PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35583123-0	2022	Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.	methysticin	0-11	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	53-72	
35583123-3	2022	Methysticin exhibited time-, concentration-, and NADPH-dependent inhibition on CYP2C9 using diclofenac as a probe substrate.	methysticin	0-11	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	79-85	
35583123-4	2022	Approximately 85% of CYP2C9 activity was inhibited by methysticin at 50 muM after a 30 min preincubation with human liver microsomes in the presence of NADPH.	methysticin	54-65	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	21-27	
35583123-6	2022	Sulfaphenazole (competitive inhibitor of CYP2C9) displayed a significant protective effect on methysticin-induced CYP2C9 inactivation.	methysticin	94-105	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	41-47	
35583123-6	2022	Sulfaphenazole (competitive inhibitor of CYP2C9) displayed a significant protective effect on methysticin-induced CYP2C9 inactivation.	methysticin	94-105	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	114-120	
35583123-8	2022	A carbene intermediate was postulated to be involved in methysticin-induced CYP2C9 inactivation as K3Fe(CN)6 recovered 14.96% of CYP2C9 activity.	methysticin	56-67	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	76-82	
35583123-8	2022	A carbene intermediate was postulated to be involved in methysticin-induced CYP2C9 inactivation as K3Fe(CN)6 recovered 14.96% of CYP2C9 activity.	methysticin	56-67	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	129-135	
35583123-9	2022	A methysticin-derived ortho-quinone intermediate dependent on NADPH was trapped by GSH, and this intermediate was believed to be involved in CYP2C9 inactivation.	methysticin	2-13	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	141-147	
35583123-11	2022	Taken together, the present work demonstrated that methysticin was a mechanism-based inactivator of CYP2C9.	methysticin	51-62	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	100-106	
35583123-12	2022	Both ortho-quinone and carbene intermediates appeared to be involved in the inactivation of CYP2C9 induced by methysticin.	methysticin	110-121	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	92-98