PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24391960-2 2013 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 25329792-1 2014 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 25329792-1 2014 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 25128817-1 2015 Cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, requires p39 for its enzymatic activity, and is implicated in cytoskeletal organization and contraction in numerous cell types. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 0-25 25128817-1 2015 Cyclin dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, requires p39 for its enzymatic activity, and is implicated in cytoskeletal organization and contraction in numerous cell types. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 27-31 25807947-2 2015 One important kinase at the synapse is the proline-directed serine/ threonine kinase Cdk5. Proline 43-50 cyclin dependent kinase 5 Homo sapiens 85-89 24498195-1 2014 Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity participates in the regulation of nociceptive signaling. Proline 31-38 cyclin dependent kinase 5 Homo sapiens 0-25 24391960-2 2013 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase whose function has been implicated in the brain reward circuit. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 24235147-4 2013 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 24235147-4 2013 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine-threonine kinase that is involved in various neuronal processes. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 24121667-2 2013 CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression. Proline 10-17 cyclin dependent kinase 5 Homo sapiens 0-4 24085300-8 2013 Three amino acids of p35, Asp-259, Asn-266, and Ser-270, which are involved in hydrogen bond formation with Cdk5, are changed to Gln, Gln, and Pro in p39. Proline 143-146 cyclin dependent kinase 5 Homo sapiens 108-112 23362255-5 2013 Tau phosphorylation occurs mainly at proline-directed Ser/Thr sites, which are targeted by protein kinases such as GSK3beta and Cdk5. Proline 37-44 cyclin dependent kinase 5 Homo sapiens 128-132 23362255-6 2013 We reported previously that dephosphorylation of Tau at Cdk5-mediated sites was enhanced by Pin1, a peptidyl-prolyl isomerase that stimulates dephosphorylation at proline-directed sites by protein phosphatase 2A. Proline 163-170 cyclin dependent kinase 5 Homo sapiens 56-60 22795893-1 2012 Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases with no evident role in cell cycle progression. Proline 88-95 cyclin dependent kinase 5 Homo sapiens 25-29 22795893-1 2012 Cyclin-dependent kinase, Cdk5, is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases with no evident role in cell cycle progression. Proline 88-95 cyclin dependent kinase 5 Homo sapiens 25-28 20061803-1 2010 Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. Proline 48-55 cyclin dependent kinase 5 Homo sapiens 26-30 28066692-4 2012 A proline-directed serine/threonine (S/T) kinase, predominantly active in the nervous system, Cdk5 regulates a multitude of functions including nervous system development, neuronal migration, cytoskeletal dynamics, axonal guidance, synaptic plasticity, neurotransmission, neuronal survival and death, to mention a few. Proline 2-9 cyclin dependent kinase 5 Homo sapiens 94-98 21144757-5 2011 Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs. Proline 122-129 cyclin dependent kinase 5 Homo sapiens 0-25 21144757-5 2011 Cyclin dependent kinase 5 (CDK5), when activated by the regulatory binding protein p25, phosphorylates tau at a number of proline-directed serine/threonine residues, resulting in formation of phosphorylated tau as paired helical filaments (PHFs) then in subsequent deposition of PHFs as NFTs. Proline 122-129 cyclin dependent kinase 5 Homo sapiens 27-31 21924349-1 2012 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal guidance, and synaptic plasticity, among other processes. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 21924349-1 2012 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is mostly active in the nervous system, where it regulates several processes such as neuronal migration, actin and microtubule dynamics, axonal guidance, and synaptic plasticity, among other processes. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 21145377-1 2011 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts with a myriad of substrates. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 21145377-1 2011 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that is ubiquitous in the nervous system and interacts with a myriad of substrates. