PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25258030-2 2015 A single nucleotide polymorphism (SNP) at rs16139 (T1128C) within the NPY-gene identified an amino acid substitution from leucine (L) to proline (P) (L7P) associated with both glucose tolerance and type 2 diabetes. Proline 137-144 neuropeptide Y Homo sapiens 70-73 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 55-62 neuropeptide Y Homo sapiens 98-112 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 55-62 neuropeptide Y Homo sapiens 114-117 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 66-73 neuropeptide Y Homo sapiens 98-112 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 66-73 neuropeptide Y Homo sapiens 114-117 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 66-73 neuropeptide Y Homo sapiens 98-112 24201779-7 2014 RESULTS: After adjustment for confounders, the leucine/proline or proline/proline genotype of the neuropeptide Y (NPY) gene rs16139 was associated with a lower risk than the leucine/leucine genotype (odds ratio, 0.40 [95% confidence interval, 0.15-0.91]). Proline 66-73 neuropeptide Y Homo sapiens 114-117 21746772-0 2011 Inflammatory effects of blood leukocytes: association with vascular function in neuropeptide Y proline 7-genotyped type 2 diabetes patients. Proline 95-102 neuropeptide Y Homo sapiens 80-94 26952950-2 2012 A well-known polymorphism encoding the substitution of leucine to proline in the signal peptide sequence of NPY (Leu7Pro variation) was previously found to protect against depression. Proline 66-73 neuropeptide Y Homo sapiens 108-111 12932169-0 2003 Leucine 7 to proline 7 polymorphism of the preproneuropeptide Y gene is not associated with restenosis after coronary stenting. Proline 13-20 neuropeptide Y Homo sapiens 43-63 20042335-1 2010 We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R). Proline 57-60 neuropeptide Y Homo sapiens 27-41 20042335-1 2010 We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R). Proline 57-60 neuropeptide Y Homo sapiens 43-46 20042335-1 2010 We substituted a truncated neuropeptide Y (NPY) analog, [Pro(30), Tyr(32), Leu(34)]NPY(28-36)NH(2) also called BVD15, at various positions with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7-10-tetraacetic acid) and evaluated the effect of the coupling position with the binding affinity for NPY Y(1) receptors (NPY1R). Proline 57-60 neuropeptide Y Homo sapiens 83-86 21284559-6 2011 The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively. Proline 76-83 neuropeptide Y Homo sapiens 33-47 21284559-6 2011 The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively. Proline 76-83 neuropeptide Y Homo sapiens 49-52 18279562-0 2008 Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD. Proline 13-20 neuropeptide Y Homo sapiens 43-57 11334558-0 2001 Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90). Proline 83-86 neuropeptide Y Homo sapiens 44-47 11814622-2 2002 The Y(1) receptor agonist, [Leu(31),Pro(34)]-NPY, inhibited forskolin-stimulated cAMP production which was insensitive to thapsigargin or the CaM kinase II inhibitor, KN-93. Proline 36-39 neuropeptide Y Homo sapiens 45-48 12069594-1 2002 The structure of [Ala(31), Pro(32)]-NPY, a neuropeptide Y mutant with selectivity for the NPY Y(5)-receptor (Cabrele, C., Wieland, H. A., Stidsen, C., Beck-Sickinger, A. G., (2002) Biochemistry XX, XXXX-XXXX (companion paper)), has been characterized in the presence of the membrane mimetic dodecylphosphocholine (DPC) micelles using high-resolution NMR techniques. Proline 27-30 neuropeptide Y Homo sapiens 36-39 12069594-11 2002 However, signal reductions due to efficient electron, nuclear spin relaxation were much less pronounced for the surface-averted residues in [Ala(31), Pro(32)]-NPY when compared to wild-type DPC-bound NPY. Proline 150-153 neuropeptide Y Homo sapiens 159-162 12069594-13 2002 The postulation of a different membrane binding mode of [Ala(31), Pro(32)]-NPY is further supported by the faster H/D exchange at the C-terminal amide protons. Proline 66-69 neuropeptide Y Homo sapiens 75-78 11814622-7 2002 Consistently, [Leu(31),Pro(34)]-NPY induced trans-CREB mediated luciferase activity through a CaM kinase dependent pathway, and inhibited forskolin-stimulated luciferase gene expression. Proline 23-26 neuropeptide Y Homo sapiens 32-35 11696660-3 2001 A recent study indicated that the NPY gene variant producing a leucine-to-proline substitution (T to C at position 1128) was associated with 34% higher average alcohol consumption. Proline 74-81 neuropeptide Y Homo sapiens 