PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27303048-2 2016 Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH). Proline 25-32 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 72-93 31504781-3 2019 In this study, the involvement in dark-induced senescence of proline dehydrogenases (ProDHs), which catalyse the first and rate-limiting step of proline oxidation in mitochondria, was investigated using prodh single- and double-mutants with the help of biochemical, proteomic, and metabolomic approaches. Proline 61-68 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 203-208 29949777-6 2018 DFR1 interacts with proline degradation enzymes PDH1/2 and P5CDH and compromises their activities. Proline 20-27 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 48-54 29949777-7 2018 Genetic analysis showed that DFR1 acts upstream of PDH1/2 and P5CDH to positively regulate proline accumulation. Proline 91-98 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 51-57 32574985-1 2020 Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C). Proline 79-86 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 0-21 32574985-1 2020 Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C). Proline 79-86 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 23-28 32574985-1 2020 Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Delta1-pyrroline-5-carboxylate (P5C). Proline 0-3 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 23-28 29949777-8 2018 Our results demonstrate a regulatory mechanism by which, under drought and freezing stresses, DFR1 interacts with PDH1/2 and P5CDH to abrogate their activities to maintain proline homeostasis, thereby conferring drought and freezing tolerance. Proline 172-179 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 114-120 27303048-2 2016 Upon relief from stress, proline is rapidly oxidized in mitochondria by proline dehydrogenase (ProDH) and then by pyrroline-5-carboxylate dehydrogenase (P5CDH). Proline 25-32 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 95-100 27303048-7 2016 ProDH activity was high for genotypes in which ProDH, most likely ProDH1, was strongly induced by proline. Proline 98-105 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 0-5 27303048-7 2016 ProDH activity was high for genotypes in which ProDH, most likely ProDH1, was strongly induced by proline. Proline 98-105 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 47-52 26284090-3 2015 In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate. Proline 26-29 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 95-112 26284090-3 2015 In the catabolic process, Pro is converted back to Glu using a different pathway that involves Pro dehydrogenase (ProDH), P5C dehydrogenase (P5CDH), and P5C as intermediate. Proline 26-29 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 114-119 25628629-8 2014 The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism. Proline 10-17 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 187-210 25628629-8 2014 The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism. Proline 10-17 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 212-218 25628629-8 2014 The lower proline accumulation is correlated with a lower transcript level of Pyrroline-5-carboxylate synthetase 1 (P5CS1) biosynthetic enzyme and higher transcript and protein levels of Proline dehydrogenase 1 (ProDH1), a key-enzyme in proline catabolism. Proline 237-244 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 212-218 25628629-9 2014 We also found that the ProDH1 expression is induced in a pi3k-hemizygous mutant, further demonstrating that PI3K is involved in the regulation of proline catabolism through transcriptional regulation of ProDH1. Proline 146-153 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 23-29 16810321-2 2006 The Arabidopsis thaliana proline dehydrogenase (ProDH) is catalysing the first step in proline degradation. Proline 25-32 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 48-53 24948556-1 2014 As the first and rate-limiting enzyme of proline degradation, PROLINE DEHYDROGENASE1 (PDH1) is tightly regulated during plant stress responses, including induction under hypoosmolarity and repression under water deficit. Proline 41-48 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 62-84 24948556-1 2014 As the first and rate-limiting enzyme of proline degradation, PROLINE DEHYDROGENASE1 (PDH1) is tightly regulated during plant stress responses, including induction under hypoosmolarity and repression under water deficit. Proline 41-48 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 86-90 23171218-4 2012 RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene. Proline 67-74 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 218-239 23171218-4 2012 RESULTS: Gene expression studies revealed that the accumulation of proline was mediated by an increase in the expression of the proline synthesis genes P5CS1 and P5CS2 and a marginal reduction in the expression of the proline dehydrogenase (ProDH) gene. Proline 67-74 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 241-246 21757996-1 2011 Proline dehydrogenase (ProDH) catalyzes the flavin-dependent oxidation of Pro into Delta1-pyrroline-5-carboxylate (P5C). Proline 0-3 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 23-28 20403182-2 2010 When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes. Proline 41-44 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 73-90 20403182-2 2010 When the cells are released from stress, Pro is degraded to glutamate by Pro-dehydrogenase (ProDH) and Pyrroline-5-carboxylate dehydrogenase (P5CDH), which are both mitochondrial enzymes in eukaryotes. Proline 41-44 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 92-97 21311034-2 2011 In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate. Proline 27-30 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 87-108 21311034-2 2011 In this catabolic pathway, Pro is converted to glutamate by two reactions catalyzed by proline dehydrogenase (ProDH) and Delta(1)-pyrroline-5-carboxylate dehydrogenase (P5CDH), with Delta(1)-pyrroline-5-carboxylate (P5C) as the intermediate. Proline 27-30 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 110-115 19710235-9 2009 Furthermore, cold acclimation up- and down-regulated expression of P5CS1 and ProDH genes, respectively, resulting in enhanced accumulation of proline (Pro) in wild-type plants. Proline 142-149 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 77-82 19635803-1 2009 The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate. Proline 26-33 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 130-151 19635803-1 2009 The two-step oxidation of proline in all eukaryotes is performed at the inner mitochondrial membrane by the consecutive action