PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20223014-2 2006 The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). Valine 83-89 catechol-O-methyltransferase Homo sapiens 63-67 15654584-10 2005 COMT genotype, however, affected prefrontal cognition in ADHD: ADHD children who were homozygous for the valine variant had significantly better sustained attention than those ADHD children possessing at least one copy of the methionine variant. Valine 105-111 catechol-O-methyltransferase Homo sapiens 0-4 17071544-1 2006 A number of studies have reported an association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and neuropsychological traits in patients with schizophrenia, their relatives and healthy controls, with the Met allele carriers performing better on neurocognitive tasks than those with the Val allele. Valine 98-101 catechol-O-methyltransferase Homo sapiens 57-85 17071544-1 2006 A number of studies have reported an association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and neuropsychological traits in patients with schizophrenia, their relatives and healthy controls, with the Met allele carriers performing better on neurocognitive tasks than those with the Val allele. Valine 98-101 catechol-O-methyltransferase Homo sapiens 87-91 16126332-5 2005 RESULTS: Patients with the Val/Val genotype of COMT had a significantly higher PSA-progression-free rate as compared to those with the Val/Met or Met/Met genotype (p=0.027). Valine 27-30 catechol-O-methyltransferase Homo sapiens 47-51 16126332-5 2005 RESULTS: Patients with the Val/Val genotype of COMT had a significantly higher PSA-progression-free rate as compared to those with the Val/Met or Met/Met genotype (p=0.027). Valine 31-34 catechol-O-methyltransferase Homo sapiens 47-51 16387984-2 2005 High enzyme activity (COMT Val) and low enzyme activity (COMT Met) are functional polymorphisms resulting from a G to A transition in exon 4 (codon 158) of the human COMT gene. Valine 27-30 catechol-O-methyltransferase Homo sapiens 22-26 15985686-3 2005 In this cross-sectional study we investigated associations between the COMT val158met polymorphism, which results in a 60-75% difference in enzyme activity between the val (high activity = H) and the met (low activity = L) variant, and skeletal phenotypes in 246 healthy pre/early pubertal girls. Valine 76-79 catechol-O-methyltransferase Homo sapiens 71-75 16542182-3 2006 A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Valine 2-8 catechol-O-methyltransferase Homo sapiens 40-68 16542182-3 2006 A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Valine 2-8 catechol-O-methyltransferase Homo sapiens 93-97 16475806-1 2006 The human gene for catechol O-methyltransferase (COMT) contains a common polymorphism that results in substitution of methionine (M) for valine (V) at residue 108 of the soluble form of the protein. Valine 137-143 catechol-O-methyltransferase Homo sapiens 19-47 16475806-1 2006 The human gene for catechol O-methyltransferase (COMT) contains a common polymorphism that results in substitution of methionine (M) for valine (V) at residue 108 of the soluble form of the protein. Valine 137-143 catechol-O-methyltransferase Homo sapiens 49-53 16330500-9 2006 Individuals homozygous for the Val-COMT allele demonstrated significant reduction of volumes in the left anterior cingulate cortex (ACC) and the right middle temporal gyrus (MTG) compared to Met-COMT carriers. Valine 31-34 catechol-O-methyltransferase Homo sapiens 35-39 16330500-9 2006 Individuals homozygous for the Val-COMT allele demonstrated significant reduction of volumes in the left anterior cingulate cortex (ACC) and the right middle temporal gyrus (MTG) compared to Met-COMT carriers. Valine 31-34 catechol-O-methyltransferase Homo sapiens 195-199 16490416-2 2006 A common variant of the COMT gene (val(108/158)met) has been widely reported to affect pre-frontally mediated working memory function, with the high-activity val allele associated with poorest performance across a number of tests sensitive to updating and target detection. Valine 35-38 catechol-O-methyltransferase Homo sapiens 24-28 16275815-4 2005 Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene. Valine 78-84 catechol-O-methyltransferase Homo sapiens 111-139 16275815-4 2005 Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene. Valine 78-84 catechol-O-methyltransferase Homo sapiens 141-145 16027741-3 2005 Recently, sex-differential association of a three-locus haplotype, including a G-->A transition at codon 108/158 of catechol-O-methyltransferase (COMT) resulting in a Val-->Met substitution, has been reported to confer an increased risk for schizophrenia. Valine 167-170 catechol-O-methyltransferase Homo sapiens 116-144 16027741-3 2005 Recently, sex-differential association of a three-locus haplotype, including a G-->A transition at codon 108/158 of catechol-O-methyltransferase (COMT) resulting in a Val-->Met substitution, has been reported to confer an increased risk for schizophrenia. Valine 167-170 catechol-O-methyltransferase Homo sapiens 146-150 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Valine 13-19 catechol-O-methyltransferase Homo sapiens 51-79 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Valine 13-19 catechol-O-methyltransferase Homo sapiens 81-85 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Valine 13-19 catechol-O-methyltransferase Homo sapiens 165-169 16135635-5 2005 CONCLUSIONS: The data suggest that the valine allele of COMT does not increase susceptibility to schizophrenia in Europeans and that the Ashkenazi or Irish haplotype does not increase susceptibility. Valine 39-45 catechol-O-methyltransferase Homo sapiens 56-60 15505638-2 2005 The interest in COMT as a candidate SZ risk factor has led to numerous case-control and family-based studies, with the majority placing emphasis on examining a functional Val/Met polymorphism within this enzyme. Valine 171-174 catechol-O-methyltransferase Homo sapiens 16-20 15583702-5 2005 These findings suggest that the COMT Val/Val genotype may be involved in EO-MDD or may be in linkage disequilibrium with a different causative polymorphism in the vicinity. Valine 37-40 catechol-O-methyltransferase Homo sapiens 32-36 15652872-1 2005 BACKGROUND: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. Valine 46-49 catechol-O-methyltransferase Homo sapiens 62-90 15645182-3 2005 A coding polymorphism of the COMT gene at codon 108/158 (soluble/membrane-bound form) causing a valine to methionine substitution has been shown to influence enzyme activity, but its association with schizophrenia is inconclusive. Valine 96-102 catechol-O-methyltransferase Homo sapiens 29-33 15635644-3 2005 Moreover, a functional Val158Met polymorphism in COMT that alters the activity of the encoded protein has been strongly implicated in frontal lobe function, with the high activity Valine allele being associated with poorer performance, and ADHD is thought to involve fronto-striatal pathways. Valine 180-186 catechol-O-methyltransferase Homo sapiens 49-53 15652872-1 2005 BACKGROUND: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. Valine 46-49 catechol-O-methyltransferase Homo sapiens 97-101 15537444-6 2004 There is a functional polymorphism in the COMT gene (val158met), resulting in a 60-75% difference in enzyme activity between the val (high activity [H]) and met (low activity [L]) variants. Valine 53-56 catechol-O-methyltransferase Homo sapiens 42-46 15457404-9 2004 Thus, although we cannot exclude a more complex genetic basis for functional effects of COMT, Val is a predominant factor that determines higher COMT activity in the prefrontal cortex, which presumably leads to lower synaptic dopamine levels and relatively deleterious prefrontal function. Valine 94-97 catechol-O-methyltransferase Homo sapiens 145-149 15261699-4 2004 We genotyped the valine/methionine polymorphism of codon 108/158 in the catechol-O-methyltransferase (COMT) gene, the 30-bp repeat polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, and the A/G polymorphism in intron 13 of the monoamine oxidase B (MAOB) gene in 206 Japanese patients with schizophrenia. Valine 17-23 catechol-O-methyltransferase Homo sapiens 72-100 15127078-4 2004 The COMT 158Val/Met polymorphism affects COMT activity, that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 12-15 catechol-O-methyltransferase