PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33754071-5 2021 Methods: Charge-switchable zwitterionic polycarboxybetaine (PCB) was used to load insulin to form PCB/insulin (PCB/INS) particles through the electrostatic interaction between positively charged PCB in pH 5.0 and negatively charged insulin in 0.01 M NaOH. Indium 115-118 insulin Homo sapiens 82-89 33754071-13 2021 In streptozotocin-induced type 1 diabetic rats, oral administration of PCB/INS particles with diameter sub-200 nm, especially in capsules, significantly enhanced the bioavailability of insulin and achieved longer duration of hypoglycemic effect than the subcutaneously injected insulin. Indium 75-78 insulin Homo sapiens 185-192 33754071-13 2021 In streptozotocin-induced type 1 diabetic rats, oral administration of PCB/INS particles with diameter sub-200 nm, especially in capsules, significantly enhanced the bioavailability of insulin and achieved longer duration of hypoglycemic effect than the subcutaneously injected insulin. Indium 75-78 insulin Homo sapiens 278-285 33754071-5 2021 Methods: Charge-switchable zwitterionic polycarboxybetaine (PCB) was used to load insulin to form PCB/insulin (PCB/INS) particles through the electrostatic interaction between positively charged PCB in pH 5.0 and negatively charged insulin in 0.01 M NaOH. Indium 115-118 insulin Homo sapiens 102-109 33754071-5 2021 Methods: Charge-switchable zwitterionic polycarboxybetaine (PCB) was used to load insulin to form PCB/insulin (PCB/INS) particles through the electrostatic interaction between positively charged PCB in pH 5.0 and negatively charged insulin in 0.01 M NaOH. Indium 115-118 insulin Homo sapiens 102-109 33754071-10 2021 PCB/INS particles achieved sustained release of insulin at pH 7.4 due to their charge-switchable ability. Indium 4-7 insulin Homo sapiens 48-55 33754071-11 2021 Surprisingly, PCB/INS particles induced the open of the tight junctions of intestinal epithelium in endocytosis-mediated lysosomal degradation pathway, which resulted in increased intestinal permeability of insulin. Indium 18-21 insulin Homo sapiens 207-214 29859544-1 2018 This review attempts to explain why consuming extra myoinositol (Ins), an essential component of membrane phospholipids, is often beneficial for patients with conditions characterised by insulin resistance, non-alcoholic fatty liver disease and endoplasmic reticulum (ER) stress. Indium 65-68 insulin Homo sapiens 187-194