PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12874286-0 2003 Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. Proline 26-33 Cbl proto-oncogene Homo sapiens 91-94 12874286-4 2003 This motif was indispensable for CIN85 binding to Cbl/Cbl-b, to other CIN85 SH3 domains" effectors, and for mediating an intramolecular interaction between the SH3-A domain and the proline-rich region of CIN85. Proline 181-188 Cbl proto-oncogene Homo sapiens 50-53 12941616-4 2003 Additional data indicate that the SH3 domain of PLCgamma1 binds to both canonical and noncanonical SH3 domain-binding sites in the proline-rich region of c-Cbl. Proline 131-138 Cbl proto-oncogene Homo sapiens 154-159 12839496-5 2003 Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy. Proline 96-103 Cbl proto-oncogene Homo sapiens 16-19 12839496-5 2003 Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy. Proline 96-103 Cbl proto-oncogene Homo sapiens 119-124 12618476-6 2003 CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding. Proline 41-48 Cbl proto-oncogene Homo sapiens 179-184 11494134-6 2001 The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain. Proline 10-17 Cbl proto-oncogene Homo sapiens 33-36 11964172-5 2002 Grb2-SH3 domains formed an association with the proline-rich sequences of Sos and Cbl in both resting and activated platelets, since the peptidimer abolished these associations. Proline 48-55 Cbl proto-oncogene Homo sapiens 82-85 11494134-6 2001 The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain. Proline 10-17 Cbl proto-oncogene Homo sapiens 145-148 10022120-1 1999 Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites. Proline 175-182 Cbl proto-oncogene Homo sapiens 0-3 11067845-5 2001 The c-Cbl-binding site for CMS mapped to the carboxyl terminus of c-Cbl and is different from the proline-rich region known to bind SH3-containing proteins. Proline 98-105 Cbl proto-oncogene Homo sapiens 4-9 10521482-3 1999 Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes. Proline 84-91 Cbl proto-oncogene Homo sapiens 31-36 10521482-3 1999 Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes. Proline 84-91 Cbl proto-oncogene Homo sapiens 198-203 10022120-1 1999 Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites. Proline 175-182 Cbl proto-oncogene Homo sapiens 30-33 9890943-5 1999 We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl. Proline 123-130 Cbl proto-oncogene Homo sapiens 39-42 9890943-5 1999 We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl. Proline 123-130 Cbl proto-oncogene Homo sapiens 146-149 9797470-2 1998 c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites. Proline 114-121 Cbl proto-oncogene Homo sapiens 0-5 9712732-6 1998 The interaction of this extended PLCgamma1 SH3 domain fusion protein with Cbl was shown to depend entirely upon the interaction of the domain with a proline-rich motif in Cbl, ruling out the possibility that amino acids adjacent to the core SH3 domain of PLCgamma1 provide independent Cbl binding. Proline 149-156 Cbl proto-oncogene Homo sapiens 74-77 9259313-10 1997 Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl. Proline 136-143 Cbl proto-oncogene Homo sapiens 89-92 9259313-10 1997 Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl. Proline 136-143 Cbl proto-oncogene Homo sapiens 161-164 9121472-1 1997 The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2. Proline 105-112 Cbl proto-oncogene Homo sapiens 33-38 9622055-5 1997 In the carboxy-terminal region, mammalian Cbl forms share a proline-rich stretch, conserved tyrosine residues, and a leucine zipper. Proline 60-67 Cbl proto-oncogene Homo sapiens 42-45 7592693-9 1995 Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2. Proline 71-78 Cbl proto-oncogene Homo sapiens 46-49 7592693-10 1995 These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through its SH3 domain with proline-rich regions of Cbl. Proline 147-154 Cbl proto-oncogene Homo sapiens 171-174 7791764-2 1995 One of the most rapidly tyrosine-phosphorylated polypeptides is the 120-kDa product of the proto-oncogene c-cbl, a cytosolic and cytoskeletal protein containing multiple