PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26751814-6 2016 Intranasally administered OBD was effective in partially reducing paraoxon-induced acetylcholinesterase inhibition in the brain and substantially reduced seizure severity and duration. Paraoxon 66-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 27682399-4 2016 In the presence of paraoxon, the activity of AChE is inhibited, and thus preventing the generation of thiocholine, causing fewer NC-dots to be replaced. Paraoxon 19-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 25190468-0 2014 Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties. Paraoxon 72-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-50 26427931-2 2016 The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 26427931-6 2016 Bisoximes obidoxime and K108 resulted as the best reactivators for paraoxon-, methylparaoxon- and DFP-inhibited AChE. Paraoxon 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-116 25190468-4 2014 Further the tested oximes were screened through in vitro reactivation kinetics against paraoxon-inhibited AChE. Paraoxon 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24704618-2 2014 These novel molecules display in vitro reactivation potencies towards VX-, tabun- and paraoxon-inhibited human AChE that are superior to those of the mono- and bis-pyridinium aldoximes currently used against nerve agent and pesticide poisoning. Paraoxon 86-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 24832999-2 2014 Here, we report on a versatile strategy to synthesize functionalized graphene oxide nanomaterials with abundant affinity groups that can capture histidine (His)-tagged acetylcholinesterase (AChE) for the fabrication of paraoxon biosensors. Paraoxon 219-227 acetylcholinesterase (Cartwright blood group) Homo sapiens 190-194 23631528-1 2013 Amphiphilic peptides were designed to fold into a beta-sheet monolayer structure while presenting the catalytic triad residues of the enzyme, acetylcholinesterase (Glu, His, and Ser), to a solution containing the organophosphate, paraoxon. Paraoxon 230-238 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-162 24599312-3 2014 Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE. Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 24225492-7 2014 Furthermore, this novel and highly sensitive sensing system allows the detection of 80 pM of the AChE inhibitor paraoxon and 100 nM of galanthamine. Paraoxon 112-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 97-101 23631528-6 2013 Circular dichroism revealed that the peptide most sensitive to interactions with paraoxon was that with the triad residues in the order Glu, Ser, and His, which appears to be appropriate for supporting a catalytic mechanism similar to that in the acetylcholinesterase enzyme. Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 247-267 22975155-1 2013 A library of more than 200 novel uncharged oxime reactivators was used to select and refine lead reactivators of human acetylcholinesterase (hAChE) covalently conjugated with sarin, cyclosarin, VX, paraoxon and tabun. Paraoxon 198-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-146 21787676-4 2011 Further, the paraoxon-induced modulatory effects were comparable despite different cell types, including over-expression of N-terminus acetylcholinesterase (N-AChE) protein, a marker of apoptosis, down-regulations of mRNA encoding M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs), and induction in expression of c-Fos gene, an indication of certain mAChR subtype(s) activation. Paraoxon 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-155 21600321-0 2011 An acetylcholinesterase biosensor for determination of low concentrations of Paraoxon and Dichlorvos. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 3-23 21600321-1 2011 The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed. Paraoxon 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 21600321-1 2011 The characterization of an economic and ease-to-use carbon paste acetylcholinesterase (AChE) based biosensor to determine the concentration of pesticides Paraoxon and Dichlorvos is discussed. Paraoxon 154-162 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 21600321-4 2011 Because Paraoxon and Dichlorvos inhibit the AChE reaction, the decrease of the current intensity, at fixed ATCl concentration, is a measure of their concentration. Paraoxon 8-16 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 21930118-4 2011 Now, an in vitro study was performed to determine the reactivation kinetics of MINA with tabun-, sarin-, cyclosarin-, VX- and paraoxon-inhibited human AChE. Paraoxon 126-134 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 21889639-4 2011 The method was demonstrated for the detection of paraoxon as reference AChE inhibitor. Paraoxon 49-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 21376964-3 2011 Subsequently, AChE catalytic activity was inhibited with the addition of paraoxon, which caused TCh decreased, leading to a significant decrease of the blue fluorescent compound. Paraoxon 73-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Paraoxon 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 21215642-5 2011 These compounds were synthesized, evaluated in vitro on human AChE (hAChE) inhibited by tabun, paraoxon, methylparaoxon and DFP and then compared to commercial hAChE reactivators (pralidoxime, HI-6, trimedoxime, obidoxime, methoxime) or previously prepared compounds (K027, K203). Paraoxon 95-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 68-73 22343626-2 2012 Starting with the initial lead oxime RS41A identified in our earlier study and extending to the azepine analog RS194B, reactivation rates for OP-hAChE conjugates formed by sarin, cyclosarin, VX, paraoxon, and tabun are enhanced severalfold in vitro. Paraoxon 195-203 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-150 21761139-0 2012 Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. Paraoxon 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 11-31 20888407-5 2011 Activities of brain and SH-SY5Y AChE with OP compounds alone ranged from 55-83% lower than non-treated controls after paraoxon and from 60-92% lower than non-treated controls after DFP. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-36 21787676-4 2011 Further, the paraoxon-induced modulatory effects were comparable despite different cell types, including over-expression of N-terminus acetylcholinesterase (N-AChE) protein, a marker of apoptosis, down-regulations of mRNA encoding M1, M2, and M3 muscarinic acetylcholine receptors (mAChRs), and induction in expression of c-Fos gene, an indication of certain mAChR subtype(s) activation. Paraoxon 13-21 acetylcholinesterase (Cartwright blood group) Homo sapiens 157-163 21787676-5 2011 Furthermore, the non-selective cholinergic antagonist atropine partially attenuated the paraoxon-induced N-AChE and c-Fos activations in both types of cells. Paraoxon 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-111 20032868-0 2009 Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Paraoxon 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 20510904-3 2010 The inhibition of AChE activity at varying insecticide concentrations was detected with low detection limits of 10 ppb (36 nM) for paraoxon and 8 ppb (18 nM) for carbofuran. Paraoxon 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 21673941-1 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos). Paraoxon 290-298 acetylcholinesterase (Cartwright blood group) Homo sapiens 177-197 21673941-4 2011 According to our results, the best broad-spectrum AChE reactivators were trimedoxime and obidoxime in the case of paraoxon, leptophos-oxon, and methamidophos-inhibited AChE. Paraoxon 114-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 20144593-4 2010 However, tested oximes were not efficient in reactivation of either tabun or paraoxon inhibited AChE. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-100 20113735-3 2010 The biosensor detected paraoxon in the range 0.035-1.38 ppm and can be used to detect other AChE inhibiting organophosphate pesticides. Paraoxon 23-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 92-96 20032868-4 2009 As it resulted, none of the prepared compounds surpassed obidoxime, which is considered to be the most potent compound if used for reactivation of AChE inhibited by paraoxon. Paraoxon 165-173 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 19665386-3 2009 Among the compounds explored in this study, the mono-fluorinated carbamoyl aldoxime 4b was the most potent reactivator for paraoxon-inhibited red blood cell (RBC) AChE. Paraoxon 123-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 163-167 19640713-0 2009 New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Paraoxon 87-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 141-161 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Paraoxon 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 19928287-5 2009 Inhibition of AChE by paraoxon is determined by the decrease in catalytic activity of AChE. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 19928287-5 2009 Inhibition of AChE by paraoxon is determined by the decrease in catalytic activity of AChE. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-90 19492815-6 2009 AChE inhibitors, including paraoxon and aflatoxin B1, were detected successfully using this sensor by measuring the residual activity of AChE on paper, using Ellman"s colorimetric assay, with capture of the 5-thio-2-nitrobenzoate (TNB(-)) product on the PVAm layer. Paraoxon 27-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 18341256-4 2008 According to the results obtained, one reactivator seems to be promising against tabun-inhibited AChE and two reactivators against paraoxon-inhibited AChE. Paraoxon 131-139 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-154 18617161-0 2008 Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. Paraoxon 106-114 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 19586353-0 2009 In vitro oxime-assisted reactivation of paraoxon-inhibited human acetylcholinesterase and butyrylcholinesterase. Paraoxon 40-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-111 19586353-3 2009 METHODS: Eighteen structurally different oxime reactivators were tested for their in vitro ability to reactivate paraoxon-inhibited human erythrocyte acetylcholinesterase and human plasma butyrylcholinesterase to find out structure-activity relationship within this set of compounds. Paraoxon 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 18615283-0 2008 Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation. Paraoxon 63-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-102 18615283-1 2008 Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE) using three reactivators for reactivation purposes: obidoxime, pralidoxime, and HI-6. Paraoxon 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 18615283-1 2008 Photometric microplate assay was performed for testing of paraoxon-inhibited acetylcholinesterase (AChE) using three reactivators for reactivation purposes: obidoxime, pralidoxime, and HI-6. Paraoxon 58-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18855408-3 2008 A pair of antibodies was used to achieve the specific recognition of OP-AChE that was prepared with paraoxon as an OP model agent. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 18804659-8 2008 The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-147 18617161-7 2008 Results demonstrated that obidoxime (96.8%) and trimedoxime (86%) only reached sufficient reactivation efficacy in case of paraoxon-inhibited AChE. Paraoxon 123-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 18617161-11 2008 From the data obtained, it is clear that only two from currently available oximes (obidoxime and trimedoxime) are good reactivators of paraoxon-inhibited AChE. Paraoxon 135-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-158 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Paraoxon 311-319 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 17097792-6 2007 In previous experiments with carbamate pre-treatment and paraoxon challenge we noticed an increased residual activity of erythrocyte acetylcholinesterase compared to non-pre-treatment. Paraoxon 57-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-153 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Paraoxon 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 17764957-0 2007 Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase. Paraoxon 117-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 17764957-3 2007 The known reactivators (pralidoxime, HI-6, obidoxime, K075, K203) and the new compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE. Paraoxon 134-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 153-157 17370251-5 2007 In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination. Paraoxon 130-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 79-83 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-2 2007 A relevant example is that of the stress-induced, normally rare, and naturally unstable "read-through" human acetylcholinesterase variant, AChE-R. AChE-R shares its active site with the synaptic AChE-S variant, which is the target of poisonous organophosphate anticholinesterase insecticides such as the parathion metabolite paraoxon. Paraoxon 325-333 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 17475919-5 2007 AChE-R(ER) purified to homogeneity showed indistinguishable biochemical properties, with IC50 = 10(-7) M for the organophosphate paraoxon, similar to mammalian cell culture-derived AChE. Paraoxon 129-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 17847708-2 2007 Their potency to reactivate AChE inhibited by the nerve agent tabun and the insecticide paraoxon together with nine symmetrical xylene-bridged compounds, was tested in vitro. Paraoxon 88-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 17847708-3 2007 Seven compounds were promising against paraoxon-inhibited AChE. Paraoxon 39-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-62 17383875-2 2007 Their ability to reactivate AChE, which had been previously inhibited by nerve agent tabun or pesticide paraoxon, was tested in vitro and compared to pralidoxime, HI-6, obidoxime, and K075. Paraoxon 104-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 17383875-4 2007 Notably, the oxime group in position four substantially increased the ability of the novel compounds to reactivate paraoxon-inhibited AChE. Paraoxon 115-123 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. Paraoxon 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 17467020-7 2007 Collectively, these results demonstrate that the interactions of chlorpyrifos oxon and methyl paraoxon with acetylcholinesterase cannot be described by simple Michaelis-Menten kinetics but instead support the hypothesis that these oxons bind to a secondary site on acetylcholinesterase, leading to activation/inhibition of the catalytic site, depending on the nature of the substrate and inhibitor. Paraoxon 94-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 265-285 16766477-5 2006 The anti-AChE activity of paraoxon (maximum 3 muM) and anti-NTE activity of mipafox (250 muM) in SY5Y cells were prevented by biodegradation with OPH. Paraoxon 26-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 9-13 16934462-2 2006 Their potency to reactivate AChE inhibited by nerve agent tabun and insecticide paraoxon was tested in vitro and compared to pralidoxime, HI-6, obidoxime, K027, and K048. Paraoxon 80-88 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 16934462-3 2006 According to the results, three compounds seem to be promising against paraoxon-inhibited AChE. Paraoxon 71-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-130 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 16769211-3 2006 Here, we applied the localized surface plasmon resonance (LSPR) of gold nanoparticles covalently coupled with acetylcholinesterase (AChE) to create a biosensor for detecting an example of serial signals responding to paraoxon in the range of 1-100 ppb by an AChE modified LSPR sensor immersing in a 0.05 mM ACh solution. Paraoxon 217-225 acetylcholinesterase (Cartwright blood group) Homo sapiens 258-262 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Paraoxon 