PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4733835-1 1973 Inactivation of gamma-cystathionase, in vitro and in vivo, by propargylglycine. propargylglycine 62-78 cystathionine gamma-lyase Homo sapiens 16-35 24750035-6 2015 Androgen agonist mesterolone also increased H2S and induced vasodilatation; effects attenuated by the selective cystathionine-gamma lyase (CSE) inhibitor propargylglycine. propargylglycine 154-170 cystathionine gamma-lyase Homo sapiens 112-137 24750035-6 2015 Androgen agonist mesterolone also increased H2S and induced vasodilatation; effects attenuated by the selective cystathionine-gamma lyase (CSE) inhibitor propargylglycine. propargylglycine 154-170 cystathionine gamma-lyase Homo sapiens 139-142 16648-0 1977 Mechanism of inactivation of gamma-cystathionase by the acetylenic substrate analogue propargylglycine. propargylglycine 86-102 cystathionine gamma-lyase Homo sapiens 29-48 31594422-5 2020 CSE/CBS inhibitors propargylglycine, beta-cyano-L-alanine, and aminooxyacetic acid blocked brain H2S generation and cerebral vasodilation caused by SFN. propargylglycine 19-35 cystathionine gamma-lyase Homo sapiens 0-3 31089421-8 2019 The CSE inhibitor DL-propargylglycine (PAG) completely abrogated the effects of RU486 on blocking the suppressive effects of DEX. propargylglycine 18-37 cystathionine gamma-lyase Homo sapiens 4-7 31160338-3 2019 CSE is inhibited by propargylglycine (PPG), a widely used mechanism-based inhibitor. propargylglycine 20-36 cystathionine gamma-lyase Homo sapiens 0-3 31160338-3 2019 CSE is inhibited by propargylglycine (PPG), a widely used mechanism-based inhibitor. propargylglycine 38-41 cystathionine gamma-lyase Homo sapiens 0-3 31160338-10 2019 In summary, our study reveals a previously unknown confounding effect of PPG, widely used to inhibit CSE-dependent H2S synthesis, and reports on an alternative inhibitor, CPC, which could be used as a scaffold to develop more potent H2S biogenesis inhibitors. propargylglycine 73-76 cystathionine gamma-lyase Homo sapiens 101-104 31089421-8 2019 The CSE inhibitor DL-propargylglycine (PAG) completely abrogated the effects of RU486 on blocking the suppressive effects of DEX. propargylglycine 39-42 cystathionine gamma-lyase Homo sapiens 4-7 28552745-7 2017 The CSE inhibitor dl-propargylglycine (PPG) and aspartate (limits MPST) had no effect alone, but when applied together with AOAA the hypoxic relaxation response was further reduced. propargylglycine 18-37 cystathionine gamma-lyase Homo sapiens 4-7 28552745-7 2017 The CSE inhibitor dl-propargylglycine (PPG) and aspartate (limits MPST) had no effect alone, but when applied together with AOAA the hypoxic relaxation response was further reduced. propargylglycine 39-42 cystathionine gamma-lyase Homo sapiens 4-7 27440715-9 2016 Pretreatment with the cystathionine-gamma-lyase inhibitor d/l-propargylglycine (PAG) decreased hypoxic inhibition of sodium transport by H441 monolayers, whereas inhibition of cystathionine-beta-synthase (with aminooxy-acetic acid; AOAA) or 3-mercaptopyruvate sulfurtransferase (with aspartate) had no effect. propargylglycine 60-78 cystathionine gamma-lyase Homo sapiens 22-47 27061011-5 2016 In turn, the HCy effect was inhibited using DL-propargylglycine, a specific inhibitor of the hydrogen sulphide (H2 S)-synthesizing enzyme cystathionine-gamma-lyase involved in HCy catabolism. propargylglycine 44-63 cystathionine gamma-lyase Homo sapiens 138-163 25822632-5 2015 Furthermore expression of these genes were reduced by aminooxyacetic acid (AOAA, CBS inhibitor), DL-propargylglycine (PAG, CSE inhibitor) as well as by CSE small interference RNA (siCSE) and siCBS. propargylglycine 97-116 cystathionine gamma-lyase Homo sapiens 123-126 27150157-5 2016 CSE inhibitors, DL-propargylglycine (PPG) and beta-cyano-L-alanine (BCA), significantly suppressed the proliferation of AGS cells in