Homo sapiens 4-8 15127078-4 2004 The COMT 158Val/Met polymorphism affects COMT activity, that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 12-15 catechol-O-methyltransferase Homo sapiens 41-45 15127078-4 2004 The COMT 158Val/Met polymorphism affects COMT activity, that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 12-15 catechol-O-methyltransferase Homo sapiens 41-45 15363545-1 2004 A single nucleotide polymorphism in the COMT (catechol-O-methyltransferase) gene that alters the amino acid sequence at codon 108 of S-COMT from val to met (val108met polymorphism) has been associated with a number of diseases and neuropsychiatric disorders. Valine 145-148 catechol-O-methyltransferase Homo sapiens 40-44 15363545-1 2004 A single nucleotide polymorphism in the COMT (catechol-O-methyltransferase) gene that alters the amino acid sequence at codon 108 of S-COMT from val to met (val108met polymorphism) has been associated with a number of diseases and neuropsychiatric disorders. Valine 145-148 catechol-O-methyltransferase Homo sapiens 46-74 15363545-1 2004 A single nucleotide polymorphism in the COMT (catechol-O-methyltransferase) gene that alters the amino acid sequence at codon 108 of S-COMT from val to met (val108met polymorphism) has been associated with a number of diseases and neuropsychiatric disorders. Valine 145-148 catechol-O-methyltransferase Homo sapiens 135-139 15465976-1 2004 OBJECTIVE: Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val(108/158)Met) in the catechol O-methyltransferase (COMT) gene that affects dopamine inactivation in the prefrontal cortex. Valine 219-222 catechol-O-methyltransferase Homo sapiens 243-271 15465976-1 2004 OBJECTIVE: Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val(108/158)Met) in the catechol O-methyltransferase (COMT) gene that affects dopamine inactivation in the prefrontal cortex. Valine 219-222 catechol-O-methyltransferase Homo sapiens 273-277 15261699-4 2004 We genotyped the valine/methionine polymorphism of codon 108/158 in the catechol-O-methyltransferase (COMT) gene, the 30-bp repeat polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, and the A/G polymorphism in intron 13 of the monoamine oxidase B (MAOB) gene in 206 Japanese patients with schizophrenia. Valine 17-23 catechol-O-methyltransferase Homo sapiens 102-106 11556837-4 2001 The gene coding for COMT protein contains a single-nucleotide polymorphism (SNP), resulting in an amino acid shift Val-->Met, which has been shown to determine high- and low-activity configuration of the enzyme. Valine 115-118 catechol-O-methyltransferase Homo sapiens 20-24 14706432-1 2004 BACKGROUND: A common polymorphism in the catechol-O-methyltransferase gene involves a valine to methionine mutation that results in a threefold to fourfold decrease in enzyme activity. Valine 86-92 catechol-O-methyltransferase Homo sapiens 41-69 12168735-6 2002 CONCLUSIONS: Our results suggest that the valine to methionine polymorphism in exon 4 of the COMT gene is not associated with the risk of endometriosis compared to a surgical control population. Valine 42-48 catechol-O-methyltransferase Homo sapiens 93-97 14754787-0 2004 Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. Valine 29-32 catechol-O-methyltransferase Homo sapiens 0-28 12799619-2 2003 A functional polymorphism of COMT, Val(108/158) Met, affects prefrontal function, and the high-activity Val allele has been reported to be a genetic risk factor for schizophrenia. Valine 35-38 catechol-O-methyltransferase Homo sapiens 29-33 12799619-2 2003 A functional polymorphism of COMT, Val(108/158) Met, affects prefrontal function, and the high-activity Val allele has been reported to be a genetic risk factor for schizophrenia. Valine 104-107 catechol-O-methyltransferase Homo sapiens 29-33 12707935-2 2003 The molecular basis of COMT thermolability, that leads to three to fourfold differences in enzyme activity, is due to a substitution of valine with methionine in the Val158/108Met polymorphism. Valine 136-142 catechol-O-methyltransferase Homo sapiens 23-27 12657658-2 2003 The COMT valine allele, associated with relatively poor prefrontal function, is also a gene that may increase risk for schizophrenia. Valine 9-15 catechol-O-methyltransferase Homo sapiens 4-8 12657658-5 2003 We measured tyrosine hydroxylase (TH) mRNA in mesencephalic dopamine neurons in human brain and found that the COMT valine allele is also associated with increased TH gene expression, especially in neuronal populations that project to the striatum. Valine 116-122 catechol-O-methyltransferase Homo sapiens 111-115 12036914-10 2002 A portion (71.9%) of cases either carried or was homozygous for the Val/Met variant of COMT, compared with 76.9% of controls (P = 0.27). Valine 68-71 catechol-O-methyltransferase Homo sapiens 87-91 11693181-2 2001 A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane-bound COMT, respectively, whereby a G to A transition results in a valine to methionine substitution. Valine 156-162 catechol-O-methyltransferase Homo sapiens 95-99 10490706-0 1999 Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Valine 162-165 catechol-O-methyltransferase Homo sapiens 33-61 11381111-9 2001 These data suggest that the COMT Val allele, because it increases prefrontal dopamine catabolism, impairs prefrontal cognition and physiology, and by this mechanism slightly increases risk for schizophrenia. Valine 33-36 catechol-O-methyltransferase Homo sapiens 28-32 11054766-0 2000 Confirmation of an excess of the high enzyme activity COMT val allele in heroin addicts in a family-based haplotype relative risk study. Valine 59-62 catechol-O-methyltransferase Homo sapiens 54-58 10629435-3 2000 TPQ scores were examined in 577 normal subjects inventoried for two common genetic polymorphisms, the catechol O-methyltransferase (COMT) valine to methionine (val to met) amino acid substitution that determines high and low enzyme activity, and the serotonin transporter promoter region 44 bp deletion (5-HTTLPR) linked in some studies to harm avoidance or neuroticism. Valine 138-144 catechol-O-methyltransferase Homo sapiens 102-130 10629435-3 2000 TPQ scores were examined in 577 normal subjects inventoried for two common genetic polymorphisms, the catechol O-methyltransferase (COMT) valine to methionine (val to met) amino acid substitution that determines high and low enzyme activity, and the serotonin transporter promoter region 44 bp deletion (5-HTTLPR) linked in some studies to harm avoidance or neuroticism. Valine 138-144 catechol-O-methyltransferase Homo sapiens 132-136 10629435-3 2000 TPQ scores were examined in 577 normal subjects inventoried for two common genetic polymorphisms, the catechol O-methyltransferase (COMT) valine to methionine (val to met) amino acid substitution that determines high and low enzyme activity, and the serotonin transporter promoter region 44 bp deletion (5-HTTLPR) linked in some studies to harm avoidance or neuroticism. Valine 138-141 catechol-O-methyltransferase Homo sapiens 102-130 10629435-3 2000 TPQ scores were examined in 577 normal subjects inventoried for two common genetic polymorphisms, the catechol O-methyltransferase (COMT) valine to methionine (val to met) amino acid substitution that determines high and low enzyme activity, and the serotonin transporter promoter region 44 bp deletion (5-HTTLPR) linked in some studies to harm avoidance or neuroticism. Valine 138-141 catechol-O-methyltransferase Homo sapiens 132-136 10490706-0 1999 Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the high-enzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Valine 162-165 catechol-O-methyltransferase Homo sapiens 63-67 9159741-1 1997 High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Valine 127-133 catechol-O-methyltransferase Homo sapiens 13-41 9682265-3 1998 A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane bound COMT protein, respectively, whereby a G to A transition results in a valine to methionine substitution, rendering the protein more thermolabile. Valine 164-170 catechol-O-methyltransferase Homo sapiens 95-99 9535125-2 1998 A functional COMT gene polymorphism influencing the enzyme activities, the high activity (val-108) and the low activity allele (met-108), was recently confirmed. Valine 90-93 catechol-O-methyltransferase Homo sapiens 13-17 10459407-2 1999 The NlaIII restriction