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 94-98 16769211-4 2006 The underlying mechanism is that paraoxon prevents acetylcholine chloride (ACh) reacting with AChE by destroying the OH bond of serine in AChE. Paraoxon 33-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-142 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Paraoxon 224-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 16769211-5 2006 We found that the AChE modified LSPR sensors prepared by incubation with 12.5 mU/mL of AChE in phosphate buffer solution at pH 8.5 room temperature for 14 h have the best linear inhibition response with a 0.234 ppb limit of paraoxon detection. Paraoxon 224-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 16769211-9 2006 In conclusion, we demonstrated that the AChE modified LSPR sensors can be used to determine the concentration of paraoxon biosensor with high sensitive and stable characteristics. Paraoxon 113-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 17723708-7 2006 The LODs of the AChE biosensor without sample preconcentration were 8 x 10(-8) M for paraoxon and 1 x 10(-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10(-8) M for paraoxon and 2.5 x 10(-8) M for dichlorvos. Paraoxon 85-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17723708-7 2006 The LODs of the AChE biosensor without sample preconcentration were 8 x 10(-8) M for paraoxon and 1 x 10(-7) M dichlorvos and the LOD obtained after the preconcentration step were 2.5 x 10(-8) M for paraoxon and 2.5 x 10(-8) M for dichlorvos. Paraoxon 199-207 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 17723768-5 2006 AChE-based biosensors have demonstrated a higher sensitivity towards aldicarb (50% inhibition with 50 ppb) and carbaryl (50% inhibition with 85 ppb) while BChE biosensors have shown a higher affinity towards paraoxon (50% inhibition with 4 ppb) and chlorpyrifos-methyl oxon (50% inhibition with 1 ppb). Paraoxon 208-216 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 10421473-7 1999 Partially purified hemolymph AChE was inhibited by either 10 microM of echothiophate or 5 microM of paraoxon. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 16403852-3 2006 The present article documents conditions in which the inhibitory capacity of paraoxon towards human recombinant acetylcholinesterase appears to change as a function of oxon concentration (as evidenced by a changing k(i)), with the inhibitory capacity of individual oxon molecules increasing at lower oxon concentrations. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 16448058-7 2006 The developed PDDA/AChE/PDDA/CNT/GC biosensor integrated into a flow injection system was used to monitor organophosphate pesticides and nerve agents, such as paraoxon. Paraoxon 159-167 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 16167316-4 2005 Recently, the clinically used reversible AChE inhibitors metoclopramide (MCP) and ranitidine (RAN) were shown to exhibit some protective effect against the OP pesticide paraoxon in vitro and in vivo. Paraoxon 169-177 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 12373455-3 2002 The reactivating properties of the two salts were compared on human erythrocyte AChE inhibited with paraoxon, sarin, cyclosarin and agent VX. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 80-84 11453739-5 2001 We further show that the aging product of paraoxon-AChE adduct is identical to the aging product of the tabun-AChE conjugate. Paraoxon 42-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-55 11180275-5 2001 Effects of PRX on the inhibition of AChE by POX were assessed in vitro in plasma of 12 (six male and six female) healthy human volunteers. Paraoxon 44-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 11180275-9 2001 In the micro- and millimolar ranges, PRX is able to protect in vitro AChE from inhibition by POX when added to human plasma prior to POX or when incubated with POX prior to addition to plasma. Paraoxon 93-96 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). Paraoxon 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-48 10942900-0 2000 L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600). Paraoxon 75-83 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-54 10942900-5 2000 Effects of lactate on the inhibition of AChE by POX were assessed in vitro in plasma of 12 (six male, six female) healthy human volunteers. Paraoxon 48-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-44 10942900-8 2000 In the micro- and millimolar ranges, lactate is able to protect in vitro AChE from inhibition by POX when added to human plasma prior to POX or when incubated with POX prior to addition to plasma. Paraoxon 97-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 73-77 16193529-10 2006 Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood were measured photometrically in the presence of different POX concentrations and the IC50 was calculated. Paraoxon 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 16193529-10 2006 Red blood cell (RBC) acetylcholinesterase (AChE) activities in whole blood were measured photometrically in the presence of different POX concentrations and the IC50 was calculated. Paraoxon 134-137 acetylcholinesterase (Cartwright blood group) Homo sapiens 43-47 11708144-0 2001 Flow-injection spectrophotometric determination of paraoxon by its inhibitory effect on the enzyme acetylcholinesterase. Paraoxon 51-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 10022255-5 1998 The species specificity of this phenomenon was clearly displayed in Xenopus tadpoles expressing recombinant human AChE, which was far more sensitive than the frog enzyme to in vivo paraoxon inhibition. Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-118 9988368-11 1998 Unexpectedly, paraoxon levels occasionally reincreased during treatment and resulted in re-inhibition of AChE, bearing some resemblance to the Intermediate Syndrome. Paraoxon 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 9988368-13 1998 The paraoxon concentrations measured fitted satisfactorily the values calculated from the kinetic constants previously obtained for AChE inhibition and obidoxime-induced reactivation in vitro. Paraoxon 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 132-136 8783813-3 1996 For this purpose human erythrocyte AChE (EC 3.1.1.7) was inhibited (30 min) by chlorfenvinphos, dichlorvos, dicrotophos, heptenophos, mevinphos, monocrotophos, paraoxon, phosphamidon, trichlorfon, malaoxon, omethoate, oxydemeton-methyl or methamidophos by 85-98% of control. Paraoxon 160-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-39 9744565-5 1998 The bimolecular rate constants (ki) for inhibition by paraoxon of recombinant human (rH) AChE, recombinant mouse (rM) AChE, and fetal bovine serum (FBS) AChE were 7.0, 4.0, and 3.2 x 10(5) M(-1) min(-1). Paraoxon 54-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 7853361-3 1994 Paraoxon was 15-fold more potent in inhibiting AChE than DFP, while the percent aging following phosphorylation by diisopropylfluorophosphate (DFP) was much higher. Paraoxon 0-8 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 7853361-4 1994 Sodium fluoride (NaF), the most effective protectant against phosphorylation and aging, and the quaternary ammonium compounds reduced significantly AChE inhibition by DFP and paraoxon, to similar degrees. Paraoxon 175-183 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152 8134223-13 1994 In vitro, oximes reactivated acetylcholinesterase inhibited with paraoxon, whereas no significant effect of oximes on carbamylated enzyme activity was observed. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-49 8264551-3 1993 Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Paraoxon 285-293 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-75 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Paraoxon 99-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 32583098-3 2020 The reactivation was notable for both AChE and BChE inhibited by VX, cyclosarin, sarin and paraoxon, if quinuclidinium compounds contained the benzyl group attached to the quinuclidinium moiety. Paraoxon 91-99 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 32397331-0 2020 Patterned Superhydrophobic SERS Substrates for Sample Pre-Concentration and Demonstration of Its Utility through Monitoring of Inhibitory Effects of Paraoxon and Carbaryl on AChE. Paraoxon 149-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 32397331-10 2020 Inhibitory effects of paraoxon and carbaryl on AChE were evaluated from the TC peak intensity. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 6-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-185 31675511-2 2020 Using paraoxon (POX) as a model organophosphate, it was shown that 6-methyluracil derivatives linked with hydroxamic acid are able to reactivate POX-inhibited human acetylcholinesterase (AChE) in vitro. Paraoxon 16-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 34506764-5 2021 A moderate accelerating effect of alpha-T on phosphorylation by paraoxon was also observed after pre-incubation of AChE in the presence of alpha-T. Paraoxon 64-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-119 3955054-1 1986 The kinetics of the irreversible inhibition of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) by diisopropyl fluorophosphate and paraoxon have been studied by the approach of following the substrate reaction continuously in the presence of both the substrate and the inhibitor based on kinetic equations previously derived (Tsou, C.-L. (1965) Acta Biochim. Paraoxon 147-155 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 6497653-12 1984 dm-3 oximes the percent of reactivation was: 0-17% for paraoxon-inhibited AChE, 9-49% for sarin-inhibited AChE, 16-65% for VX-inhibited AChE, 0-8% for tabun-inhibited AChE, and 0-4% for soman-inhibited AChE. Paraoxon 55-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-78 6297513-3 1982 Acetylcholinesterase (AChE) (EC 3.1.1.7) of human brain was inhibited in vitro by paraoxon and DFP. Paraoxon 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 6297513-3 1982 Acetylcholinesterase (AChE) (EC 3.1.1.7) of human brain was inhibited in vitro by paraoxon and DFP. Paraoxon 82-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 4253834-0 1970 [Determination of acetylcholinesterase concentration by phosphorylation with paraoxon]. Paraoxon 77-85 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-38 33563155-14 2022 Further, in-vitro enzymatic assay indicated reasonable reactivation potential of the oximes against paraoxon-inhibited AChE. Paraoxon 100-108 acetylcholinesterase (Cartwright blood group) Homo sapiens 119-123 32454005-5 2020 All compounds were assessed for their ability to reactivate human acetylcholinesterase inhibited by the nerve agents VX, tabun, sarin, cyclosarin and paraoxon in vitro. Paraoxon 