a concentration-dependent manner. propargylglycine 16-35 cystathionine gamma-lyase Homo sapiens 0-3 27150157-5 2016 CSE inhibitors, DL-propargylglycine (PPG) and beta-cyano-L-alanine (BCA), significantly suppressed the proliferation of AGS cells in a concentration-dependent manner. propargylglycine 37-40 cystathionine gamma-lyase Homo sapiens 0-3 27313828-8 2016 Moreover, the antioxidative effect of SPRC was abolished by CSE inhibitor DL-propargylglycine (PAG) and HO-1 siRNA. propargylglycine 74-93 cystathionine gamma-lyase Homo sapiens 60-63 27313828-8 2016 Moreover, the antioxidative effect of SPRC was abolished by CSE inhibitor DL-propargylglycine (PAG) and HO-1 siRNA. propargylglycine 95-98 cystathionine gamma-lyase Homo sapiens 60-63 26192364-6 2015 Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions. propargylglycine 148-166 cystathionine gamma-lyase Homo sapiens 79-104 26192364-6 2015 Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions. propargylglycine 148-166 cystathionine gamma-lyase Homo sapiens 106-109 26192364-6 2015 Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions. propargylglycine 168-171 cystathionine gamma-lyase Homo sapiens 79-104 26192364-6 2015 Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions. propargylglycine 168-171 cystathionine gamma-lyase Homo sapiens 106-109 24508802-4 2014 dl-Propargylglycine (PPG), a CSE inhibitor, significantly decreased T-currents in Cav3.2-HEK293 cells, but not in NG108-15 cells. propargylglycine 0-19 cystathionine gamma-lyase Homo sapiens 29-32 24951966-10 2014 Blockade of CSE with its inhibitor dl-propargylglycine (PAG) or siRNA markedly reduced the H2S level in fluvastatin-stimulated macrophages. propargylglycine 35-54 cystathionine gamma-lyase Homo sapiens 12-15 24951966-10 2014 Blockade of CSE with its inhibitor dl-propargylglycine (PAG) or siRNA markedly reduced the H2S level in fluvastatin-stimulated macrophages. propargylglycine 56-59 cystathionine gamma-lyase Homo sapiens 12-15 24951966-13 2014 Last, we showed that fluvastatin reduced the mRNA levels of pro-inflammatory molecules such as IL-1beta and MCP-1 in LPS-treated macrophages, which were completely reversed by CSE inhibitor PAG. propargylglycine 190-193 cystathionine gamma-lyase Homo sapiens 176-179 24756435-12 2014 Furthermore, the inhibition of endogenous CSE by DL-propargylglycine increased EMT in the MCF-7 cells treated with NaHS and TGF-beta1. propargylglycine 49-68 cystathionine gamma-lyase Homo sapiens 42-45 24707893-3 2014 We found that inhibiting CSE activity with PAG (propargylglycine) or silencing CSE expression using an siRNA approach resulted in a greater reduction in cell viability under exposure to the oxidizing agent hydrogen peroxide (H2O2). propargylglycine 43-46 cystathionine gamma-lyase Homo sapiens 25-28 24707893-3 2014 We found that inhibiting CSE activity with PAG (propargylglycine) or silencing CSE expression using an siRNA approach resulted in a greater reduction in cell viability under exposure to the oxidizing agent hydrogen peroxide (H2O2). propargylglycine 48-64 cystathionine gamma-lyase Homo sapiens 25-28 25543188-6 2015 In addition, Na2S also enhanced H2S level and CSE expression associated with upregulation of SIRT6 expression and activity in OGD/R-stimulated brain endothelial cells, whereas CSE inhibitor DL-propargylglycine further deteriorated the decrease of SIRT6 expression and activity as well as the reduction of H2S level and CSE expression caused by OGD/R. propargylglycine 190-209 cystathionine gamma-lyase Homo sapiens 176-179 25543188-6 2015 In addition, Na2S also enhanced H2S level and CSE expression associated with upregulation of SIRT6 expression and activity in OGD/R-stimulated brain endothelial cells, whereas CSE inhibitor DL-propargylglycine further deteriorated the decrease of SIRT6 expression and activity as well as the reduction of H2S