PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32468886-7 2020 Domain swap experiments mixing SH2 (phosphotyrosine binding) and SH3 (proline-rich binding) domains between Nck1 and Nck2 showed a dispensable role for SH2 domains but a critical role for the Nck1 SH3 domains in rescuing disturbed flow-induced endothelial permeability. Proline 70-77 NCK adaptor protein 1 Homo sapiens 108-112 33917227-4 2021 Lck binds to a receptor kinase (RK) motif and Nck binds to a proline-rich sequence (PRS). Proline 61-68 NCK adaptor protein 1 Homo sapiens 46-49 26553976-3 2015 The adaptor protein Nck has three SRC-homology 3 (SH3) domains that bind multiple proline-rich segments in the actin regulatory protein neuronal Wiskott-Aldrich syndrome protein (N-WASP) and an SH2 domain that binds to multiple phosphotyrosine sites in the adhesion protein nephrin, leading to phase separation. Proline 82-89 NCK adaptor protein 1 Homo sapiens 20-23 28003549-2 2016 Antigen binding to the T cell receptor (TCR) triggers the recruitment of the cytosolic adaptor protein Nck to a proline-rich sequence in the cytoplasmic tail of the TCR"s CD3epsilon subunit. Proline 112-119 NCK adaptor protein 1 Homo sapiens 103-106 30166341-4 2018 CE is recruited to the cytoplasmic capping complex by binding of a C-terminal proline-rich sequence to the third Src homology 3 (SH3) domain of NCK adapter protein 1 (NCK1). Proline 78-85 NCK adaptor protein 1 Homo sapiens 167-171 21664272-3 2011 The first and the third SH3 domains of Nck1 and the NH(2)-terminal proline-rich sequence of RasGAP contribute most to the complex formation causing direct molecular interaction between the two proteins. Proline 67-74 NCK adaptor protein 1 Homo sapiens 39-43 26163016-5 2015 In addition, the SH3 domains of Nck interacted with the proline rich region (PRR) of TSAd. Proline 56-63 NCK adaptor protein 1 Homo sapiens 32-35 23673634-3 2013 Here we identify an atypical proline-rich motif in chimaerins that binds to the adaptor protein Nck1. Proline 29-36 NCK adaptor protein 1 Homo sapiens 96-100 22534133-8 2012 A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery. Proline 24-31 NCK adaptor protein 1 Homo sapiens 82-85 22534133-8 2012 A point mutation in the proline-rich site of Vav1, which abolishes its binding to Nck, impaired actin rearrangement, suggesting that Nck-Vav1 dimers play a critical role in regulation of the actin machinery. Proline 24-31 NCK adaptor protein 1 Homo sapiens 133-136 25137142-0 2014 The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme. Proline 79-86 NCK adaptor protein 1 Homo sapiens 61-65 25137142-2 2014 We identify the proline-rich C-terminus as a new domain of CE that is required for its participation in cytoplasmic capping, and show the cytoplasmic capping complex assembles on Nck1, an adapter protein with functions in translation and tyrosine kinase signaling. Proline 16-23 NCK adaptor protein 1 Homo sapiens 179-183 23181695-7 2012 Upon activation of the receptor kinase, the SH2 domain of Nck binds to one of its tyrosine residues, while Nck SH3 domains interact with the proline-rich domain of Caskin1. Proline 141-148 NCK adaptor protein 1 Homo sapiens 107-110 23162739-3 2012 Their proline-rich motifs bind SH3 adaptor proteins such as PIX and NCK. Proline 6-13 NCK adaptor protein 1 Homo sapiens 68-71 11340081-2 2001 The Nck Src homology (SH) 2/3 adaptor binds via its SH3 domains to a proline-rich region on WASP and N-WASP and has been implicated in recruitment of these proteins to sites of tyrosine phosphorylation. Proline 69-76 NCK adaptor protein 1 Homo sapiens 4-7 12110186-4 2002 We present strong evidence that ligand engagement of TCR-CD3 induces a conformational change that exposes a proline-rich sequence in CD3 epsilon and results in recruitment of the adaptor protein Nck. Proline 108-115 NCK adaptor protein 1 Homo sapiens 195-198 20527928-7 2010 This intramolecular interaction could, at least partially, explain the remarkable specificity of Nck toward proteins with proline-rich sequences. Proline 122-129 NCK adaptor protein 1 Homo sapiens 97-100 16636066-1 2006 Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that modulate actin cytoskeleton dynamics by linking proline-rich effector molecules to tyrosine kinases or phosphorylated signaling intermediates. Proline 132-139 NCK adaptor protein 1 Homo sapiens 0-3 16595635-5 2006 Nck binds to the proline-rich portion of FasL and alters its subcellular distribution when coexpressed in 293T cells. Proline 17-24 NCK adaptor protein 1 Homo sapiens 0-3 12614350-6 2003 One of the hallmarks of these early changes in TCR conformation is the induced recruitment of the adapter protein Nck to a proline-rich sequence of the cytoplasmic tail of CD3epsilon, but there may be others. Proline 123-130 NCK adaptor protein 1 Homo sapiens 114-117 10229072-1 1999 The Nck adaptor protein links tyrosine kinases or their substrates to proteins containing proline-rich motifs. Proline 90-97 NCK adaptor protein 1 Homo sapiens 4-7 10393272-2 1999 The major function of these adaptors, such as Grb2, Nck, and Crk, is to recruit proline-rich effector molecules to tyrosine-phosphorylated kinases or their substrates. Proline 80-87 NCK adaptor protein 1 Homo sapiens 52-55 10747847-5 2000 A central proline-rich motif associated with the Src homology (SH)2/SH3-containing adapter proteins Grb2 and Nck in vivo, whereas a pleckstrin homology (PH) domain was located at the GEF C terminus. Proline 10-17 NCK adaptor protein 1 Homo sapiens 109-112 9694849-2 1998 Nck links, via its SH2 domain, tyrosine-phosphorylated receptors to effector proteins that contain SH3-binding proline-rich sequences. Proline 111-118 NCK adaptor protein 1 Homo sapiens 0-3 9344857-3 1997 A novel molecule detected therefrom (referred to as Nck-, Ash- and phospholipase Cgamma-binding protein 4) contained proline-rich sequences and, through the function of one of them, interacted with the middle SH3 domain of Nck. Proline 117-124 NCK adaptor protein 1 Homo sapiens 52-55 9344857-3 1997 A novel molecule detected therefrom (referred to as Nck-, Ash- and phospholipase Cgamma-binding protein 4) contained proline-rich sequences and, through the function of one of them, interacted with the middle SH3 domain of Nck. Proline 117-124 NCK adaptor protein 1 Homo sapiens 223-226 34124074-4 2021 The Nck SH3 domains interact with signaling effectors containing proline-rich regions that mediate their activation by upstream kinases. Proline 65-72 NCK adaptor protein 1 Homo sapiens 4-7 8798379-4 1996 The association between Nck and Pak1 is mediated by the second SH3 domain of Nck and a proline-rich sequence in the amino terminus of Pak1. Proline 87-94 NCK adaptor protein 1 Homo sapiens 24-27