150-158 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-86 31276662-3 2019 Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). Paraoxon 109-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-138 31360962-2 2019 They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 130-150 30424582-0 2018 Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Paraoxon 124-132 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 31170561-8 2019 The value of free binding energy of paraoxon with peripheral anionic site of acetylcholinesterase (AChE) has been calculated as well. Paraoxon 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-97 31170561-8 2019 The value of free binding energy of paraoxon with peripheral anionic site of acetylcholinesterase (AChE) has been calculated as well. Paraoxon 36-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 31170561-9 2019 It has been revealed that the aptamers found bind paraoxon more effectively than AChE. Paraoxon 50-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 30312685-4 2018 This in vitro study was undertaken to determine reactivity, affinity and overall reactivation constants of 3 l, the reference compound ADOC and two structural analogues with human AChE inhibited by paraoxon, sarin, cyclosarin and VX. Paraoxon 198-206 acetylcholinesterase (Cartwright blood group) Homo sapiens 180-184 29735900-0 2018 Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Paraoxon 162-170 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. Paraoxon 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 30096649-7 2018 In this paper several structural derivatives of ADOC were synthesized and screened for their ability to reactivate human AChE (hAChE) inhibited by the nerve agents VX, sarin, tabun, cyclosarin and paraoxon. Paraoxon 197-205 acetylcholinesterase (Cartwright blood group) Homo sapiens 127-132 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 29773682-2 2018 To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-). Paraoxon 81-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 30205495-5 2018 The novel compounds were prepared, evaluated in vitro on human AChE (HssAChE) inhibited by tabun, paraoxon, methylparaoxon or DFP and compared to commercial HssAChE reactivators (pralidoxime, methoxime, trimedoxime, obidoxime, asoxime) or previously prepared compounds (K048, K074, K075, K203). Paraoxon 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-67 29652477-6 2018 The ability of the targeted SNs to sense an inhibiting effect of paraoxon on enzymatic activity of AChE in ex vivo conditions provides a way of mimicking external stimuli effects on enzymatic processes in the isolated muscles. Paraoxon 65-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 29451128-6 2018 The entrapped AChE hydrolyzed paraoxon to produce p-nitrophenol within the hydrogel microstructure, which subsequently quenched the fluorescence of the QDs on the surface of Ag@Silica. Paraoxon 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 28722512-7 2018 In vitro the intrinsic ability of the oximes to inhibit AChE (IC50) and their reactivation potency (R50) when used in paraoxon inhibited human RBC-AChE was determined. Paraoxon 118-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 27251198-6 2016 Owing to the capability of organophosphorus pesticides to inhibit AChE, this biosensor was used to detect these pollutants, and paraoxon was taken as model compound. Paraoxon 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 29201079-7 2017 Then, more effective reactivatorsoximes in terms of binding energy and orientation within the active site were synthesized and evaluated in-vitro on human AChE (hAChE) inhibited by paraoxon and compared to standard hAChE reactivators (2-PAM and obidoxime). Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 155-159 29201079-7 2017 Then, more effective reactivatorsoximes in terms of binding energy and orientation within the active site were synthesized and evaluated in-vitro on human AChE (hAChE) inhibited by paraoxon and compared to standard hAChE reactivators (2-PAM and obidoxime). Paraoxon 181-189 acetylcholinesterase (Cartwright blood group) Homo sapiens 161-166 27494215-6 2016 Experimentally, six compounds were found with reactivation capabilities comparable to, or exceeding, those of 2-pralidoxime (2-PAM) against a panel of AChE inactivated by paraoxon, diisopropylfluorophosphate (DFP), fenamiphos, and methamidophos. Paraoxon 171-179 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 27191504-0 2016 Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. Paraoxon 14-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 27191504-4 2016 We have solved structures of human acetylcholinesterase in different states in complex with the organophosphate insecticide, paraoxon, and oximes. Paraoxon 125-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 27191504-8 2016 Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation. Paraoxon 22-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-67 27260432-5 2016 The detection limits of paraoxon and dimethoate were 0.7nM and 3.9nM, which were lower than the reported AChE biosensor. Paraoxon 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 26965078-5 2016 This was followed by NIMP then paraoxon and DFP with rat and mouse brain AChE but DFP was a more potent inhibitor than NIMP and paraoxon with human AChE. Paraoxon 128-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-152