PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22100607-0	2012	Inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by chlorpyrifos oxon, paraoxon and methyl paraoxon.	Paraoxon	107-115	carboxylesterase 1	Homo sapiens	32-56	
22100607-8	2012	Here, we determined the potency of inhibition (IC(50) values; 15 min preincubation, enzyme and inhibitor) of recombinant CES1, CES2, and MGL by chlorpyrifos oxon, paraoxon and methyl paraoxon.	Paraoxon	183-191	carboxylesterase 1	Homo sapiens	121-125	
22100607-9	2012	The order of potency for these three oxons with CES1, CES2, and MGL was chlorpyrifos oxon>paraoxon>methyl paraoxon, although the difference in potency for chlorpyrifos oxon with CES1 and CES2 did not reach statistical significance.	Paraoxon	93-101	carboxylesterase 1	Homo sapiens	48-52	
22100607-9	2012	The order of potency for these three oxons with CES1, CES2, and MGL was chlorpyrifos oxon>paraoxon>methyl paraoxon, although the difference in potency for chlorpyrifos oxon with CES1 and CES2 did not reach statistical significance.	Paraoxon	112-120	carboxylesterase 1	Homo sapiens	48-52	
22100607-10	2012	We also determined the bimolecular rate constants (k(inact)/K(I)) for the covalent reaction of chlorpyrifos oxon, paraoxon and methyl paraoxon with CES1 and CES2.	Paraoxon	114-122	carboxylesterase 1	Homo sapiens	148-152	
22100607-10	2012	We also determined the bimolecular rate constants (k(inact)/K(I)) for the covalent reaction of chlorpyrifos oxon, paraoxon and methyl paraoxon with CES1 and CES2.	Paraoxon	134-142	carboxylesterase 1	Homo sapiens	148-152	
22943979-9	2012	We also determined kinetic constants for spontaneous reactivation of CES1 carbamoylated by either JZL184 or URB597 and CES1 diethylphosphorylated by paraoxon.	Paraoxon	149-157	carboxylesterase 1	Homo sapiens	69-73	
22943979-9	2012	We also determined kinetic constants for spontaneous reactivation of CES1 carbamoylated by either JZL184 or URB597 and CES1 diethylphosphorylated by paraoxon.	Paraoxon	149-157	carboxylesterase 1	Homo sapiens	119-123	
22100607-8	2012	Here, we determined the potency of inhibition (IC(50) values; 15 min preincubation, enzyme and inhibitor) of recombinant CES1, CES2, and MGL by chlorpyrifos oxon, paraoxon and methyl paraoxon.	Paraoxon	163-171	carboxylesterase 1	Homo sapiens	121-125	
18762277-5	2008	Here, we show that CES1 protein is robustly expressed in human THP-1 monocytes/macrophages and its biochemical activity inhibited following treatment of cell lysates and intact cells with chlorpyrifos oxon, paraoxon, or methyl paraoxon (with nanomolar IC(50) values) or after immunodepletion of CES1 protein.	Paraoxon	207-215	carboxylesterase 1	Homo sapiens	19-23	
18762277-5	2008	Here, we show that CES1 protein is robustly expressed in human THP-1 monocytes/macrophages and its biochemical activity inhibited following treatment of cell lysates and intact cells with chlorpyrifos oxon, paraoxon, or methyl paraoxon (with nanomolar IC(50) values) or after immunodepletion of CES1 protein.	Paraoxon	227-235	carboxylesterase 1	Homo sapiens	19-23	
21509954-6	2011	hCE1 silica particles in a column chromatography format respond to the presence of the OP pesticides paraoxon and dimethyl-p-nitrophenyl phosphate in solution.	Paraoxon	101-109	carboxylesterase 1	Homo sapiens	0-4