site polymorphism (RSP) at COMT is a G<-->A (site absent<-->site present) single nucleotide polymorphism (SNP) at nucleotide 322/472 (in the short or long mRNA) that results in a Val<-->Met polymorphism at amino acid 108/158 (in soluble or membrane-bound) COMT protein and different enzyme activity levels, high for Val, low for Met. Valine 214-217 catechol-O-methyltransferase Homo sapiens 50-54 10459407-2 1999 The NlaIII restriction site polymorphism (RSP) at COMT is a G<-->A (site absent<-->site present) single nucleotide polymorphism (SNP) at nucleotide 322/472 (in the short or long mRNA) that results in a Val<-->Met polymorphism at amino acid 108/158 (in soluble or membrane-bound) COMT protein and different enzyme activity levels, high for Val, low for Met. Valine 214-217 catechol-O-methyltransferase Homo sapiens 297-301 10459407-2 1999 The NlaIII restriction site polymorphism (RSP) at COMT is a G<-->A (site absent<-->site present) single nucleotide polymorphism (SNP) at nucleotide 322/472 (in the short or long mRNA) that results in a Val<-->Met polymorphism at amino acid 108/158 (in soluble or membrane-bound) COMT protein and different enzyme activity levels, high for Val, low for Met. Valine 357-360 catechol-O-methyltransferase Homo sapiens 50-54 10459407-2 1999 The NlaIII restriction site polymorphism (RSP) at COMT is a G<-->A (site absent<-->site present) single nucleotide polymorphism (SNP) at nucleotide 322/472 (in the short or long mRNA) that results in a Val<-->Met polymorphism at amino acid 108/158 (in soluble or membrane-bound) COMT protein and different enzyme activity levels, high for Val, low for Met. Valine 357-360 catechol-O-methyltransferase Homo sapiens 297-301 9159741-1 1997 High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Valine 127-133 catechol-O-methyltransferase Homo sapiens 43-47 9159741-1 1997 High and low catechol-O-methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Valine 127-133 catechol-O-methyltransferase Homo sapiens 221-225 9110364-4 1997 In red blood cells from individuals homozygous for G at nucleotide position 544 coding for Val-158, the activity of COMT ranged from 0.55-1.03 pmol min-1 mg-1 protein, and in individuals homozygous for A at position 544 coding for Met-158, the activity ranged from 0.21-0.43 pmol min-1 mg-1. Valine 91-94 catechol-O-methyltransferase Homo sapiens 116-120 9264133-5 1997 A relatively low activity allele is associated with a methionine residue at amino acid 158 of membrane bound COMT whereas a high activity variant has a valine at this site. Valine 152-158 catechol-O-methyltransferase Homo sapiens 109-113 34015958-10 2022 Furthermore, individuals with the COMT methionine homozygous had higher FA and lower MD, RD, AD, and Cs values in the right rostral cingulum compared to the valine carriers across the entire adult life span. Valine 157-163 catechol-O-methyltransferase Homo sapiens 34-38 7703232-10 1995 Two recently published human COMT cDNA sequences differed in the position of S-COMT amino acid 108, the residue being either Val-108 [Lundstrom et al. Valine 125-128 catechol-O-methyltransferase Homo sapiens 29-33 8807664-3 1996 We now show that this is due to G-->A transition at codon 158 of the COMT gene that results in a valine to methionine substitution. Valine 100-106 catechol-O-methyltransferase Homo sapiens 72-76 34814943-10 2021 We conclude that Val homozygotes of the COMT Val158Met polymorphism play a role in susceptibility to both depressive symptoms and NSSI. Valine 17-20 catechol-O-methyltransferase Homo sapiens 40-44 34285849-0 2021 Cannabis, Schizophrenia Risk and Genetics: A Case Report of a Patient With Homozygous Valine Catechol-O-Methyltransferase Polymorphism. Valine 86-92 catechol-O-methyltransferase Homo sapiens 93-121 34285849-7 2021 In addition, she had a homozygous valine COMT polymorphism, a genetic variant thought to be associated with a predisposition for schizophrenia in cannabis users. Valine 34-40 catechol-O-methyltransferase Homo sapiens 41-45 35295415-2 2021 Catechol-O-methyltransferase (COMT) rs4680, which encodes high-activity (val) or low-activity (met) enzyme variants, was previously associated with placebo response to sham-acupuncture in an IBS RCT. Valine 73-76 catechol-O-methyltransferase Homo sapiens 0-28 35295415-2 2021 Catechol-O-methyltransferase (COMT) rs4680, which encodes high-activity (val) or low-activity (met) enzyme variants, was previously associated with placebo response to sham-acupuncture in an IBS RCT. Valine 73-76 catechol-O-methyltransferase Homo sapiens 30-34 33124661-2 2021 The COMT gene polymorphism with methionine (Met) at codon 158 results in more dopamine (DA) in PFC and generally better EFs, while with valine (Val) at codon 158 the result is less PFC DA and generally poorer EFs. Valine 136-142 catechol-O-methyltransferase Homo sapiens 4-8 33124661-2 2021 The COMT gene polymorphism with methionine (Met) at codon 158 results in more dopamine (DA) in PFC and generally better EFs, while with valine (Val) at codon 158 the result is less PFC DA and generally poorer EFs. Valine 144-147 catechol-O-methyltransferase Homo sapiens 4-8 30240822-12 2018 And the val homozygotes of COMT may contribute to further cortical thinning in FES patients. Valine 8-11 catechol-O-methyltransferase Homo sapiens 27-31 32829984-1 2020 Dopaminergic activity in prefrontal cortex is modulated by the low (Met) and high (Val) activity of the rs4680 Val158Met single nucleotide polymorphism (SNP) in the Catechol-O-Methyltransferase (COMT) gene. Valine 83-86 catechol-O-methyltransferase Homo sapiens 165-193 32829984-7 2020 These findings suggest that impaired suppression of learned response patterns and reduced stability of mental sets may be a familial intermediate cognitive phenotype related to Val COMT allele genotype. Valine 177-180 catechol-O-methyltransferase Homo sapiens 181-185 32765586-8 2020 Significant gene-environment interactions were found, indicating that overall, carriers of at least one COMT158Met allele were more sensitive to early-life adversity, showing higher inattention and hyperactivity/impulsivity symptoms severity in childhood when exposed to high SES-risk factors in infancy, compared to Val-Val carriers. Valine 317-320 catechol-O-methyltransferase Homo sapiens 104-108 31107306-1 2019 OBJECTIVE: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Valine 15-18 catechol-O-methyltransferase Homo sapiens 81-109 31107306-1 2019 OBJECTIVE: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Valine 15-18 catechol-O-methyltransferase Homo sapiens 116-120 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Valine 144-147 catechol-O-methyltransferase Homo sapiens 102-130 31164811-2 2019 Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferase (COMT), with Val carriers exhibiting greater degradation of catecholamines than Met carriers. Valine 144-147 catechol-O-methyltransferase Homo sapiens 132-136 32739643-1 2020 The Met-allele of the COMT Val158Met polymorphism slows metabolism and increases bioavailability of dopamine (DA) in the prefrontal cortex compared to the Val-allele. Valine 27-30 catechol-O-methyltransferase Homo sapiens 22-26 32618128-10 2020 CONCLUSION: Our results suggest that vulnerability to suicide could be increased in the Val/Val genotype of COMT rs4680 and the CC genotype of rs4633 in patients with PTSD. Valine 88-91 catechol-O-methyltransferase Homo sapiens 108-112 32618128-10 2020 CONCLUSION: Our results suggest that vulnerability to suicide could be increased in the Val/Val genotype of COMT rs4680 and the CC genotype of rs4633 in patients with PTSD. Valine 92-95 catechol-O-methyltransferase Homo sapiens 108-112 32132825-2 2020 Critically, COMT Met (low-activity; high dopamine) allele carriers outperform Val (high-activity; low dopamine) homozygotes on a variety of cognitive tasks. Valine 78-81 catechol-O-methyltransferase Homo sapiens 12-16 32132825-6 2020 The Val allele advantage for stress resiliency is referred to as the COMT "warrior/ worrier" model. Valine 4-7 catechol-O-methyltransferase Homo sapiens 69-73 30894870-6 2019 This is the first study to report that Hi-AVH subjects" baseline brain functional features are influenced by their COMT genotypes and that the COMT-met genotype subjects exhibit better responses to dopamine antagonists but have more widespread GMV and gFCD reduction than subjects