level and CSE expression caused by OGD/R. propargylglycine 190-209 cystathionine gamma-lyase Homo sapiens 176-179 25113159-8 2014 However, VEGF-induced Ca(2+) signals were suppressed by dl-propargylglycine (PAG), which blocks the H2S-producing enzyme, cystathionine gamma-lyase. propargylglycine 56-75 cystathionine gamma-lyase Homo sapiens 122-147 25113159-8 2014 However, VEGF-induced Ca(2+) signals were suppressed by dl-propargylglycine (PAG), which blocks the H2S-producing enzyme, cystathionine gamma-lyase. propargylglycine 77-80 cystathionine gamma-lyase Homo sapiens 122-147 24508802-4 2014 dl-Propargylglycine (PPG), a CSE inhibitor, significantly decreased T-currents in Cav3.2-HEK293 cells, but not in NG108-15 cells. propargylglycine 21-24 cystathionine gamma-lyase Homo sapiens 29-32 23733596-5 2013 The effect of LC on PIP3 was prevented by propargylglycine, an inhibitor of cystathionine-gamma-lyase (CSE) that catalyzes H2S formation from LC. propargylglycine 42-58 cystathionine gamma-lyase Homo sapiens 76-101 23733596-5 2013 The effect of LC on PIP3 was prevented by propargylglycine, an inhibitor of cystathionine-gamma-lyase (CSE) that catalyzes H2S formation from LC. propargylglycine 42-58 cystathionine gamma-lyase Homo sapiens 103-106 20546998-5 2010 administration of dl-propargylglycine (PPG) and beta-cyanoalanine, irreversible and reversible CSE inhibitors, respectively, strongly suppressed the neuropathic hyperalgesia/allodynia. propargylglycine 18-37 cystathionine gamma-lyase Homo sapiens 95-98 23704251-5 2013 Inhibition of CSE activity by DL-propargylglycine reduced placental growth factorproduction from first-trimester (8-12 weeks gestation) human placental explants and inhibited trophoblast invasion in vitro. propargylglycine 30-49 cystathionine gamma-lyase Homo sapiens 14-17 23393548-9 2013 Interestingly, in the current model, D, L-propargylglycine (PAG), a selective inhibitor of cystathionine gamma-lyase (CSE), abolished the protective effects of H2S donors. propargylglycine 60-63 cystathionine gamma-lyase Homo sapiens 91-116 23393548-9 2013 Interestingly, in the current model, D, L-propargylglycine (PAG), a selective inhibitor of cystathionine gamma-lyase (CSE), abolished the protective effects of H2S donors. propargylglycine 60-63 cystathionine gamma-lyase Homo sapiens 118-121 22034194-8 2012 Blockage of SP1 binding by mithramycin or inhibition of CSE activity by DL-propargylglycine did not change miR-21 expression. propargylglycine 72-91 cystathionine gamma-lyase Homo sapiens 56-59 22340158-9 2011 An inhibitor of cystathionine gamma-lyase (CSE), DL-propargylglycine (PPG, 200 micromol/L), increased APA, V(max), VDD and RPF, and prolonged APD(90). propargylglycine 49-68 cystathionine gamma-lyase Homo sapiens 16-41 21952317-4 2011 Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced. propargylglycine 63-82 cystathionine gamma-lyase Homo sapiens 163-188 21952317-4 2011 Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced. propargylglycine 63-82 cystathionine gamma-lyase Homo sapiens 190-193 21952317-4 2011 Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced. propargylglycine 84-87 cystathionine gamma-lyase Homo sapiens 163-188 21952317-4 2011 Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced. propargylglycine 84-87 cystathionine gamma-lyase Homo sapiens 190-193 23074218-5 2012 The effect of 1,25(OH)(2)D(3) on GLUT4 translocation, glucose utilization, and H(2)S formation was prevented by propargylglycine, an inhibitor of CSE that catalyzes H(2)S formation. propargylglycine 112-128 cystathionine gamma-lyase Homo sapiens 146-149 23074218-8 2012 1,25(OH)(2)D(3) supplementation also inhibited monocyte chemoattractant protein-1 and stimulated adiponectin secretion in HG-treated adipocytes, and this positive effect was prevented in propargylglycine-treated or CSE-knockdown adipocytes. propargylglycine 