34-37 11696660-7 2001 CONCLUSIONS: We speculate that the genetic polymorphism producing the proline(7) substitution of NPY might not predispose to alcoholism, but indeed retard the transition to alcoholism. Proline 70-77 neuropeptide Y Homo sapiens 97-100 11422604-0 2001 A leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y was not identified in the Japanese population. Proline 16-23 neuropeptide Y Homo sapiens 65-79 11422604-1 2001 OBJECTIVE: A Leu(7)-to-Pro(7) polymorphism exists in the signal peptide part of prepro-neuropeptide Y (NPY) and this polymorphism is associated with high serum cholesterol and LDL cholesterol levels in both Finnish and Dutch people. Proline 23-26 neuropeptide Y Homo sapiens 80-101 11422604-1 2001 OBJECTIVE: A Leu(7)-to-Pro(7) polymorphism exists in the signal peptide part of prepro-neuropeptide Y (NPY) and this polymorphism is associated with high serum cholesterol and LDL cholesterol levels in both Finnish and Dutch people. Proline 23-26 neuropeptide Y Homo sapiens 103-106 11422604-8 2001 CONCLUSION: The incidence of the Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY was extremely low in Japanese people, suggesting that the polymorphism producing Pro(7) is not one of the genetic determinant factors affecting serum cholesterol levels in Japanese people. Proline 43-46 neuropeptide Y Homo sapiens 88-91 11078884-4 2000 Furthermore, porcine [Leu(31), Pro(34)]NPY, which binds poorly to mammalian Y2, exhibited an unexpectedly high affinity for chicken Y2. Proline 31-34 neuropeptide Y Homo sapiens 39-42 10841982-0 2000 The leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y is not associated with Alzheimer"s disease or the link apolipoprotein E. Proline 19-26 neuropeptide Y Homo sapiens 69-83 9846584-0 1998 Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels. Proline 31-38 neuropeptide Y Homo sapiens 80-94 10852461-0 2000 Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects. Proline 13-20 neuropeptide Y Homo sapiens 43-57 9920351-4 1998 A newly discovered association between a leucine(7)-to-proline(7) polymorphism (Pro(7)) in the signal peptide of NPY and a high cholesterol level may provide new ideas for the genetic regulation of cholesterol metabolism. Proline 55-62 neuropeptide Y Homo sapiens 113-116 10926322-0 2000 Leucine 7 to proline 7 polymorphism in the neuropeptide y gene is associated with retinopathy in type 2 diabetes. Proline 13-20 neuropeptide Y Homo sapiens 43-57 9846584-5 1998 We report here the identification of a common Leu(7)-to-Pro(7) polymorphism in the signal peptide of NPY. Proline 56-59 neuropeptide Y Homo sapiens 101-104 7766824-0 1995 Conformational properties of the proline region of porcine neuropeptide Y by CD and 1H-nmr spectroscopy. Proline 33-40 neuropeptide Y Homo sapiens 59-73 8897476-5 1996 These approaches reveal that NPY is processed at its N-terminus by two proline-preferring aminopeptidases: aminopeptidase P and dipeptidyl peptidase IV. Proline 71-78 neuropeptide Y Homo sapiens 29-32 7473586-10 1995 This suggests that the selectivity of NPY receptors is highly dependent on subtle conformational changes such as the substitution of residue 34 to a proline or the introduction of intramolecular constraints. Proline 149-156 neuropeptide Y Homo sapiens 38-41 7907802-1 1993 Neuropeptide Y, peptide YY and pancreatic polypeptide share an evolutionary conserved proline-rich N-terminal sequence, a structure generally known to be inert to the attack of common proteinases, but a potential target for specialized proline-specific aminopeptidases. Proline 86-93 neuropeptide Y Homo sapiens 0-14 7907802-1 1993 Neuropeptide Y, peptide YY and pancreatic polypeptide share an evolutionary conserved proline-rich N-terminal sequence, a structure generally known to be inert to the attack of common proteinases, but a potential target for specialized proline-specific aminopeptidases. Proline 236-243 neuropeptide Y Homo sapiens 0-14 1569926-2 1992 The Y1 receptor-specific agonist (Leu-31,Pro-34)-NPY is 4-fold more potent and the carboxyl-terminal fragment NPY13-36 is 150-fold less potent than NPY. Proline 41-44 neuropeptide Y Homo sapiens 49-52 29494882-4 2018 Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness. Proline 59-66 neuropeptide Y Homo sapiens 128-131 29494882-4 2018 Specifically, the minor G-allele of the SNP, which encodes proline instead of leucine and leads to higher processing of pre-pro NPY into mature NPY, was associated with higher levels of conscientiousness. Proline 59-66 neuropeptide Y Homo sapiens 144-147