with the COMT-val genotype. Valine 295-298 catechol-O-methyltransferase Homo sapiens 143-147 30894870-6 2019 This is the first study to report that Hi-AVH subjects" baseline brain functional features are influenced by their COMT genotypes and that the COMT-met genotype subjects exhibit better responses to dopamine antagonists but have more widespread GMV and gFCD reduction than subjects with the COMT-val genotype. Valine 295-298 catechol-O-methyltransferase Homo sapiens 143-147 30211780-2 2019 A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. Valine 101-107 catechol-O-methyltransferase Homo sapiens 17-21 28687733-7 2017 Additionally, the functional connectivity of children with ADHD was modulated by COMT polymorphism, with Met-carriers exhibiting significantly lower functional connectivity than the Val/Val genotype. Valine 186-189 catechol-O-methyltransferase Homo sapiens 81-85 29429137-3 2018 Genotyping revealed a trend towards a reduced proportion of COMT Val/Met heterozygotes and a significantly increased frequency of the GAD1 rs3749034 C allele in schizophrenic patients relative to controls. Valine 65-68 catechol-O-methyltransferase Homo sapiens 60-64 29426301-10 2018 The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. Valine 48-51 catechol-O-methyltransferase Homo sapiens 4-8 29426301-10 2018 The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. Valine 78-81 catechol-O-methyltransferase Homo sapiens 4-8 29426301-10 2018 The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. Valine 78-81 catechol-O-methyltransferase Homo sapiens 4-8 29270116-3 2017 The activity level of the COMT enzyme are influenced by sex and the Val158Met polymorphism (rs4680) of the COMT gene, with male sex and Val alleles both being associated with higher bulk enzyme activity, and presumably lower PFC dopamine. Valine 68-71 catechol-O-methyltransferase Homo sapiens 26-30 29270116-3 2017 The activity level of the COMT enzyme are influenced by sex and the Val158Met polymorphism (rs4680) of the COMT gene, with male sex and Val alleles both being associated with higher bulk enzyme activity, and presumably lower PFC dopamine. Valine 68-71 catechol-O-methyltransferase Homo sapiens 107-111 28687733-7 2017 Additionally, the functional connectivity of children with ADHD was modulated by COMT polymorphism, with Met-carriers exhibiting significantly lower functional connectivity than the Val/Val genotype. Valine 182-185 catechol-O-methyltransferase Homo sapiens 81-85 29314589-9 2018 It also indicates that COMT Val homozygosity may be advantageous for cognitive shifting and prefrontal functions, at least during early childhood, and children who possess this variant may have a lower risk of developing future cognitive and social development issues. Valine 28-31 catechol-O-methyltransferase Homo sapiens 23-27 28803562-5 2018 Maternal maltreatment history significantly interacted with infant SLC6A3 and COMT genotypes, such that infants with more 10-repeat and valine alleles of SLC6A3 and COMT, respectively, relative to infants with fewer or no 10-repeat and valine alleles, utilized more independent (i.e., maladaptive) regulatory behavior if mother reported a more extensive maltreatment history, as opposed to less. Valine 136-142 catechol-O-methyltransferase Homo sapiens 78-82 28803562-5 2018 Maternal maltreatment history significantly interacted with infant SLC6A3 and COMT genotypes, such that infants with more 10-repeat and valine alleles of SLC6A3 and COMT, respectively, relative to infants with fewer or no 10-repeat and valine alleles, utilized more independent (i.e., maladaptive) regulatory behavior if mother reported a more extensive maltreatment history, as opposed to less. Valine 136-142 catechol-O-methyltransferase Homo sapiens 165-169 29198511-8 2017 RESULTS: 1 COMT gene-linked locus that was associated with PE symptoms in the present study, rs4680, is a well-documented functional polymorphism that causes a valine-to-methionine substitution. Valine 160-166 catechol-O-methyltransferase Homo sapiens 11-15 28262436-5 2017 RESULTS: The interaction between the Val/Val COMT genotype and a positive history of obstetric complications plus low parental socioeconomic status was significantly associated with poorer early adjustment. Valine 37-40 catechol-O-methyltransferase Homo sapiens 45-49 28640434-7 2017 RESULTS: There was a significant U-shaped association between COMT genotype and 6-m walk time: those with higher (Val/Val) and lower (Met/Met) dopamine slowed more over 10 years (0.22 +- 0.02 seconds per visit and 0.23 +- 0.02 seconds per visit, respectively) than those with the intermediate (Met/Val) dopamine (0.20 +- 0.02 seconds per visit) (P = .005). Valine 114-117 catechol-O-methyltransferase Homo sapiens 62-66 28640434-7 2017 RESULTS: There was a significant U-shaped association between COMT genotype and 6-m walk time: those with higher (Val/Val) and lower (Met/Met) dopamine slowed more over 10 years (0.22 +- 0.02 seconds per visit and 0.23 +- 0.02 seconds per visit, respectively) than those with the intermediate (Met/Val) dopamine (0.20 +- 0.02 seconds per visit) (P = .005). Valine 118-121 catechol-O-methyltransferase Homo sapiens 62-66 26864886-7 2017 Taking into account the catechol-O-methyltransferase (COMT) genotype, the best predictor of (prodromal) psychosis was the early adolescence academic domain score, which yielded higher sensitivity and specificity in the subgroup of youth with 22q11DS and the high-activity (valine) allele. Valine 273-279 catechol-O-methyltransferase Homo sapiens 24-52 27458023-2 2017 In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity. Valine 201-207 catechol-O-methyltransferase Homo sapiens 179-183 27458023-2 2017 In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity. Valine 209-212 catechol-O-methyltransferase Homo sapiens 179-183 26576742-8 2017 This reduced GMV was modulated by COMT polymorphism; Met-carriers exhibited smaller striatal GMV than the Val/Val genotype. Valine 106-109 catechol-O-methyltransferase Homo sapiens 34-38 26576742-8 2017 This reduced GMV was modulated by COMT polymorphism; Met-carriers exhibited smaller striatal GMV than the Val/Val genotype. Valine 110-113 catechol-O-methyltransferase Homo sapiens 34-38 26864886-7 2017 Taking into account the catechol-O-methyltransferase (COMT) genotype, the best predictor of (prodromal) psychosis was the early adolescence academic domain score, which yielded higher sensitivity and specificity in the subgroup of youth with 22q11DS and the high-activity (valine) allele. Valine 273-279 catechol-O-methyltransferase Homo sapiens 54-58 27027462-6 2016 Similarly, the duration was increased in individuals with the COMT Val/Val alleles compared with Val/Met and Met/Met (285 +- 37, 137 +- 25, and 63 +- 15 minutes, respectively; Logrank = 14.4, P = 0.0021). Valine 67-70 catechol-O-methyltransferase Homo sapiens 62-66 27091610-6 2016 RESULTS: Multivariate regression shrinkage analyses, adjusted for age, education, treatment type, time since treatment completion, and tumor location, indicated a significant association between the COMT SNP rs4680 (Val158Met) and memory with lower scores in delayed recall (P < .01) among homozygotes (valine/valine). Valine 306-312 catechol-O-methyltransferase Homo sapiens 199-203 27091610-6 2016 RESULTS: Multivariate regression shrinkage analyses, adjusted for age, education, treatment type, time since treatment completion, and tumor location, indicated a significant association between the COMT SNP rs4680 (Val158Met) and memory with lower scores in delayed recall (P < .01) among homozygotes (valine/valine). Valine 313-319 catechol-O-methyltransferase Homo sapiens 199-203 26996573-8 2016 CONCLUSION: These results indicate that the high-activity Val allele of the COMT Val158Met polymorphism is associated with increased alexithymic traits in patients with OCD. Valine 58-61 catechol-O-methyltransferase Homo sapiens 76-80 27021555-3 2016 The high activity COMT val isoform is associated with lower synaptic dopamine levels. Valine 23-26 catechol-O-methyltransferase Homo sapiens 18-22 26251232-5 2015 Specifically, the Valine variant of the COMT Val158Met polymorphism, which confers more rather than less efficient catabolism of catecholamines is associated with higher executive function abilities at child ages 48 and 60 months and with faster