PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34288034-1 2021 AIM: Splicing factor proline and glutamine rich (SFPQ) is an RNA-DNA binding protein that is dysregulated in Alzheimer"s disease and frontotemporal dementia. Proline 21-28 splicing factor proline and glutamine rich Homo sapiens 49-53 8371983-7 1993 In addition, both p54nrb and PSF are rich in Pro and Gln residues outside the main homology region. Proline 45-48 splicing factor proline and glutamine rich Homo sapiens 29-32 34404863-2 2021 Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-binding protein (RBP) implicated in the regulation of gene expression pathways and intracellular trafficking. Proline 16-23 splicing factor proline and glutamine rich Homo sapiens 40-44 32577828-4 2020 We show that one of these identified proteins, splicing factor proline and glutamine rich (SFPQ), is downregulated in the post-mortem brains of rapidly progressive AD patients, sCJD patients and 3xTg mice brain at terminal stage of the disease. Proline 63-70 splicing factor proline and glutamine rich Homo sapiens 91-95 35274674-12 2022 Next, we assessed splicing factor proline/glutamine rich (SFPQ) expression in spinal cord motor neurons; SFPQ is a recently-identified regulator of ALS/FTLD pathogenesis, and it is also reported that interaction between SFPQ and fused-in-sarcoma (FUS) regulates splicing of microtubule-associated protein tau exon 10. Proline 34-41 splicing factor proline and glutamine rich Homo sapiens 58-62 35274674-12 2022 Next, we assessed splicing factor proline/glutamine rich (SFPQ) expression in spinal cord motor neurons; SFPQ is a recently-identified regulator of ALS/FTLD pathogenesis, and it is also reported that interaction between SFPQ and fused-in-sarcoma (FUS) regulates splicing of microtubule-associated protein tau exon 10. Proline 34-41 splicing factor proline and glutamine rich Homo sapiens 105-109 33476259-2 2021 Here, we identify two factors, splicing factor proline/glutamine rich (SFPQ) and non-POU domain-containing octamer-binding protein (NONO), to be enriched around circRNA loci. Proline 47-54 splicing factor proline and glutamine rich Homo sapiens 71-75 32950106-7 2021 NONO directly interacted with splicing factor proline/glutamine rich (SFPQ) to regulate the splicing of SETMAR, and it induced metastasis suppression of bladder cancer cells. Proline 46-53 splicing factor proline and glutamine rich Homo sapiens 70-74 30725116-5 2019 In response to 20 microM etoposide, the DNA/RNA-binding protein, non-POU domain-containing octamer-binding protein (NONO) and its dimerization partner splicing factor, proline/glutamine-rich (SFPQ) formed complexes with IGFBP-3, demonstrated in basal-like TNBC cell lines HCC1806 and MDA-MB-468. Proline 168-175 splicing factor proline and glutamine rich Homo sapiens 192-196 32661324-6 2020 Mechanistically, LINC01503 recruited splicing factor proline-and glutamine-rich (SFPQ) to activate Fos like 1 (FOSL1) transcription, and ectopic expression of FOSL1 reversed the suppressive effect of LINC01503 knockdown on NPC progression. Proline 53-60 splicing factor proline and glutamine rich Homo sapiens 81-85 32332923-4 2020 We identified the splicing factor proline and glutamine rich (SFPQ) as a critical mediator of response to PT in an unbiased functional genomic screening in EOC cells and, using a large cohort of primary and recurrent EOC samples, we observed that it is frequently overexpressed in recurrent PT-treated samples and that its overexpression correlates with PT resistance. Proline 34-41 splicing factor proline and glutamine rich Homo sapiens 62-66 31393052-5 2019 Besides, sCD40L stimulation decreases splicing factor proline- and glutamine-rich protein (SFPQ) protein (one member of DBHS protein family) expression, while SFPQ overexpression suppresses sCD40L stimulation-induced proliferation and migration of pulmonary adventitial fibroblasts by repressing CD40 transcription. Proline 54-61 splicing factor proline and glutamine rich Homo sapiens 91-95 30661786-3 2019 SFPQ, a proline and glutamine rich splicing factor that participates in diverse molecular functions including paraspeckle formation, microRNA synthesis and transcription regulation, is known to regulate host innate immune response to viruses. Proline 8-15 splicing factor proline and glutamine rich Homo sapiens 0-4 30939845-8 2019 Interestingly, expression of various spliceosome genes is enhanced by RNA-binding protein splicing factor proline- and glutamine-rich (PSF/SFPQ), leading to changes in the expression of AR transcript variants. Proline 106-113 splicing factor proline and glutamine rich Homo sapiens 135-138 30939845-8 2019 Interestingly, expression of various spliceosome genes is enhanced by RNA-binding protein splicing factor proline- and glutamine-rich (PSF/SFPQ), leading to changes in the expression of AR transcript variants. Proline 106-113 splicing factor proline and glutamine rich Homo sapiens 139-143 30142213-5 2018 The multifunctional splicing factor proline and glutamine rich (SFPQ) was identified as one such protein. Proline 36-43 splicing factor proline and glutamine rich Homo sapiens 64-68 27095734-6 2016 Proteins involved in RNA splicing such as serine/arginine-rich splicing factor 2 (SRSF2) and splicing factor and proline- and glutamine-rich (SFPQ) were stabilized with DMOG. Proline 113-120 splicing factor proline and glutamine rich Homo sapiens 142-146 30026827-12 2018 Splicing factor proline and glutamine rich (SFPQ), a novel RNA binding protein, was identified as a direct target gene of miR-1296 in CRC. Proline 16-23 splicing factor proline and glutamine rich Homo sapiens 44-48 28743736-3 2017 In this study, we investigated the transcriptional regulation of PDE3A , and found that the splicing factor proline and glutamine rich (SFPQ) protein modulated PDE3A mRNA levels. Proline 108-115 splicing factor proline and glutamine rich Homo sapiens 136-140 24173718-6 2014 In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription. Proline 67-74 splicing factor proline and glutamine rich Homo sapiens 91-95 21565176-8 2011 Using these techniques we identified two splicing factor proteins, serine/arginine-rich splicing factor 3 (SRSF3) and splicing factor proline/glutamine-rich (SFPQ), that induced resistance to dFdC as well as other pyrimidine nucleoside analogs when their expression was decreased in HeLa cells. Proline 134-141 splicing factor proline and glutamine rich Homo sapiens 158-162 20421926-7 2010 In contrast, the expression of two proteins involved in RNA processing, the Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) and the Splicing factor proline/glutamine-rich (SFPQ), was higher in Snail1-expressing cells than in controls. Proline 166-173 splicing factor proline and glutamine rich Homo sapiens 190-194 11161712-5 2001 PSF comprises an N-terminal proline- and glutamine-rich domain, two RRMs (RRM1 and RRM2), and a C-terminal region that contains two nuclear localization signals, both of which are required for complete nuclear localization. Proline 28-35 splicing factor proline and glutamine rich Homo sapiens 0-3