PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29981320-3 2018 Here, we examined whether co-administration of ergothioneine, a substrate/inhibitor of OCTN1, with l-OHP could prevent this peripheral neuropathy. Ergothioneine 47-60 solute carrier family 22 member 4 Rattus norvegicus 87-92 21606177-5 2011 HEK293 cells overexpressing rOctn1, rOctn2, human OCTN1, and human OCTN2 showed increased uptake and cytotoxicity of oxaliplatin compared with mock-transfected HEK293 controls; in addition, both uptake and cytotoxicity were inhibited by ergothioneine and L-carnitine. Ergothioneine 237-250 solute carrier family 22 member 4 Rattus norvegicus 28-34 21606177-6 2011 The uptake of ergothioneine mediated by OCTN1 and of L-carnitine mediated by OCTN2 was decreased during oxaliplatin exposure. Ergothioneine 14-27 solute carrier family 22 member 4 Rattus norvegicus 40-45 18670092-0 2008 Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Ergothioneine 31-44 solute carrier family 22 member 4 Rattus norvegicus 99-104 18670092-9 2008 The expression of rat Octn1 and a saturable and Na(+)-dependent transport of ergothioneine were observed in PC12 cells, suggesting that ergothioneine transport in this cell line may be mediated by rat Octn1. Ergothioneine 136-149 solute carrier family 22 member 4 Rattus norvegicus 201-206 18670092-10 2008 These findings suggested that rat Octn1 may act as a survival factor by taking up ergothioneine to suppress oxidative stress in this cell line. Ergothioneine 82-95 solute carrier family 22 member 4 Rattus norvegicus 34-39 18670092-11 2008 In conclusion, functional characteristics of ergothioneine transport by rat Octn1 is similar to that of human OCTN1 and it is suggested that rat Octn1 is important by transporting anti-oxidant ergothioneine in PC12 cells, though its role in vivo is to be investigated. Ergothioneine 45-58 solute carrier family 22 member 4 Rattus norvegicus 76-81 18670092-11 2008 In conclusion, functional characteristics of ergothioneine transport by rat Octn1 is similar to that of human OCTN1 and it is suggested that rat Octn1 is important by transporting anti-oxidant ergothioneine in PC12 cells, though its role in vivo is to be investigated. Ergothioneine 45-58 solute carrier family 22 member 4 Rattus norvegicus 145-150 18670092-11 2008 In conclusion, functional characteristics of ergothioneine transport by rat Octn1 is similar to that of human OCTN1 and it is suggested that rat Octn1 is important by transporting anti-oxidant ergothioneine in PC12 cells, though its role in vivo is to be investigated. Ergothioneine 193-206 solute carrier family 22 member 4 Rattus norvegicus 145-150 18670092-0 2008 Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). Ergothioneine 31-44 solute carrier family 22 member 4 Rattus norvegicus 106-113 18670092-6 2008 The present study, is to further investigate the role of rat Octn1 on transport of ergothioneine in rat Octn1 transfected cells and natively expressing cell line PC12 derived from rat adrenal pheochromocytoma. Ergothioneine 83-96 solute carrier family 22 member 4 Rattus norvegicus 61-66 18670092-6 2008 The present study, is to further investigate the role of rat Octn1 on transport of ergothioneine in rat Octn1 transfected cells and natively expressing cell line PC12 derived from rat adrenal pheochromocytoma. Ergothioneine 83-96 solute carrier family 22 member 4 Rattus norvegicus 104-109 18670092-7 2008 [(3)H]Ergothioneine uptake by rat Octn1 stably transfected HEK293 cells was saturable, sodium dependent with 1 : 1 stoichiometry of ergothioneine, and pH dependent. Ergothioneine 6-19 solute carrier family 22 member 4 Rattus norvegicus 34-39 18670092-7 2008 [(3)H]Ergothioneine uptake by rat Octn1 stably transfected HEK293 cells was saturable, sodium dependent with 1 : 1 stoichiometry of ergothioneine, and pH dependent. Ergothioneine 132-145 solute carrier family 22 member 4 Rattus norvegicus 34-39 18670092-9 2008 The expression of rat Octn1 and a saturable and Na(+)-dependent transport of ergothioneine were observed in PC12 cells, suggesting that ergothioneine transport in this cell line may be mediated by rat Octn1. Ergothioneine 77-90 solute carrier family 22 member 4 Rattus norvegicus 201-206 18670092-9 2008 The expression of rat Octn1 and a saturable and Na(+)-dependent transport of ergothioneine were observed in PC12 cells, suggesting that ergothioneine transport in this cell line may be mediated by rat Octn1. Ergothioneine 136-149 solute carrier family 22 member 4 Rattus norvegicus 22-27 35291466-0 2022 Effects of 1alpha,25-dihydroxyvitamin D3 on the pharmacokinetics and biodistribution of ergothioneine, an endogenous organic cation/carnitine transporter 1 substrate, in rats. Ergothioneine 88-101 solute carrier family 22 member 4 Rattus norvegicus 117-155 35291466-1 2022 Purpose: This study aimed to investigate the effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the expression levels of organic cation/carnitine transporter 1 (OCTN1) as well as the pharmacokinetics and biodistribution of ergothioneine, an OCTN1 substrate, in rats. Ergothioneine 230-243 solute carrier family 22 member 4 Rattus norvegicus 128-166 35291466-1 2022 Purpose: This study aimed to investigate the effects of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the expression levels of organic cation/carnitine transporter 1 (OCTN1) as well as the pharmacokinetics and biodistribution of ergothioneine, an OCTN1 substrate, in rats. Ergothioneine 230-243 solute carrier family 22 member 4 Rattus norvegicus 168-173 35291466-8 2022 Conclusion: This study showed the effects of 1,25(OH)2D3 on the expression and function of rOCTN1 by investigating the interaction between 1,25(OH)2D3 and ergothioneine. Ergothioneine 155-168 solute carrier family 22 member 4 Rattus norvegicus 91-97 30959054-5 2019 Na+-dependent uptake of ergothioneine (Octn1), carnitine (Octn2), and methyl-alpha-D-glucopyranoside (Sglt1/2) by rat kidney slices was observed, and the uptake was decreased by selective inhibitors. Ergothioneine 24-37 solute carrier family 22 member 4 Rattus norvegicus 39-44