PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28691797-4 2017 To structurally investigate the mechanism of hHint1 catalysis, we have designed and prepared nucleoside thiophosphoramidate substrates that are able to capture the transiently formed nucleotidylated-His112 intermediate (E*) using time-dependent crystallography. nucleoside thiophosphoramidate 93-123 histidine triad nucleotide binding protein 1 Homo sapiens 45-51