growth of executive function for children experiencing early adversity, as indexed by cumulative risk factors in the home at child ages 7, 15, 24, and 36 months. Valine 18-24 catechol-O-methyltransferase Homo sapiens 40-44 26973509-6 2016 Further, PP moderated the effects of COMT on 15-years EM trajectories, resulting in greater decline in Val carriers, even after accounting for the confounding effects of sex, education, cardiovascular diseases (diabetes, stroke, and hypertension), and chronological age, controlled for practice gains. Valine 103-106 catechol-O-methyltransferase Homo sapiens 37-41 27143897-0 2016 White matter alterations related to attention-deficit hyperactivity disorder and COMT val(158)met polymorphism: children with valine homozygote attention-deficit hyperactivity disorder have altered white matter connectivity in the right cingulum (cingulate gyrus). Valine 126-132 catechol-O-methyltransferase Homo sapiens 81-85 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 168-171 catechol-O-methyltransferase Homo sapiens 4-32 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 168-171 catechol-O-methyltransferase Homo sapiens 34-38 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 168-171 catechol-O-methyltransferase Homo sapiens 120-124 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 173-179 catechol-O-methyltransferase Homo sapiens 4-32 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 173-179 catechol-O-methyltransferase Homo sapiens 34-38 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Valine 173-179 catechol-O-methyltransferase Homo sapiens 120-124 25640985-2 2015 The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine (Val)-to-methionine (Met) substitution at codon 108/158. Valine 91-97 catechol-O-methyltransferase Homo sapiens 67-71 25640985-2 2015 The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine (Val)-to-methionine (Met) substitution at codon 108/158. Valine 99-102 catechol-O-methyltransferase Homo sapiens 67-71 25753458-2 2015 Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMT(HH)), intermediate (Val/Met, COMT(HL)) and low metabolizers (Met/Met, COMT(LL)). Valine 88-91 catechol-O-methyltransferase Homo sapiens 77-81 26555332-1 2015 AIM: Catechol-O-methyltransferase (COMT) is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. Valine 103-106 catechol-O-methyltransferase Homo sapiens 5-33 26555332-1 2015 AIM: Catechol-O-methyltransferase (COMT) is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. Valine 103-106 catechol-O-methyltransferase Homo sapiens 35-39 26555332-1 2015 AIM: Catechol-O-methyltransferase (COMT) is one of the major degradative pathways of dopamine and COMT Val/Met polymorphisms are associated with the enzyme activity, which is related to dopamine involvement in the nicotine addiction process. Valine 103-106 catechol-O-methyltransferase Homo sapiens 98-102 26489634-3 2015 This study aimed to examine the association of the genotypes of ABCB1 C3435T, OPRM1 A118G and COMT V108/158M (valine 108/158 methionine) with pain perception in cancer patients. Valine 110-116 catechol-O-methyltransferase Homo sapiens 94-98 26253436-2 2015 An association was found between the Valine (Val) 108/158Methionine (Met) COMT polymorphism (rs4680) and major depressive disorder (MDD). Valine 37-43 catechol-O-methyltransferase Homo sapiens 74-78 26253436-2 2015 An association was found between the Valine (Val) 108/158Methionine (Met) COMT polymorphism (rs4680) and major depressive disorder (MDD). Valine 37-40 catechol-O-methyltransferase Homo sapiens 74-78 25930952-7 2015 CONCLUSION: These are the first data from a randomized controlled trial indicating significant interactions of COMT polymorphism and behavioral therapy condition on treatment outcome, where Val carriers appeared to respond particularly well to computerized CBT. Valine 190-193 catechol-O-methyltransferase Homo sapiens 111-115 26376054-7 2015 Scores of carriers of this COMT/DRD3 combination significantly differed from all DRD3 Gly/Gly combinations (p < 0.05), from COMT Val/Met DRD3 Ser/Gly (p = 0.02), and from COMT Val/Val DRD3 Ser/Ser (p = 0.01) in patients. Valine 132-135 catechol-O-methyltransferase Homo sapiens 27-31 26376054-7 2015 Scores of carriers of this COMT/DRD3 combination significantly differed from all DRD3 Gly/Gly combinations (p < 0.05), from COMT Val/Met DRD3 Ser/Gly (p = 0.02), and from COMT Val/Val DRD3 Ser/Ser (p = 0.01) in patients. Valine 132-135 catechol-O-methyltransferase Homo sapiens 127-131 26376054-7 2015 Scores of carriers of this COMT/DRD3 combination significantly differed from all DRD3 Gly/Gly combinations (p < 0.05), from COMT Val/Met DRD3 Ser/Gly (p = 0.02), and from COMT Val/Val DRD3 Ser/Ser (p = 0.01) in patients. Valine 132-135 catechol-O-methyltransferase Homo sapiens 127-131 25466290-3 2015 The activity of COMT enzyme is genetically polymorphic due to a guanine-to-adenine transition at codon 158, resulting in a valine (Val) to methionine (Met) substitution. Valine 123-129 catechol-O-methyltransferase Homo sapiens 16-20 25466290-3 2015 The activity of COMT enzyme is genetically polymorphic due to a guanine-to-adenine transition at codon 158, resulting in a valine (Val) to methionine (Met) substitution. Valine 131-134 catechol-O-methyltransferase Homo sapiens 16-20 25466290-4 2015 Individuals homozygous for the Val allele show higher COMT activity, and lower dopaminergic signaling in prefrontal cortex (PFC) than subjects homozygous for the Met allele. Valine 31-34 catechol-O-methyltransferase Homo sapiens 54-58 25753458-2 2015 Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMT(HH)), intermediate (Val/Met, COMT(HL)) and low metabolizers (Met/Met, COMT(LL)). Valine 124-127 catechol-O-methyltransferase Homo sapiens 77-81 25753458-2 2015 Its activity is mainly determined by a single nucleotide polymorphism in the COMT gene (Val158Met, rs4680) separating high (Val/Val, COMT(HH)), intermediate (Val/Met, COMT(HL)) and low metabolizers (Met/Met, COMT(LL)). Valine 124-127 catechol-O-methyltransferase Homo sapiens 77-81 25744938-7 2015 Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. Valine 81-84 catechol-O-methyltransferase Homo sapiens 76-80 24819065-0 2015 Lower baseline performance but greater plasticity of working memory for carriers of the val allele of the COMT Val158Met polymorphism. Valine 88-91 catechol-O-methyltransferase Homo sapiens 106-110 25253063-6 2015 The functional COMT Val158Met polymorphism of the COMT gene represents two coding variants, valine and methionine. Valine 92-98 catechol-O-methyltransferase Homo sapiens 15-19 25253063-6 2015 The functional COMT Val158Met polymorphism of the COMT gene represents two coding variants, valine and methionine. Valine 92-98 catechol-O-methyltransferase Homo sapiens 50-54 25185591-10 2014 In the 6- to 48-hour postsurgery period, there was significantly higher opioid consumption in the high-activity homozygotes Val/Val than in the homozygous Met/Met group for COMT rs4680 (0-6 h: P = 0.005; 0-12 h: P = 0.015; 0-24 h: P = 0.015; and 0-48 h: P = 0.023). Valine 124-127 catechol-O-methyltransferase Homo sapiens 173-177 26630958-5 2015 The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. Valine 61-67 catechol-O-methyltransferase Homo sapiens 44-48 26630958-5 2015 The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. Valine 61-64 catechol-O-methyltransferase Homo sapiens 44-48 25185591-10 2014 In the 6- to 48-hour postsurgery period, there was significantly higher opioid consumption in the high-activity homozygotes Val/Val than in the homozygous Met/Met group for COMT rs4680 (0-6 h: P = 0.005; 0-12 h: P = 0.015; 0-24 h: P = 0.015; and 0-48 h: P = 0.023). Valine 128-131 catechol-O-methyltransferase Homo sapiens 173-177 25035343-4 2014 APPROACH AND RESULTS: We examined COMT polymorphism rs4680 (MAF [minor allele frequency], 0.47), encoding a nonsynonymous methionine-to-valine substitution, in the Women"s Genome Health Study (WGHS), a large population-based cohort of women with randomized allocation to aspirin or vitamin E when compared with placebo and 10-year follow-up. Valine 136-142 catechol-O-methyltransferase Homo sapiens 34-38 25218601-6 2014 Among individuals with the COMT val allele, those with 2 copies of the ESR1 rs3020377 minor A allele exhibit reduced COMT activity, increased bodily pain, and poorer self-reported health. Valine 