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 21056617-10 2011 The proline switch in the tau conformation triggers dephosphorylation of Ser/Thr residues phosphorylated, e.g. by two well-known tau kinases Cdk5 and GSK-3beta. Proline 4-11 cyclin dependent kinase 5 Homo sapiens 141-145 21044075-1 2010 Cyclin-dependent kinase (Cdk)5 is a proline-directed Ser/Thr protein kinase that functions mainly in neurons and is activated by binding to a regulatory subunit, p35 or p39. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 0-30 20717630-1 2010 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 20717630-1 2010 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, and plays multiple roles in neuron development and synaptic plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 18183483-1 2008 The proline-directed serine threonine kinase, Cdk5, is an unusual molecule that belongs to the well-known large family of proteins, cyclin-dependent kinases (Cdks). Proline 4-11 cyclin dependent kinase 5 Homo sapiens 46-50 19457112-2 2009 Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase involved not only in neuronal development, but also in synaptic function and plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 19457112-2 2009 Cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase involved not only in neuronal development, but also in synaptic function and plasticity. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 19343042-1 2009 Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 0-25 19343042-1 2009 Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 27-31 18490454-6 2008 Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide. Proline 46-53 cyclin dependent kinase 5 Homo sapiens 10-14 18490454-6 2008 Moreover, Cdk5 (cyclin-dependent kinase 5), a proline-directed Ser/Thr kinase, additionally increases p53 stability via post-translational modification of p53 in response to hydrogen peroxide. Proline 46-53 cyclin dependent kinase 5 Homo sapiens 16-41 17394551-1 2007 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase that plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 18388733-3 2008 Cyclin-dependent kinase 5 (Cdk5) is a postmitotic proline-directed serine/threonine kinase that hyperphosphorylates tau under pathological conditions. Proline 50-57 cyclin dependent kinase 5 Homo sapiens 0-25 18388733-3 2008 Cyclin-dependent kinase 5 (Cdk5) is a postmitotic proline-directed serine/threonine kinase that hyperphosphorylates tau under pathological conditions. Proline 50-57 cyclin dependent kinase 5 Homo sapiens 27-31 18076569-2 2007 Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase also involved in neuronal migration. Proline 42-49 cyclin dependent kinase 5 Homo sapiens 0-25 18076569-2 2007 Cyclin-dependent kinase 5 (Cdk5)-p35 is a proline-directed Ser/Thr kinase also involved in neuronal migration. Proline 42-49 cyclin dependent kinase 5 Homo sapiens 27-31 17394551-1 2007 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed Ser/Thr kinase that plays important roles in various neuronal activities, including neuronal migration, synaptic activity, and neuronal cell death. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 16029324-1 2005 BACKGROUND: CDK5 is a member of proline-directed serine/threonine kinases. Proline 32-39 cyclin dependent kinase 5 Homo sapiens 12-16 17591690-3 2007 Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of roles in neuronal degeneration. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 0-25 17591690-3 2007 Cyclin-dependent kinase 5 (Cdk5), a proline-directed serine/threonine kinase, is most active in the central nervous system and plays a variety of roles in neuronal degeneration. Proline 36-43 cyclin dependent kinase 5 Homo sapiens 27-31 16407116-2 2006 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 16407116-2 2006 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase implicated in the development and disease of the mammalian nervous system. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 17526057-1 2007 Since the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Proline 62-69 cyclin dependent kinase 5 Homo sapiens 23-48 17526057-1 2007 Since the isolation of cyclin-dependent kinase 5 (Cdk5), this proline-directed serine/threonine kinase has been demonstrated as an important regulator of neuronal migration, neuronal survival and synaptic functions. Proline 62-69 cyclin dependent kinase 5 Homo sapiens 50-54 15342635-1 2004 The complex of Cdk5 and its neuronal activator p35 is a proline-directed Ser/Thr kinase that plays an important role in various neuronal functions. Proline 56-63 cyclin dependent kinase 5 Homo sapiens 15-19 15023357-3 2004 Cdk5, however, is unique to this family of proline-directed serine/threonine kinases on two accounts. Proline 43-50 cyclin dependent kinase 5 Homo sapiens 0-4 15123626-1 2004 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 15123626-1 2004 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine protein kinase that requires association with a regulatory protein, p35 or p39, to form an active enzyme. