases depressed the subsequent phosphorylation of AD-tau (i) with cdk5 at Thr-181, Ser-199, Ser-202, Thr-205, and Ser-404, but not at Thr-212; and (ii) with GSK-3beta at Thr-181, Ser-202, Thr-205, Ser-217, and Ser-404, but not at Ser-199, Thr-212, Thr-231, or Ser-396. Threonine 100-103 cyclin dependent kinase 5 Homo sapiens 92-96 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 73-76 cyclin dependent kinase 5 Homo sapiens 14-18 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 73-76 cyclin dependent kinase 5 Homo sapiens 14-18 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 73-76 cyclin dependent kinase 5 Homo sapiens 14-18 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 73-76 cyclin dependent kinase 5 Homo sapiens 14-18 12387894-5 2002 We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. Threonine 73-76 cyclin dependent kinase 5 Homo sapiens 14-18 12056836-4 2002 Here we demonstrate that cyclin dependent kinase-5/p35 (cdk5/p35) phosphorylates PS1 on threonine(354) within C-PS1 both in vitro and in vivo. Threonine 88-97 cyclin dependent kinase 5 Homo sapiens 25-54 12071639-2 2002 Recent in vitro studies have shown that cdk5 phosphorylates tau at serine 199, serine 202, and threonine 205 and that p25, an activator of cdk5, is increased in Alzheimer disease (AD). Threonine 95-104 cyclin dependent kinase 5 Homo sapiens 40-44 12056836-4 2002 Here we demonstrate that cyclin dependent kinase-5/p35 (cdk5/p35) phosphorylates PS1 on threonine(354) within C-PS1 both in vitro and in vivo. Threonine 88-97 cyclin dependent kinase 5 Homo sapiens 56-60 11604394-3 2001 We have now demonstrated direct phosphorylation of Pak1 on threonine 212 by the p35/Cdk5 kinase. Threonine 59-68 cyclin dependent kinase 5 Homo sapiens 84-88 11181841-7 2001 Based on these experiments, we conclude that tau protein kinase II (cdk5/p20) can phosphorylate human tau at Thr(181), Thr(205), Thr(212), Thr(217), Ser(396) and Ser(404). Threonine 109-112 cyclin dependent kinase 5 Homo sapiens 68-72 11181841-7 2001 Based on these experiments, we conclude that tau protein kinase II (cdk5/p20) can phosphorylate human tau at Thr(181), Thr(205), Thr(212), Thr(217), Ser(396) and Ser(404). Threonine 119-122 cyclin dependent kinase 5 Homo sapiens 68-72 11181841-7 2001 Based on these experiments, we conclude that tau protein kinase II (cdk5/p20) can phosphorylate human tau at Thr(181), Thr(205), Thr(212), Thr(217), Ser(396) and Ser(404). Threonine 119-122 cyclin dependent kinase 5 Homo sapiens 68-72 11181841-7 2001 Based on these experiments, we conclude that tau protein kinase II (cdk5/p20) can phosphorylate human tau at Thr(181), Thr(205), Thr(212), Thr(217), Ser(396) and Ser(404). Threonine 119-122 cyclin dependent kinase 5 Homo sapiens 68-72 11013232-11 2001 Indirubin-3"-monoxime also inhibits the in vivo phosphorylation of DARPP-32 by CDK5 on Thr-75, thereby mimicking one of the effects of dopamine in the striatum. Threonine 87-90 cyclin dependent kinase 5 Homo sapiens 79-83 10413323-2 1999 Many of the phosphorylation sites on tau are serine/threonine-proline sequences, several of which are phosphorylated in vitro by neuronal Cdc2-like kinase (Nclk), a kinase composed of Cdk5 and its activator(s). Threonine 52-61 cyclin dependent kinase 5 Homo sapiens 184-188 10366442-5 1999 Active or inactive Cdk5 was associated with cyclin D1, but only active Cdk5 exhibited threonine phosphorylation. Threonine 86-95 cyclin dependent kinase 5 Homo sapiens 71-75 11050161-2 2000 In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. Threonine 91-94 cyclin dependent kinase 5 Homo sapiens 31-56 11050161-2 2000 In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. Threonine 91-94 cyclin dependent kinase 5 Homo sapiens 58-62 10936190-3 2000 In vitro, active cyclin-dependent kinase 5 (Cdk5) phosphorylated the cytoplasmic domain of APP at Thr(668). Threonine 98-101 cyclin dependent kinase 5 Homo sapiens 17-42 10936190-3 2000 In vitro, active cyclin-dependent kinase 5 (Cdk5) phosphorylated the cytoplasmic domain of APP at Thr(668). Threonine 98-101 cyclin dependent kinase 5 Homo sapiens 44-48 10092646-2 1999 However, it phosphorylates serines/threonines in S/TPXK/R-type motifs like other CDKs. Threonine 35-45 cyclin dependent kinase 5 Homo sapiens 81-85 10092646-4 1999 CDKs have been shown to have a high preference for a basic residue (lysine or arginine) as the n+3 residue, n being the location in the primary sequence of a phosphoacceptor serine or threonine. Threonine 184-193 cyclin dependent kinase 5 Homo sapiens 0-4 9735171-5 1998 Further, the kinase combinations cdk5/GSK-3 and CaM kinase II/GSK-3 rapidly phosphorylated the sites Thr 231 and Ser 235. Threonine 101-104 cyclin dependent kinase 5 Homo sapiens 33-37 26376215-2 2015 Recently, Cdk5 has been reported to phosphorylate TRPV1 at threonine 407 (Thr-407) in humans (Thr-406 in rats), which enhances the function of TRPV1 channel and promotes thermal hyperalgesia in the complete Freund"s adjuvant (CFA)-induced inflammatory pain rats. Threonine 59-68 cyclin dependent kinase 5 Homo sapiens 10-14 26376215-2 2015 Recently, Cdk5 has been reported to phosphorylate TRPV1 at threonine 407 (Thr-407) in humans (Thr-406 in rats), which enhances the function of TRPV1 channel and promotes thermal hyperalgesia in the complete Freund"s adjuvant (CFA)-induced inflammatory pain rats. Threonine 74-77 cyclin dependent kinase 5 Homo sapiens 10-14 26376215-2 2015 Recently, Cdk5 has been reported to phosphorylate TRPV1 at threonine 407 (Thr-407) in humans (Thr-406 in rats), which enhances the function of TRPV1 channel and promotes thermal hyperalgesia in the complete Freund"s adjuvant (CFA)-induced inflammatory pain rats. Threonine 94-97 cyclin dependent kinase 5 Homo sapiens 10-14