32-35 catechol-O-methyltransferase Homo sapiens 27-31 25218601-6 2014 Among individuals with the COMT val allele, those with 2 copies of the ESR1 rs3020377 minor A allele exhibit reduced COMT activity, increased bodily pain, and poorer self-reported health. Valine 32-35 catechol-O-methyltransferase Homo sapiens 117-121 24972245-8 2014 The homozygous Val Met substitution in the SNP rs4680 resulted in significantly decreased COMT activity. Valine 15-18 catechol-O-methyltransferase Homo sapiens 90-94 24888672-2 2014 A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Valine 13-19 catechol-O-methyltransferase Homo sapiens 66-94 24888672-2 2014 A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Valine 13-19 catechol-O-methyltransferase Homo sapiens 96-100 23311613-8 2014 The results showed that the COMT polymorphism influenced the volume of the bilateral ventral caudate nucleus in both groups, but in an opposite direction: more copies of val allele led to lesser volume in chronic cannabis users and more volume in controls. Valine 170-173 catechol-O-methyltransferase Homo sapiens 28-32 23992923-8 2014 Haplotype analysis revealed clear phenotypic differences between various Val-containing haplotypes on COMT-3" untranslated region extended mRNA, soluble COMT and membrane-bound proteins, and enzyme activity. Valine 73-76 catechol-O-methyltransferase Homo sapiens 102-106 24443099-5 2014 The purpose of this study was to assess whether a functional polymorphism, Val(108/158)Met in the gene for catechol-O-methyltransferase (COMT), is associated with susceptibility to polydipsia using a Japanese sample of SCZ. Valine 75-78 catechol-O-methyltransferase Homo sapiens 107-135 24443099-5 2014 The purpose of this study was to assess whether a functional polymorphism, Val(108/158)Met in the gene for catechol-O-methyltransferase (COMT), is associated with susceptibility to polydipsia using a Japanese sample of SCZ. Valine 75-78 catechol-O-methyltransferase Homo sapiens 137-141 24956006-2 2014 Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. Valine 42-48 catechol-O-methyltransferase Homo sapiens 93-121 24956006-2 2014 Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. Valine 42-48 catechol-O-methyltransferase Homo sapiens 123-127 24629213-6 2014 RESULTS: We found an independent association of CYP1A1 (Val) and CYP17 (A1) with BC risk.Furthermore, an increased BC risk was observed for women with high serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) and carriers of at least: one CYP1A1 variant Val allele; one variant COMT Met allele; or the common CYP17 A1 allele. Valine 56-59 catechol-O-methyltransferase Homo sapiens 308-312 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Valine 43-46 catechol-O-methyltransferase Homo sapiens 133-137 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 19-22 catechol-O-methyltransferase Homo sapiens 12-16 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 148-151 catechol-O-methyltransferase Homo sapiens 12-16 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 148-151 catechol-O-methyltransferase Homo sapiens 12-16 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 148-151 catechol-O-methyltransferase Homo sapiens 12-16 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 148-151 catechol-O-methyltransferase Homo sapiens 12-16 24342707-8 2014 Among them, COMT p.Val158Met polymorphism displayed a significant linear "genotype effect" (P = .033), with the Met/Met (mean = 17.8 +- 4.8 mA) and Val/Val (mean = 21.4 +- 4.6 mA) subgroups at the opposite ends of the nociceptive flexion reflex threshold (Met/Met vs Val/Val P = .015) and the Val/Met subgroup (mean = 19 +- 4.9 mA) in between (Val/Met vs Val/Val P = .041). Valine 148-151 catechol-O-methyltransferase Homo sapiens 12-16 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Valine 229-235 catechol-O-methyltransferase Homo sapiens 39-43 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Valine 229-232 catechol-O-methyltransferase Homo sapiens 39-43 23956130-2 2014 Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and better performance on frontally mediated tasks compared to the Val allele. Valine 213-216 catechol-O-methyltransferase Homo sapiens 0-28 23956130-2 2014 Catechol-O-methyltransferase (COMT) metabolizes dopamine in the prefrontal cortex, with the Met allele resulting in greater dopamine availability and better performance on frontally mediated tasks compared to the Val allele. Valine 213-216 catechol-O-methyltransferase Homo sapiens 30-34 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Valine 43-49 catechol-O-methyltransferase Homo sapiens 103-131 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Valine 43-49 catechol-O-methyltransferase Homo sapiens 133-137 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Valine 43-46 catechol-O-methyltransferase Homo sapiens 103-131 24035893-2 2013 A functional single nucleotide polymorphism (rs4680 SNP; G to A) in the COMT coding region causes Val158Met amino acid substitution in the corresponding protein, with Val allele exhibiting markedly 3- to 4-fold higher than Met in enzyme activity. Valine 98-101 catechol-O-methyltransferase Homo sapiens 72-76 23618651-9 2013 Specifically, further FA reduction was evident in MDD patients with the valine homozygote group of the COMT gene. Valine 72-78 catechol-O-methyltransferase Homo sapiens 103-107 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 117-123 catechol-O-methyltransferase Homo sapiens 0-28 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 117-123 catechol-O-methyltransferase Homo sapiens 30-34 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 242-245 catechol-O-methyltransferase Homo sapiens 0-28 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 242-245 catechol-O-methyltransferase Homo sapiens 30-34 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 246-249 catechol-O-methyltransferase Homo sapiens 0-28 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Valine 246-249 catechol-O-methyltransferase Homo sapiens 30-34 23773341-6 2013 Indeed, in an exploratory cohort of migraine patients without aura (n = 75), homozygous carriers of the COMT 158Met allele were found at increased risk to be poor responders to frovatriptan when compared to homozygous patients for the Val allele (OR: 5.20, 95% CI: 1.25-21.57, P = .023). Valine 235-238 catechol-O-methyltransferase Homo sapiens 104-108 24039968-2 2013 Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). Valine 177-183 catechol-O-methyltransferase Homo sapiens 271-275 24039968-2 2013 Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). Valine 177-180 catechol-O-methyltransferase Homo sapiens 271-275 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Valine 139-145 catechol-O-methyltransferase Homo sapiens 55-83 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Valine 139-145 catechol-O-methyltransferase Homo sapiens 85-89 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Valine 147-150 catechol-O-methyltransferase Homo sapiens 55-83 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Valine 147-150 catechol-O-methyltransferase Homo sapiens 85-89 23408064-2 2013 The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. Valine 4-7 catechol-O-methyltransferase Homo sapiens 34-38 23408064-2 2013 The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. Valine 93-96 catechol-O-methyltransferase Homo sapiens 34-38 23408064-2 2013 The Val158Met polymorphism in the COMT gene (rs4680) causes a trimodal distribution of high (Val/Val), intermediate (Val/Met) and low (Met/Met) enzyme activity. Valine 93-96 catechol-O-methyltransferase Homo sapiens 34-38 23408064-11 2013 Thus, the Val158Met COMT polymorphism is not associated with PD in the Caucasian population but acts as a modifier of the AAO in PD with a sexual dimorphism: the Val allele is associated with a younger AAO in men with idiopathic PD. Valine 10-13 catechol-O-methyltransferase Homo sapiens 20-24 22689336-3 2013 RESULTS: The literature on inverted-U effects in the PFC suggests that catechol-O-methyltransferase (COMT) Met versus Val polymorphisms may predict excess dopaminergic effects, including headache and introversion in Met/Met subjects, but therapeutic effects in Val/Val subjects, while dopamine transporter polymorphisms may predict motor side effects. Valine 261-264 catechol-O-methyltransferase