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 8702879-4 1996 To identify the kinase involved, three proline-directed protein kinases expressed highly in the brain, i.e. mitogen-activated protein (MAP) kinase, Cdk5-p23, and glycogen synthase kinase 3beta, were tested for the in vitro phosphorylation of synapsin I. Proline 39-46 cyclin dependent kinase 5 Homo sapiens 148-152 10386957-7 1999 These results demonstrate that CDK-5 is a major proline-directed kinase phosphorylating the human NF-H tail domain. Proline 48-55 cyclin dependent kinase 5 Homo sapiens 31-36 10413323-2 1999 Many of the phosphorylation sites on tau are serine/threonine-proline sequences, several of which are phosphorylated in vitro by neuronal Cdc2-like kinase (Nclk), a kinase composed of Cdk5 and its activator(s). Proline 62-69 cyclin dependent kinase 5 Homo sapiens 184-188 11248668-9 2001 Cdk5 has been characterized as a proline-directed Ser/Thr protein kinase, that contributes to phosphorylation of human tau on Ser202, Thr205, Ser235 and Ser404. Proline 33-40 cyclin dependent kinase 5 Homo sapiens 0-4 9378721-0 1997 Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. Proline 32-39 cyclin dependent kinase 5 Homo sapiens 99-103 9378721-3 1997 For cdk5, these substitutions led to parallel effects on the K(m) value to those found for cdc2 kinase; cdk5 recognized the peptides with a proline specificity similar to that for cdc2 kinase. Proline 140-147 cyclin dependent kinase 5 Homo sapiens 4-8 9378721-3 1997 For cdk5, these substitutions led to parallel effects on the K(m) value to those found for cdc2 kinase; cdk5 recognized the peptides with a proline specificity similar to that for cdc2 kinase. Proline 140-147 cyclin dependent kinase 5 Homo sapiens 104-108 9378721-4 1997 These results suggest that the pyrrolidine ring of proline is important for substrate recognition by cdc2 kinase or cdk5. Proline 51-58 cyclin dependent kinase 5 Homo sapiens 116-120 9378721-6 1997 The results obtained here also suggest that the pyrrolidine ring of proline is required to maintain a high V(max) value for cdc2 kinase or especially for cdk5. Proline 68-75 cyclin dependent kinase 5 Homo sapiens 154-158 28877958-8 2018 We confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6. Proline 48-55 cyclin dependent kinase 5 Homo sapiens 78-103 7566345-2 1995 Tau can be phosphorylated at many sites and by several kinases, notably by proline-directed kinases (MAPK, GSK-3, cdk5) which generate Alzheimer-like antibody epitopes. Proline 75-82 cyclin dependent kinase 5 Homo sapiens 114-118 34814918-1 2021 Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function. Proline 10-17 cyclin dependent kinase 5 Homo sapiens 0-4 29288339-3 2018 Cdk5 is a proline-directed Ser/Thr kinase involved in the regulation of synaptic plasticity and memory processes that has been associated with several neurodegenerative disorders. Proline 10-17 cyclin dependent kinase 5 Homo sapiens 0-4 32286796-1 2020 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has been demonstrated to be one of the most diversely functional kinases within neurons. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 32286796-1 2020 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine (ser)/threonine (Thr) kinase that has been demonstrated to be one of the most diversely functional kinases within neurons. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 28877958-8 2018 We confirmed serine 14 as a target of MAPKs and proline-directed kinases like cyclin-dependent kinase 5 (Cdk5) in cell-based as well as in vitro kinase assays and quantitative phosphoproteomic analysis of TRPC6. Proline 48-55 cyclin dependent kinase 5 Homo sapiens 105-109 26601962-1 2016 Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 27345869-5 2016 Considering the potential involvement of the T/SP motifs as putative phosphorylation sites, we also show that proline-directed Ser/Thr kinase CDK5 modulates the activity of TRPA1, and that T673 outside the AR-domain is its only possible target. Proline 110-117 cyclin dependent kinase 5 Homo sapiens 142-146 26206088-1 2016 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 26206088-1 2016 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase and its dysregulation is implicated in neurodegenerative diseases. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 29111393-1 2018 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 0-25 29111393-1 2018 Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 26601962-1 2016 Cyclin-dependent kinase 5 (CDK5) is a proline-directed serine/threonine kinase belonging to the family of cyclin-dependent kinases. Proline 38-45 cyclin dependent kinase 5 Homo sapiens 27-31 26555036-7 2015 RESULTS: The close proximity of Arg/Lys amino acids and a proline two residues N-terminal to the phosphorylated residue both improve recognition of the substrate by CDK5. Proline 58-65 cyclin dependent kinase 5 Homo sapiens 165-169