PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18803983-9	2008	Carbamazepine, phenytoin, phenobarbital, and primidone were found to have prominent cytochrome P450 (CYP) enzyme-induction effects, while valproic acid had an inhibitory effect.	Primidone	45-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	84-99	
18803983-9	2008	Carbamazepine, phenytoin, phenobarbital, and primidone were found to have prominent cytochrome P450 (CYP) enzyme-induction effects, while valproic acid had an inhibitory effect.	Primidone	45-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-104	
16487217-4	2006	Carbamazepine, phenytoin, phenobarbital and primidone induce many cytochrome P450 (CYP) and glucuronyl transferase (GT) enzymes, and can reduce drastically the serum concentration of associated drugs which are substrates of the same enzymes.	Primidone	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	83-86	
10380060-5	1999	Phenytoin, phenobarbiral, primidone and carbamazepine induce CYP and UDPGT enzymes while valproic acid inhibits them.	Primidone	26-35	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	61-64	
16487217-4	2006	Carbamazepine, phenytoin, phenobarbital and primidone induce many cytochrome P450 (CYP) and glucuronyl transferase (GT) enzymes, and can reduce drastically the serum concentration of associated drugs which are substrates of the same enzymes.	Primidone	44-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-81	
15038401-3	2004	Potent inductors of CYP isoenzymes are carbamazepine, phenobarbital, phenytoin, and primidone, thereby decreasing not only their own plasma levels and efficacy but also that of other antiepileptics and other drugs.	Primidone	84-93	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	20-23	
7173298-6	1982	Subjects with a normal liver undergoing treatment with enzyme-inducing drugs, such as phenytoin, phenobarbital and primidone, had higher HDL cholesterol, apoproteins A-I and A-II, HDL cholesterol/total cholesterol ratio, cytochrome P-450 and antipyrine clearance rate than subjects not receiving such therapy.	Primidone	115-124	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	221-237