Homo sapiens 71-99 22689336-3 2013 RESULTS: The literature on inverted-U effects in the PFC suggests that catechol-O-methyltransferase (COMT) Met versus Val polymorphisms may predict excess dopaminergic effects, including headache and introversion in Met/Met subjects, but therapeutic effects in Val/Val subjects, while dopamine transporter polymorphisms may predict motor side effects. Valine 261-264 catechol-O-methyltransferase Homo sapiens 101-105 22689336-3 2013 RESULTS: The literature on inverted-U effects in the PFC suggests that catechol-O-methyltransferase (COMT) Met versus Val polymorphisms may predict excess dopaminergic effects, including headache and introversion in Met/Met subjects, but therapeutic effects in Val/Val subjects, while dopamine transporter polymorphisms may predict motor side effects. Valine 261-264 catechol-O-methyltransferase Homo sapiens 71-99 22689336-3 2013 RESULTS: The literature on inverted-U effects in the PFC suggests that catechol-O-methyltransferase (COMT) Met versus Val polymorphisms may predict excess dopaminergic effects, including headache and introversion in Met/Met subjects, but therapeutic effects in Val/Val subjects, while dopamine transporter polymorphisms may predict motor side effects. Valine 261-264 catechol-O-methyltransferase Homo sapiens 101-105 23421957-5 2013 CONCLUSIONS: The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load. Valine 126-129 catechol-O-methyltransferase Homo sapiens 121-125 22901597-1 2013 BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism (rs4680) influences enzyme activity with valine (Val) allele associated with higher enzymatic activity. Valine 122-128 catechol-O-methyltransferase Homo sapiens 16-44 22901597-1 2013 BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism (rs4680) influences enzyme activity with valine (Val) allele associated with higher enzymatic activity. Valine 122-128 catechol-O-methyltransferase Homo sapiens 46-50 22901597-1 2013 BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism (rs4680) influences enzyme activity with valine (Val) allele associated with higher enzymatic activity. Valine 52-55 catechol-O-methyltransferase Homo sapiens 16-44 22901597-1 2013 BACKGROUND: The catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism (rs4680) influences enzyme activity with valine (Val) allele associated with higher enzymatic activity. Valine 52-55 catechol-O-methyltransferase Homo sapiens 46-50 21530215-10 2012 Carriers of the COMT Val158Met*Val allele presented higher intake of LDF when compared with Met/Met homozygotes (P=.008). Valine 21-24 catechol-O-methyltransferase Homo sapiens 16-20 23278923-4 2013 In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. Valine 121-127 catechol-O-methyltransferase Homo sapiens 33-37 23278923-4 2013 In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. Valine 38-41 catechol-O-methyltransferase Homo sapiens 33-37 21898113-5 2012 After amplifying Val158Met polymorphisms by polymerase chain reaction, COMT genotype was divided into Val/Val, valine/methionine (Val/Met), or Met/Met. Valine 102-105 catechol-O-methyltransferase Homo sapiens 71-75 21898113-5 2012 After amplifying Val158Met polymorphisms by polymerase chain reaction, COMT genotype was divided into Val/Val, valine/methionine (Val/Met), or Met/Met. Valine 111-117 catechol-O-methyltransferase Homo sapiens 71-75 21898113-5 2012 After amplifying Val158Met polymorphisms by polymerase chain reaction, COMT genotype was divided into Val/Val, valine/methionine (Val/Met), or Met/Met. Valine 102-105 catechol-O-methyltransferase Homo sapiens 71-75 22133998-9 2012 For HR, we found differences associated with COMT, i.e. children carrying at least one met allele showed lower mean HR increase and slower HR recovery in response to the stressor compared to those with two val alleles (p<.001) as well as a significant decrease in heart rate variability (p<.05). Valine 206-209 catechol-O-methyltransferase Homo sapiens 45-49 22695756-11 2012 We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). Valine 99-102 catechol-O-methyltransferase Homo sapiens 94-98 22695756-11 2012 We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). Valine 103-106 catechol-O-methyltransferase Homo sapiens 94-98 22573634-3 2012 RESULTS: Whole-brain voxel-wise regression analyses revealed that COMT Val(158)Met Val allele dosage, known to produce a dose-dependent decrease in synaptic dopamine (DA) availability, correlated with decreased gray matter in the region of the ventral tegmental area (VTA), ventromedial prefrontal cortex, bilateral dorsal midinsula, left dorsolateral prefrontal cortex, and right ventral striatum. Valine 71-74 catechol-O-methyltransferase Homo sapiens 66-70 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 217-220 catechol-O-methyltransferase Homo sapiens 14-18 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 217-220 catechol-O-methyltransferase Homo sapiens 157-161 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 217-220 catechol-O-methyltransferase Homo sapiens 157-161 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 290-293 catechol-O-methyltransferase Homo sapiens 14-18 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 290-293 catechol-O-methyltransferase Homo sapiens 157-161 22586360-7 2012 We found that COMT significantly affected DD and that this effect was mediated by baseline activation level in the left dorsal prefrontal cortex (DPFC): (i) COMT had a significant effect on DD such that the number of Val alleles was positively correlated with steeper DD (higher numbers of Val alleles means greater COMT activity and thus lower dopamine levels). Valine 290-293 catechol-O-methyltransferase Homo sapiens 157-161 22832813-5 2012 However, the effect was predominantly present in val/val homozygotes of the functional val158met polymorphism of the catechol O-methyltransferase (COMT) enzyme and in short-allele carriers of the serotonin-transporter length 5-HTTLPR polymorphism. Valine 49-52 catechol-O-methyltransferase Homo sapiens 117-145 22832813-5 2012 However, the effect was predominantly present in val/val homozygotes of the functional val158met polymorphism of the catechol O-methyltransferase (COMT) enzyme and in short-allele carriers of the serotonin-transporter length 5-HTTLPR polymorphism. Valine 49-52 catechol-O-methyltransferase Homo sapiens 147-151 22049425-3 2011 Male human participants (n = 169) were genotyped for the catechol-O-methyltransferase (COMT) Val158Met polymorphism, associated with low (Val) and medium (Met) PFC DA levels. Valine 93-96 catechol-O-methyltransferase Homo sapiens 57-85 22890094-2 2012 A single nucleotide polymorphism (rs4680; G to A) in the COMT coding region causes Val158Met aminoacid substitution in the corresponding protein, with Val allele exhibiting a 3- to 4-fold increase in enzyme activity compared to Met. Valine 83-86 catechol-O-methyltransferase Homo sapiens 57-61 21999147-3 2011 A common Val->Met polymorphism (rs4680) in the COMT gene, associated with increased prefrontal dopamine catabolism, impairs prefrontal cognition and might increase risk for schizophrenia. Valine 9-12 catechol-O-methyltransferase Homo sapiens 50-54 22049425-3 2011 Male human participants (n = 169) were genotyped for the catechol-O-methyltransferase (COMT) Val158Met polymorphism, associated with low (Val) and medium (Met) PFC DA levels. Valine 93-96 catechol-O-methyltransferase Homo sapiens 87-91 21486391-2 2011 It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. Valine 118-124 catechol-O-methyltransferase Homo sapiens 168-172 21620981-3 2011 We sought to address these issues by relating a functional Val Met polymorphism within the gene encoding catechol-o-methyltransferase (COMT)-a key enzymatic regulator of cortical dopamine levels-to longitudinal structural neuroimaging measures of cortical gray matter thickness. Valine 59-62 catechol-O-methyltransferase Homo sapiens 105-133 21620981-3 2011 We sought to address these issues by relating a functional Val Met polymorphism within the gene encoding catechol-o-methyltransferase (COMT)-a key enzymatic regulator of cortical dopamine levels-to longitudinal structural neuroimaging measures of cortical gray matter thickness. Valine 59-62 catechol-O-methyltransferase Homo sapiens 135-139 21514925-8 2011 Main effects of COMT genotype were also observed in the IPS, with