PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31377845-0	2020	DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools.	2'-deoxycytidine 5'-triphosphate	62-66	dCTP pyrophosphatase 1	Homo sapiens	0-6	
31377845-2	2020	Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5"-modified dCTP derivatives, but its contribution to overall nucleotide metabolism is controversial.	2'-deoxycytidine 5'-triphosphate	16-20	dCTP pyrophosphatase 1	Homo sapiens	40-46	
31377845-2	2020	Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5"-modified dCTP derivatives, but its contribution to overall nucleotide metabolism is controversial.	2'-deoxycytidine 5'-triphosphate	97-101	dCTP pyrophosphatase 1	Homo sapiens	40-46	
31377845-3	2020	Here, we identify a central role for DCTPP1 in the homeostasis of dCTP, dTTP and dUTP.	2'-deoxycytidine 5'-triphosphate	66-70	dCTP pyrophosphatase 1	Homo sapiens	37-43	
26075750-13	2015	Our current investigations point to the pathological functions of DCTPP1 overexpression in breast cancer cells with aberrant dCTP metabolism and epigenetic modification.	2'-deoxycytidine 5'-triphosphate	125-129	dCTP pyrophosphatase 1	Homo sapiens	66-72	
27325794-6	2016	Moreover, DCTPP1 hydrolyses the triphosphate form of decitabine with similar kinetic efficiency to its natural substrate dCTP and prevents decitabine-induced global DNA demethylation.	2'-deoxycytidine 5'-triphosphate	121-125	dCTP pyrophosphatase 1	Homo sapiens	10-16	
24467396-6	2014	Interestingly, we found that in addition to dCTP, methyl-dCTP and 5-halogenated nucleotides, DCTPP1 hydrolyses 5-formyl-dCTP very efficiently and with the lowest Km value described so far.	2'-deoxycytidine 5'-triphosphate	44-48	dCTP pyrophosphatase 1	Homo sapiens	93-99	
24467396-8	2014	DCTPP1-deficient cells accumulate high levels of dCTP and are hypersensitive to exposure to the nucleoside analogues 5-iodo-2"-deoxycytidine and 5-methyl-2"-deoxycytidine.	2'-deoxycytidine 5'-triphosphate	49-53	dCTP pyrophosphatase 1	Homo sapiens	0-6	
24467396-9	2014	The results of the present study indicate that DCTPP1 has a central role in the balance of dCTP and the metabolism of deoxycytidine analogues, thus contributing to the preservation of genome integrity.	2'-deoxycytidine 5'-triphosphate	91-95	dCTP pyrophosphatase 1	Homo sapiens	47-53	
17320107-2	2007	Here, we report the crystal structures of the core fragment of RS21-C6, named RSCUT, and the complex with the substrate 5-methyl dCTP.	2'-deoxycytidine 5'-triphosphate	129-133	dCTP pyrophosphatase 1	Homo sapiens	63-70