PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21257919-4	2011	Real-time qRT-PCR analysis showed that DHT induced androgen receptor (AR), cyclin A, cyclin D1, and vascular endothelial growth factor (VEGF) gene expression in a dose- and time-dependent manner.	Dihydrotestosterone	39-42	cyclin D1	Homo sapiens	85-94	
22535971-8	2012	DHT also inhibited basal (P < 0.05) and E(2)-induced expression of cyclin-D1 mRNA (P < 0.05).	Dihydrotestosterone	0-3	cyclin D1	Homo sapiens	70-79	
18275596-8	2008	DHT added together with E2 to the cell culture medium decreased the recruitment of CAMA-1 cells in the S phase and the expression of ESR1 and CCND1 by comparison with cells treated with E2 alone.	Dihydrotestosterone	0-3	cyclin D1	Homo sapiens	142-147	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	109-118	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	160-169	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	55-82	cyclin D1	Homo sapiens	211-216	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	109-118	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	160-169	
20421209-2	2010	Here we demonstrate that the non-aromatizable androgen 5-alpha-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expression, as evidenced by reduction of cyclin D1 mRNA and protein levels, and decrease of CCND1-promoter activity, in MCF-7 cells.	Dihydrotestosterone	84-87	cyclin D1	Homo sapiens	211-216	
20421209-3	2010	The DHT-dependent inhibition of CCND1 gene activity requires the involvement and the integrity of the androgen receptor (AR) DNA-binding domain.	Dihydrotestosterone	4-7	cyclin D1	Homo sapiens	32-37	
18673534-9	2008	However, overexpression of AR enhanced the DHT-stimulated expression of MAK, BRCA1, AIB1 and CBP and reduced the level of expression of beta-catenin, cyclinD1 and gelsolin.	Dihydrotestosterone	43-46	cyclin D1	Homo sapiens	150-158	
17879940-6	2007	The inhibition of cell proliferation was associated with a blockade of DHT-induced cyclin A and cyclin D1 expression by alphaE2 and betaE2.	Dihydrotestosterone	71-74	cyclin D1	Homo sapiens	96-105	
17879940-8	2007	CONCLUSION: alphaE2 is an effective agent for inhibition of DHT-induced PSA, cyclin A, cyclin D1 gene expression, and cell proliferation in LAPC-4 cells, and tumor growth in LAPC-4 xenograft mice.	Dihydrotestosterone	60-63	cyclin D1	Homo sapiens	87-96	
25040852-6	2015	Stimulation of AR by dihydrotestosterone in OSCC cells caused an increase in cyclin D1 expression and promoted cell growth, whereas treatment with bicalutamide led to decreased cyclin D1 expression and inhibited cell growth.	Dihydrotestosterone	21-40	cyclin D1	Homo sapiens	77-86	
16885382-2	2006	Androgen [5alpha-dihydrotestosterone (DHT)] stimulation of LNCaP prostate cancer cells, which have constitutive phosphatidylinositol 3-kinase (PI3K)/Akt pathway activation due to PTEN loss, caused increased expression of cyclin D1, D2, and D3 proteins, retinoblastoma protein hyperphosphorylation, and cell cycle progression.	Dihydrotestosterone	10-36	cyclin D1	Homo sapiens	221-230	
15322241-4	2004	p21(WAF1/CIP1), which is involved in the assembly of cyclin D1/cyclin-dependent kinase-4 complexes, was increased by DHT or TCDD when each compound was administered singly but was reduced to background levels in cells simultaneously treated with DHT and TCDD.	Dihydrotestosterone	117-120	cyclin D1	Homo sapiens	53-88	
26938985-11	2016	Moreover, DHT-dependent activation of AR involves regulation in the cell cycle related genes, including p73, p21 and Cyclin D1.	Dihydrotestosterone	10-13	cyclin D1	Homo sapiens	117-126