of proline dehydrogenase (ProDH) that produces Delta(1)-pyrroline-5-carboxylate (P5C) and P5C dehydrogenase (P5CDH) that oxidizes P5C to glutamate. Proline 26-33 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 153-158 17080945-7 2006 Expression of the A. thaliana ortholog of proline dehydrogenase (PDH), involved in proline catabolism, was undetectable in T. halophila shoots. Proline 42-49 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 65-68 17080945-8 2006 The PDH enzyme activity was lower and T. halophila seedlings were hypersensitive to exogenous proline, indicating repression of proline catabolism in T. halophila. Proline 128-135 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 4-7 9847097-1 1998 The cDNA clone ERD5 (early responsive to dehydration), isolated from 1-h-dehydrated Arabidopsis, encodes a precursor of proline (Pro) dehydrogenase (ProDH), which is a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid. Proline 129-132 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 15-19 12773641-0 2003 Toxicity of free proline revealed in an arabidopsis T-DNA-tagged mutant deficient in proline dehydrogenase. Proline 17-24 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 85-106 12376638-0 2002 ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis. Proline 39-46 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 96-101 12376638-0 2002 ACTCAT, a novel cis-acting element for proline- and hypoosmolarity-responsive expression of the ProDH gene encoding proline dehydrogenase in Arabidopsis. Proline 39-46 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 116-137 12376638-2 2002 We previously isolated from Arabidopsis a gene encoding Pro dehydrogenase (ProDH), a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid. Proline 56-59 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 75-80 12376638-4 2002 ProDH is also induced by L-Pro and hypoosmolarity. Proline 25-30 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 0-5 12376638-6 2002 We analyzed a DNA region that is located 5" to the transcription start site (a promoter region) of ProDH to identify cis-acting elements involved in L-Pro-induced and hypoosmolarity-induced expression in transgenic tobacco (Nicotiana tabacum) and Arabidopsis plants. Proline 149-154 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 99-104 12376638-7 2002 We found that a 9-bp sequence, ACTCATCCT, in the ProDH promoter is necessary for the efficient expression of ProDH in response to L-Pro and hypoosmolarity. Proline 130-135 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 49-54 12376638-7 2002 We found that a 9-bp sequence, ACTCATCCT, in the ProDH promoter is necessary for the efficient expression of ProDH in response to L-Pro and hypoosmolarity. Proline 130-135 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 109-114 12376638-8 2002 Moreover, ACTCAT is a core cis-acting element, which we have called Pro- or hypoosmolarity-responsive element (PRE), that is necessary for L-Pro-responsive and hypoosmolarity-responsive expression of ProDH. Proline 139-144 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 200-205 11148267-0 2000 Oscillation and regulation of proline content by P5CS and ProDH gene expressions in the light/dark cycles in Arabidopsis thaliana L. The fluctuation of proline content, and protein and mRNA levels of delta1-pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase (ProDH), both of which are involved in proline biosynthesis and degradation, in the shoots of Arabidopsis grown in light/dark cycles were demonstrated under salt-stressed and unstressed conditions. Proline 30-37 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 58-63 15047879-1 2004 A 6-bp sequence, ACTCAT, acts as a cis-acting element involved in hypoosmolarity- and proline-responsive expression of an Arabidopsis proline dehydrogenase (ProDH) gene. Proline 86-93 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 134-155 15047879-1 2004 A 6-bp sequence, ACTCAT, acts as a cis-acting element involved in hypoosmolarity- and proline-responsive expression of an Arabidopsis proline dehydrogenase (ProDH) gene. Proline 86-93 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 157-162 15065439-0 2004 [Increase in the level of proline and osmotic pressure of cytoplasm in transformed tobacco bearing an antisense suppressor of the proline dehydrogenase gene]. Proline 26-33 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 130-151 9847097-1 1998 The cDNA clone ERD5 (early responsive to dehydration), isolated from 1-h-dehydrated Arabidopsis, encodes a precursor of proline (Pro) dehydrogenase (ProDH), which is a mitochondrial enzyme involved in the first step of the conversion of Pro to glutamic acid. Proline 129-132 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 149-154 9003320-3 1996 In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH). Proline 75-82 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 114-135 9003320-3 1996 In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH). Proline 75-82 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 137-140 9003320-3 1996 In order to understand the mechanisms involved in regulating the levels of proline, we cloned and characterized a proline dehydrogenase (PDH) cDNA from Arabidopsis thaliana (AtPDH). Proline 75-82 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 174-179 8710950-5 1996 During recovery from osmotic stress, accumulated proline is rapidly oxidized to glutamate and the first step of this process is catalyzed by proline oxidase. Proline 49-56 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 141-156 8776899-0 1996 A nuclear gene encoding mitochondrial proline dehydrogenase, an enzyme involved in proline metabolism, is upregulated by proline but downregulated by dehydration in Arabidopsis. Proline 83-90 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 38-59 8776899-4 1996 Sequence analysis of an Arabidopsis cDNA clone, ERD5 (for early responsive to dehydration stress), isolated from plants dehydrated for 1 hr, revealed that it encodes a protein with identity to products of the yeast PUT1 (for proline utilization) gene (23.6% over 364 amino acids) and the Drosophila sluggish-A gene (34.5% over 255 amino acids). Proline 225-232 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 48-52 8776899-9 1996 Immunologically, we showed that the product of ERD5 is localized in the mitochondrial fraction and accumulates in response to proline in cultured cells. Proline 126-133 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 47-51 8776899-10 1996 Fusion genes for ERD5 and PUT1 complemented a put1 mutant of yeast, allowing put1 to grow with proline as the source of nitrogen. Proline 95-102 Methylenetetrahydrofolate reductase family protein Arabidopsis thaliana 17-21