PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11514617-8 2001 Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres. Proline 30-37 protein tyrosine kinase 2 Homo sapiens 55-58 11514617-8 2001 Expression of the Cas-binding proline-rich region 1 of FAK hindered association of Cas with FAK and impaired the structural stability of sarcomeres. Proline 30-37 protein tyrosine kinase 2 Homo sapiens 92-95 11514617-10 2001 Moreover, expression of the focal adhesion-targeting and/or the Cas-binding proline-rich regions of FAK inhibited ANP promoter activity and suppressed ET-induced ANP and brain natriuretic peptide gene expression. Proline 76-83 protein tyrosine kinase 2 Homo sapiens 100-103 10791986-8 2000 We report that binding of the SH3 domain of p130Cas to proline-rich region 1 of FAK is required to support survival of fibroblasts on fibronectin when serum is withdrawn. Proline 55-62 protein tyrosine kinase 2 Homo sapiens 80-83 10749687-12 2000 With the use of glutathione S-transferase fusion proteins containing Shc-SH2, Grb2-SH2, and Grb2 N-terminal and C-terminal SH3 domains, it was implied that the proline-rich region of Pyk2 (and FAK) binds to the N-terminal SH3 domain of Grb2 and that the phosphotyrosine residue of Shc binds to the SH2 domain of Grb2. Proline 160-167 protein tyrosine kinase 2 Homo sapiens 193-196 10545505-7 1999 Mapping of the proteolytic cleavage fragments of pp125(FAK) predicts a dissociation of the focal adhesion targeting (FAT) sequence and second proline-rich domain from the tyrosine kinase domain and integrin-binding sequence. Proline 142-149 protein tyrosine kinase 2 Homo sapiens 55-58 25410852-2 2015 The binding involved the 106-to-131 domain, corresponding to the dimerization domain of P and the C-terminal domain of FAK containing the proline-rich domains PRR2 and PRR3. Proline 138-145 protein tyrosine kinase 2 Homo sapiens 119-122 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 22-25 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 10413676-5 1999 Expression of various FAK mutants in the FAK- cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK- cell migration to FN whereas direct paxillin binding to FAK was not required. Proline 136-143 protein tyrosine kinase 2 Homo sapiens 41-44 9553131-5 1998 Half of the carboxyl-terminal region of the GH receptor is dispensable for FAK activation, but FAK activation does require the proline-rich box 1 region of the GH receptor, indicative that FAK is downstream of JAK2. Proline 127-134 protein tyrosine kinase 2 Homo sapiens 95-98 9553131-5 1998 Half of the carboxyl-terminal region of the GH receptor is dispensable for FAK activation, but FAK activation does require the proline-rich box 1 region of the GH receptor, indicative that FAK is downstream of JAK2. Proline 127-134 protein tyrosine kinase 2 Homo sapiens 95-98 9038154-1 1997 Requirements for Src kinase activity and FAK proline-rich motifs. Proline 45-52 protein tyrosine kinase 2 Homo sapiens 41-44 9038154-7 1997 FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK. Proline 100-107 protein tyrosine kinase 2 Homo sapiens 0-3 9038154-7 1997 FAK-Cas association was only observed in the context of Cas binding to at least one of two distinct proline-rich sites on FAK. Proline 100-107 protein tyrosine kinase 2 Homo sapiens 122-125 8995252-3 1997 The structure of RAFTK is similar to p125FAK in that it lacks a transmembrane region, does not contain Src homology 2 or 3 domains, and has a proline-rich region in its C terminus. Proline 142-149 protein tyrosine kinase 2 Homo sapiens 37-44 8662921-6 1996 We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK). Proline 154-161 protein tyrosine kinase 2 Homo sapiens 53-56 8662921-6 1996 We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK). Proline 154-161 protein tyrosine kinase 2 Homo sapiens 70-74 8662921-6 1996 We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK). Proline 154-161 protein tyrosine kinase 2 Homo sapiens 216-219 8662921-6 1996 We show that the association of p130(Cas) with pp125(Fak) and pp41/43(FRNK) is direct, and is mediated by the binding of the SH3 domain of p130(Cas) to a proline-rich sequence present in both the C terminus of pp125(FAK) and in pp41/43(FRNK). Proline 154-161 protein tyrosine kinase 2 Homo sapiens 236-240 7499242-6 1995 In addition, like pp125FAK, RAFTK contains a kinase domain flanked by large N-terminal (426 residues) and C-terminal (331 residues) domains, and the C-terminal region contains a predicted proline-rich stretch of residues. Proline 188-195 protein