proline-rich motifs that are potential binding sites for proteins containing Src homology 3 (SH3) domains. Proline 170-177 Cbl proto-oncogene Homo sapiens 108-111 1565471-7 1992 This results in the translation of a 72 kDa protein, compared with the 120 kDa protein encoded by full-length c-cbl, which lacks a portion of the proline-rich domain and the entire leucine zipper. Proline 146-153 Cbl proto-oncogene Homo sapiens 110-115 33512474-6 2021 Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants. Proline 80-87 Cbl proto-oncogene Homo sapiens 29-32 33512474-6 2021 Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants. Proline 80-87 Cbl proto-oncogene Homo sapiens 187-190 33627783-9 2021 Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells. Proline 47-54 Cbl proto-oncogene Homo sapiens 18-21 33627783-9 2021 Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells. Proline 47-54 Cbl proto-oncogene Homo sapiens 71-74 22310290-7 2012 CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3. Proline 40-47 Cbl proto-oncogene Homo sapiens 0-3 31123462-11 2019 Fine mapping revealed that the proline-rich domain of c-Cbl is critical for interaction with TRAF6. Proline 31-38 Cbl proto-oncogene Homo sapiens 54-59 19268472-3 2009 To understand the manifold interactions of CIN85, we present a detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b. Proline 146-153 Cbl proto-oncogene Homo sapiens 205-208 22315494-0 2012 CBL mutations in myeloproliferative neoplasms are also found in the gene"s proline-rich domain and in patients with the V617FJAK2. Proline 75-82 Cbl proto-oncogene Homo sapiens 0-3 22315494-7 2012 RESULTS: An initial screening of all coding exons of CBL, CBLB and CBLC in 44 V617FJAK2-negative samples revealed two new CBL mutations (p.C416W in the RING finger domain and p.A678V in the proline-rich domain). Proline 190-197 Cbl proto-oncogene Homo sapiens 53-56 21830225-2 2011 The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction. Proline 4-11 Cbl proto-oncogene Homo sapiens 37-42 17237826-4 2007 Our studies indicate that localization of c-Cbl to the membrane is likely to be mediated by the tyrosine kinase binding (TKB) domain and the proline-rich region of c-Cbl, whereas C-terminal tyrosine phosphorylation does not play a role. Proline 141-148 Cbl proto-oncogene Homo sapiens 42-47 18680311-2 2008 The SH3 domains of CIN85 bind to a proline-rich region of Cbl. Proline 35-42 Cbl proto-oncogene Homo sapiens 58-61 17094785-4 2006 Mutating prolines 543-548 reduced Src binding to the Cbl 479-636 fragment significantly more than mutating the prolines in the PPVPPR(494-499) motif, which was previously reported to bind Src SH3. Proline 9-17 Cbl proto-oncogene Homo sapiens 53-56 17094785-2 2006 We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl. Proline 135-142 Cbl proto-oncogene Homo sapiens 66-69 17094785-2 2006 We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl. Proline 135-142 Cbl proto-oncogene Homo sapiens 161-164 17094785-5 2006 Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl. Proline 13-21 Cbl proto-oncogene Homo sapiens 9-12 17094785-5 2006 Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl. Proline 13-21 Cbl proto-oncogene Homo sapiens 79-82 17094785-5 2006 Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl. Proline 13-21 Cbl proto-oncogene Homo sapiens 79-82 17094785-5 2006 Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl. Proline 13-21 Cbl proto-oncogene Homo sapiens 79-82 16906159-4 2006 In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL. Proline 137-144 Cbl proto-oncogene Homo sapiens 170-173 16407834-3 2006 Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase. Proline 74-81 Cbl proto-oncogene Homo sapiens 142-145 16228008-2 2005 Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis. Proline 117-124 Cbl proto-oncogene Homo sapiens 143-146 15872089-5 2005 The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl. Proline 202-209 Cbl proto-oncogene Homo sapiens 146-149 15872089-5 2005 The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl. Proline 202-209 Cbl proto-oncogene Homo sapiens 146-149