187-203 cystathionine gamma-lyase Homo sapiens 215-218 19246614-4 2009 This H(2)S production was completely abolished by inhibition of both cystathionine beta-synthetase (CBS) and cystathionine gamma-lyase (CGL), two major enzymes for the production of H(2)S, using amino-oxyacetic acid (AOAA), an inhibitor of CBS, and propargylglycine (PPG), an inhibitor of CGL. propargylglycine 249-265 cystathionine gamma-lyase Homo sapiens 109-134 20060865-5 2010 Co-incubation of cells with gliotoxin and propargylglycine reduced glutathione to 39% of control at 24 h and to 20% at 48 h. Expression of cystathionine-gamma-lyase, the rate-limiting enzyme of the transsulfuration pathway, was significantly increased following incubation of the cells with gliotoxins. propargylglycine 42-58 cystathionine gamma-lyase Homo sapiens 139-164 16230075-7 2005 Glibenclamide, a K(ATP) channel inhibitor, and DL-propargylglycine, a CSE inhibitor, exacerbated, whereas pinacidil, a K(ATP) opener, attenuated gastric injury caused by ASA. propargylglycine 47-66 cystathionine gamma-lyase Homo sapiens 70-73 19255435-7 2009 Electrical field stimulation of human penile tissue, under resting conditions, causes an increase in tension that is significantly potentiated by either propargylglycine (PAG; CSE inhibitor) or AOAA. propargylglycine 153-169 cystathionine gamma-lyase Homo sapiens 176-179 19255435-7 2009 Electrical field stimulation of human penile tissue, under resting conditions, causes an increase in tension that is significantly potentiated by either propargylglycine (PAG; CSE inhibitor) or AOAA. propargylglycine 171-174 cystathionine gamma-lyase Homo sapiens 176-179 18679378-3 2008 Administration of the irreversible cystathionine gamma-lyase (CSE) inhibitor, dL-propargylglycine, prevented the recovery of renal function after 45 min ischemia and 72 h reperfusion. propargylglycine 78-97 cystathionine gamma-lyase Homo sapiens 35-60 18679378-3 2008 Administration of the irreversible cystathionine gamma-lyase (CSE) inhibitor, dL-propargylglycine, prevented the recovery of renal function after 45 min ischemia and 72 h reperfusion. propargylglycine 78-97 cystathionine gamma-lyase Homo sapiens 62-65 18029544-6 2008 Artery homogenates converted cysteine to H(2)S, and the H(2)S production was inhibited by dl-propargylglycine, an inhibitor of CSE. propargylglycine 90-109 cystathionine gamma-lyase Homo sapiens 127-130 19019829-3 2009 Inhibition of CSE by DL-propargylglycine (PAG) has been shown to alleviate disease symptoms. propargylglycine 21-40 cystathionine gamma-lyase Homo sapiens 14-17 19019829-3 2009 Inhibition of CSE by DL-propargylglycine (PAG) has been shown to alleviate disease symptoms. propargylglycine 42-45 cystathionine gamma-lyase Homo sapiens 14-17 19019829-4 2009 Here we report crystal structures of human CSE (hCSE), in apo form, and in complex with PLP and PLP.PAG. propargylglycine 100-103 cystathionine gamma-lyase Homo sapiens 43-46 15047144-10 2004 Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma H2S content and worsened HPH. propargylglycine 29-45 cystathionine gamma-lyase Homo sapiens 69-94 15047144-10 2004 Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma H2S content and worsened HPH. propargylglycine 29-45 cystathionine gamma-lyase Homo sapiens 96-99 15047144-10 2004 Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma H2S content and worsened HPH. propargylglycine 47-50 cystathionine gamma-lyase Homo sapiens 69-94 15047144-10 2004 Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma H2S content and worsened HPH. propargylglycine 47-50 cystathionine gamma-lyase Homo sapiens 96-99 10212249-8 1999 Propargylglycine inactivated human cystathionine gamma-lyase much more strongly than trifluoroalanine, in agreement with the enzyme"s preference for C-gamma-S bonds. propargylglycine 0-16 cystathionine gamma-lyase Homo sapiens 35-60