tyrosine kinase 2 Homo sapiens 18-26 7537275-9 1995 In addition, we show that PtdIns 3-kinase is significantly activated by the p125FAK proline-rich sequence binding to the src homology 3 domain of p85 alpha subunit. Proline 84-91 protein tyrosine kinase 2 Homo sapiens 76-83 33837725-11 2021 Furthermore, we show that the C-terminal portion of the Serine-Threonine-Proline-rich (STP) region, adjacent to the GAIN domain, was required for Src-Fak activation. Proline 73-80 protein tyrosine kinase 2 Homo sapiens 150-153 22952866-6 2012 PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility. Proline 173-180 protein tyrosine kinase 2 Homo sapiens 26-29 22952866-6 2012 PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility. Proline 173-180 protein tyrosine kinase 2 Homo sapiens 112-115 22952866-6 2012 PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility. Proline 173-180 protein tyrosine kinase 2 Homo sapiens 112-115 22952866-6 2012 PRINCIPAL FINDINGS: Using FAK-null fibroblasts stably reconstituted with green fluorescent protein (GFP) tagged FAK constructs, we find that FAK activity and FAK C-terminal proline-rich region 2 (PRR2) and PRR3 are required for FA turnover and cell motility. Proline 173-180 protein tyrosine kinase 2 Homo sapiens 112-115 20150423-8 2010 We mapped the preferred calpain cleavage site between the two C-terminal proline-rich regions after Ser-745, resulting in a C-terminal fragment similar in size to the FAK-related non-kinase (FRNK). Proline 73-80 protein tyrosine kinase 2 Homo sapiens 191-195 22078467-6 2011 Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK. Proline 145-152 protein tyrosine kinase 2 Homo sapiens 99-102 22078467-6 2011 Cortactin, an F-actin associated protein and a substrate of Src kinase, was found to interact with FAK through its SH3 domain and the C-terminal proline-rich regions of FAK. Proline 145-152 protein tyrosine kinase 2 Homo sapiens 169-172 18930841-8 2009 Both phosphorylated FAK residue Y397 and FAK proline-rich domain are involved in Fyn binding. Proline 45-52 protein tyrosine kinase 2 Homo sapiens 41-44 19224453-3 2009 Structurally, FAK consists of an amino-terminal regulatory FERM domain, a central catalytic kinase domain, two proline-rich motifs, and a carboxy-terminal focal adhesion targeting domain. Proline 111-118 protein tyrosine kinase 2 Homo sapiens 14-17 18215142-0 2008 The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning. Proline 29-36 protein tyrosine kinase 2 Homo sapiens 117-120 18560762-7 2008 Although the SH3 domain binds weakly and transiently to proline-rich peptides from FAK, the interaction is not very dynamic and the relative position of the spin-label to the protein is well-defined. Proline 56-63 protein tyrosine kinase 2 Homo sapiens 83-86 18215142-4 2008 In the present study, using phage display, sitedirected mutagenesis, pulldown and immunoprecipitation assays we localized the site of FAK binding to a 7-amino-acid region(amino acids 65-71) in the N-terminal proline-rich domain of human p53. Proline 208-215 protein tyrosine kinase 2 Homo sapiens 134-137 12932330-7 2003 Mutation of proline residues (Pro2) in the amino-terminal region of FAK blocks direct binding with Calpain 2 and also prevents formation of the Calpain 2/p42ERK complex in cells. Proline 12-19 protein tyrosine kinase 2 Homo sapiens 68-71 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 167-170 protein tyrosine kinase 2 Homo sapiens 80-83 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 167-170 protein tyrosine kinase 2 Homo sapiens 80-83 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 167-170 protein tyrosine kinase 2 Homo sapiens 80-83 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 179-186 protein tyrosine kinase 2 Homo sapiens 80-83 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 179-186 protein tyrosine kinase 2 Homo sapiens 80-83 17438336-6 2007 Analysis of FAK(-/-) fibroblasts stably reconstituted with wild type or various FAK point mutants showed that FAK catalytic activity, Tyr-397 phosphorylation, and the Pro-712/713 proline-rich region of FAK were required for TNFalpha-stimulated MAPK activation and IL-6 production. Proline 179-186 protein tyrosine kinase 2 Homo sapiens 80-83 12558988-6 2003 The novel interaction with the amphiphysin SH3 domain, involving the COOH-terminal proline-rich region of FAK, was confirmed by coimmunoprecipitation of the two proteins and a closely similar response to stimuli affecting the actin cytoskeleton. Proline 83-90 protein tyrosine kinase 2 Homo sapiens 106-109