PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16317058-8 2006 In addition, DHT inhibited mRNA expression of IL-6, MCP-1, CD40, TLR4, PAI-1, and Cox-2 and the release of cytokines and chemokines such as GRO, granulocyte-macrophage colony-stimulating factor, and TNF. Dihydrotestosterone 13-16 C-C motif chemokine ligand 2 Homo sapiens 52-57 32755990-11 2020 DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF. Dihydrotestosterone 0-3 C-C motif chemokine ligand 2 Homo sapiens 115-119 32755990-11 2020 DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF. Dihydrotestosterone 0-3 C-C motif chemokine ligand 2 Homo sapiens 158-162 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 113-132 C-C motif chemokine ligand 2 Homo sapiens 57-62 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 336-339 C-C motif chemokine ligand 2 Homo sapiens 57-62 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 134-137 C-C motif chemokine ligand 2 Homo sapiens 57-62 23585426-5 2013 Dihydrotestosterone was found to induce a time-dependent (0-72 hours) and concentration-dependent (0-1 nmol/L) increase in CCL2 mRNA levels in androgen-responsive human prostate cancer cells (LNCaP). Dihydrotestosterone 0-19 C-C motif chemokine ligand 2 Homo sapiens 123-127 23585426-7 2013 The effect of dihydrotestosterone was mediated through an androgen receptor (AR)-dependent pathway as small inhibitor RNA against AR negated the induction of CCL2. Dihydrotestosterone 14-33 C-C motif chemokine ligand 2 Homo sapiens 158-162 23585426-8 2013 Although dihydrotestosterone also induced TWIST1 mRNA, an epithelial-mesenchymal transition-related factor, and purported inducer of CCL2, blocking its expression with small inhibitor RNA did not inhibit dihydrotestosterone induction of CCL2 mRNA. Dihydrotestosterone 9-28 C-C motif chemokine ligand 2 Homo sapiens 133-137 23585426-10 2013 Both I3C and DIM inhibited promotional effects of dihydrotestosterone on CCL2 and migration. Dihydrotestosterone 50-69 C-C motif chemokine ligand 2 Homo sapiens 73-77