PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23607596-0	2013	Identification of the ZAK-MKK4-JNK-TGFbeta signaling pathway as a molecular target for novel synthetic iminoquinone anticancer compound BA-TPQ.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	136-142	mitogen-activated protein kinase 8	Homo sapiens	31-34	
23607596-8	2013	In addition, BA-TPQ activates the ZAK-MKK4-JNK pathway in MCF7 cells, but not normal MCF10A cells, demonstrating its cancer-specific activities.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	13-19	mitogen-activated protein kinase 8	Homo sapiens	43-46	
23607596-9	2013	In conclusion, our results demonstrate that BA-TPQ activates the ZAK-MKK4-JNK-TGFbeta signaling cascade as a molecular target for its anticancer activity.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	44-50	mitogen-activated protein kinase 8	Homo sapiens	74-77	
23607596-3	2013	Herein, we report the molecular studies for BA-TPQ"s effects on JNK and its upstream and downstream signaling pathways.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	44-50	mitogen-activated protein kinase 8	Homo sapiens	64-67	
23607596-6	2013	It also up-regulates the TGFbeta2 mRNA level, which can be abolished by the JNK-specific inhibitor SP600125, but not TGFbeta pathway-specific inhibitor SD-208, indicating that both JNK and TGFbeta signaling pathways are activated by BA-TPQ and that the JNK pathway activation precedes TGFbeta activation.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	233-239	mitogen-activated protein kinase 8	Homo sapiens	181-184	
23607596-6	2013	It also up-regulates the TGFbeta2 mRNA level, which can be abolished by the JNK-specific inhibitor SP600125, but not TGFbeta pathway-specific inhibitor SD-208, indicating that both JNK and TGFbeta signaling pathways are activated by BA-TPQ and that the JNK pathway activation precedes TGFbeta activation.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	233-239	mitogen-activated protein kinase 8	Homo sapiens	181-184	
23607596-7	2013	The pro-apoptotic and anti-growth effects of BA-TPQ are significantly blocked by both the JNK and TGFbeta pathway inhibitors.	7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one	45-51	mitogen-activated protein kinase 8	Homo sapiens	90-93