PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16542735-2 2006 The Val108/158Met polymorphism of the COMT gene influences its enzymatic activity and may result in altered concentrations of monoamine metabolites and different clinical responses of patients to pharmacological treatments. monoamine 126-135 catechol-O-methyltransferase Homo sapiens 38-42 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. monoamine 115-124 catechol-O-methyltransferase Homo sapiens 11-39 18802928-2 2009 The enzyme catechol O-methyltransferase (COMT), which degrades dopamine and other catecholamines, is important for monoamine signaling in this brain-region, but genetic studies of the functional Val158Met (rs4680) polymorphism in ADHD have been inconsistent. monoamine 115-124 catechol-O-methyltransferase Homo sapiens 41-45 18997477-11 2008 Nevertheless, COMT polymorphisms may influence some of the characteristics of the patients by their effect on monoamine metabolism. monoamine 110-119 catechol-O-methyltransferase Homo sapiens 14-18 12756858-8 2002 However, in an Israeli study, an association was found between susceptibility for AN and the COMT gene, which is involved in monoamine metabolism. monoamine 125-134 catechol-O-methyltransferase Homo sapiens 93-97 15292670-2 2004 It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific personality traits. monoamine 144-153 catechol-O-methyltransferase Homo sapiens 34-62 15292670-2 2004 It has been demonstrated that the catechol-O-methyltransferase (COMT) Val158Met genetic polymorphism, a functional polymorphism that may affect monoamine metabolism, is possibly associated with specific personality traits. monoamine 144-153 catechol-O-methyltransferase Homo sapiens 64-68 15340358-1 2005 Catechol-O-methyltransferase (COMT) has been implicated in schizophrenia by its function through its roles in monoamine neurotransmitter metabolism and its impact on prefrontal cognition, and also by its position through linkage scans and a strong cytogenetic association. monoamine 110-119 catechol-O-methyltransferase Homo sapiens 0-28 15340358-1 2005 Catechol-O-methyltransferase (COMT) has been implicated in schizophrenia by its function through its roles in monoamine neurotransmitter metabolism and its impact on prefrontal cognition, and also by its position through linkage scans and a strong cytogenetic association. monoamine 110-119 catechol-O-methyltransferase Homo sapiens 30-34 25073638-4 2014 METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. monoamine 82-91 catechol-O-methyltransferase Homo sapiens 231-259 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. monoamine 240-249 catechol-O-methyltransferase Homo sapiens 16-44 9326274-1 1997 To determine if catechol-O-methyltransferase (COMT) metabolizes catecholamines within cell lines used for heterologous expression of plasmalemmal transporters and alters the measured characteristics of 3H-substrate transport, the uptake of monoamine transporter substrates was assessed in three cell lines (C6 glioma, L-M fibroblast, and HEK293 cells) that had been transfected with the recombinant human transporters. monoamine 240-249 catechol-O-methyltransferase Homo sapiens 46-50 7001505-3 1980 The hypothesis of monoamine alterations associated with the affective illnesses has led to studies of genetics of enzymes of monoamine metabolism as observed in peripheral blood, erythrocyte catechol-O-methyl-transferase (COMT), platelet monoamine oxidase (MAO), and plasma dopamine-beta-hydroxylase (DBH). monoamine 125-134 catechol-O-methyltransferase Homo sapiens 191-220 9477008-0 1997 Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers. monoamine 93-102 catechol-O-methyltransferase Homo sapiens 27-55 25073638-4 2014 METHODS: We have searched for association between 119 SNPs in genes implicated in monoaminergic pathways [tryptophan hydroxylase 1 (TPH1), TPH2, tyrosine hydroxylase (TH), DOPA decarboxylase (DDC), dopamine beta-hydroxylase (DBH), catechol-O-methyltransferase (COMT), monoamine oxidase A (MAOA) and MAOB] and monoamine metabolite concentrations in CSF in 74 patients with psychotic disorder. monoamine 82-91 catechol-O-methyltransferase Homo sapiens 261-265 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. monoamine 145-154 catechol-O-methyltransferase Homo sapiens 70-74 24508446-2 2014 It is thought that PD is related to neurotransmitter pathways, such as brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT), both of which are involved in the regulation of the monoamine mechanism. monoamine 205-214 catechol-O-methyltransferase Homo sapiens 116-144 24508446-2 2014 It is thought that PD is related to neurotransmitter pathways, such as brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT), both of which are involved in the regulation of the monoamine mechanism. monoamine 205-214 catechol-O-methyltransferase Homo sapiens 146-150 23026378-2 2013 Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. monoamine 175-184 catechol-O-methyltransferase Homo sapiens 126-154 23026378-2 2013 Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. monoamine 175-184 catechol-O-methyltransferase Homo sapiens 156-160 23026378-2 2013 Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. monoamine 263-272 catechol-O-methyltransferase Homo sapiens 126-154 23026378-2 2013 Monoaminergic dysfunction has been implicated in the pathogenesis of BP, it may be important to investigate genes such as the catechol-O-methyltransferase (COMT), involved in monoamine metabolism and brain-derived neurotrophic factor (BDNF) genes, modulating the monoamine system. monoamine 263-272 catechol-O-methyltransferase Homo sapiens 156-160