greater gray matter volumes bilaterally and greater right IPS activation in the Val/Val group compared with the Met carriers. Valine 146-149 catechol-O-methyltransferase Homo sapiens 16-20 21514925-8 2011 Main effects of COMT genotype were also observed in the IPS, with greater gray matter volumes bilaterally and greater right IPS activation in the Val/Val group compared with the Met carriers. Valine 150-153 catechol-O-methyltransferase Homo sapiens 16-20 21486391-2 2011 It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. Valine 126-129 catechol-O-methyltransferase Homo sapiens 168-172 21215384-3 2011 Therefore, we projected that healthy control subjects with risk genotypes for both DAOA M24 (T/T) and COMT Val158Met (Val/Val) would produce prefrontal inefficiency, a critical physiological marker of the dorsolateral prefrontal cortex (DLPFC) in schizophrenic patients influenced by both familial and heritable factors. Valine 107-110 catechol-O-methyltransferase Homo sapiens 102-106 21215384-3 2011 Therefore, we projected that healthy control subjects with risk genotypes for both DAOA M24 (T/T) and COMT Val158Met (Val/Val) would produce prefrontal inefficiency, a critical physiological marker of the dorsolateral prefrontal cortex (DLPFC) in schizophrenic patients influenced by both familial and heritable factors. Valine 118-121 catechol-O-methyltransferase Homo sapiens 102-106 21543598-5 2011 The relationship of methylation of the COMT Val(158) allele with stress, gene expression, WM performance, and related brain activity suggests that stress-related methylation is associated with silencing of the gene, which partially compensates the physiological role of the high-activity Val allele in prefrontal cognition and activity. Valine 44-47 catechol-O-methyltransferase Homo sapiens 39-43 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Valine 79-85 catechol-O-methyltransferase Homo sapiens 13-41 21575337-1 2011 OBJECTIVE: To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children. Valine 165-171 catechol-O-methyltransferase Homo sapiens 75-103 21575337-1 2011 OBJECTIVE: To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children. Valine 165-171 catechol-O-methyltransferase Homo sapiens 105-109 21280081-2 2011 The COMT Val158Met polymorphism is equally distributed in PD patients and modulates COMT activity, which can be high (Val/Val, COMT(HH) ), intermediate (Val/Met, COMT(HL) ), or low (Met/Met, COMT(LL) ). Valine 9-12 catechol-O-methyltransferase Homo sapiens 4-8 21280081-2 2011 The COMT Val158Met polymorphism is equally distributed in PD patients and modulates COMT activity, which can be high (Val/Val, COMT(HH) ), intermediate (Val/Met, COMT(HL) ), or low (Met/Met, COMT(LL) ). Valine 9-12 catechol-O-methyltransferase Homo sapiens 84-88 21280081-2 2011 The COMT Val158Met polymorphism is equally distributed in PD patients and modulates COMT activity, which can be high (Val/Val, COMT(HH) ), intermediate (Val/Met, COMT(HL) ), or low (Met/Met, COMT(LL) ). Valine 9-12 catechol-O-methyltransferase Homo sapiens 84-88 21425136-2 2011 The current study examined modification of this risk by catechol-O-methyltransferase (COMT) genotype based on evidence in adult populations that the presence of a Val allele is associated with poorer cognitive performance. Valine 163-166 catechol-O-methyltransferase Homo sapiens 56-84 21425136-2 2011 The current study examined modification of this risk by catechol-O-methyltransferase (COMT) genotype based on evidence in adult populations that the presence of a Val allele is associated with poorer cognitive performance. Valine 163-166 catechol-O-methyltransferase Homo sapiens 86-90 21425136-6 2011 Moreover, COMT-Val+ carriers treated with chemotherapy performed more poorly on tests of attention relative to HC group members who were also Val+ carriers. Valine 15-19 catechol-O-methyltransferase Homo sapiens 10-14 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 81-87 catechol-O-methyltransferase Homo sapiens 29-33 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 81-87 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 81-87 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 34-37 catechol-O-methyltransferase Homo sapiens 29-33 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 34-37 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Valine 34-37 catechol-O-methyltransferase Homo sapiens 57-61 20667170-1 2011 BACKGROUND: The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. Valine 70-76 catechol-O-methyltransferase Homo sapiens 34-62 20667170-1 2011 BACKGROUND: The Met allele of the catechol-O-methyltransferase (COMT) valine-to-methionine (Val158Met) polymorphism is known to affect dopamine-dependent affective regulation within amygdala-prefrontal cortical (PFC) networks. Valine 70-76 catechol-O-methyltransferase Homo sapiens 64-68 21130573-2 2011 Participants were genotyped for the val(158)met single nucleotide polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene. Valine 36-39 catechol-O-methyltransferase Homo sapiens 95-123 21130573-2 2011 Participants were genotyped for the val(158)met single nucleotide polymorphism (rs4680) in the catechol-O-methyltransferase (COMT) gene. Valine 36-39 catechol-O-methyltransferase Homo sapiens 125-129 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Valine 79-85 catechol-O-methyltransferase Homo sapiens 43-47 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Valine 48-51 catechol-O-methyltransferase Homo sapiens 13-41 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Valine 48-51 catechol-O-methyltransferase Homo sapiens 43-47 19417742-5 2010 Strong and opposing effects were found for executive cognition paradigms (favoring Met allele carriers) and emotional paradigms (favoring Val), providing meta-analytical evidence for a neural substrate for the pleiotropic behavioral effects of COMT genetic variation and validating the use of intermediate phenotypes as a method to bridge between genes and behavior. Valine 138-141 catechol-O-methyltransferase Homo sapiens 244-248 20431430-7 2010 T/T carriers of HTR2A T102C polymorphism, that also had Met/Met genotype of COMT Val158Met single nucleotide polymorphism, scored significantly higher on impulsiveness than Val allele carriers (P=0.005). Valine 81-84 catechol-O-methyltransferase Homo sapiens 76-80 21110842-8 2010 Furthermore patients carrying a COMT val-allele tend to report more anxiety and more depression symptoms as compared to those with the met/met genotype. Valine 37-40 catechol-O-methyltransferase Homo sapiens 32-36 21304229-2 2011 The catechol-O-methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 43-46 catechol-O-methyltransferase Homo sapiens 4-32 21304229-2 2011 The catechol-O-methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 43-46 catechol-O-methyltransferase Homo sapiens 34-38 21304229-2 2011 The catechol-O-methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 43-46 catechol-O-methyltransferase Homo sapiens 72-76 21304229-2 2011 The catechol-O-methyltransferase (COMT) 158Val/Met polymorphism affects COMT activity; that is, the alleles encoding Val and Met are associated with relatively high and relatively low COMT activity, respectively. Valine 43-46 catechol-O-methyltransferase Homo sapiens 72-76 20836853-3 2010 A mechanistic account of the COMT Val158Met effect associates the Met allele with increased tonic dopamine transmission underlying maintenance of relevant information, and the Val allele with increased phasic dopamine transmission underlying the flexibility of updating new information. Valine 34-37 catechol-O-methyltransferase Homo sapiens 29-33 20414144-12 2010 CONCLUSION: The results of this study extend earlier findings with the COMT genotypes to additional measures of cognition, and suggest that the presence of the val allele is associated with poorer performance and greater improvement with a stimulant drug. Valine 160-163 catechol-O-methyltransferase Homo sapiens 71-75 20038544-2 2010 Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP -521 polymorphism of the dopamine D4 receptor. Valine 187-193 catechol-O-methyltransferase Homo sapiens 223-251 20038544-4 2010 These activations were modulated by the COMT polymorphism with greater effects for valine/valine participants but not by the D4 receptor polymorphism. Valine 83-89 catechol-O-methyltransferase Homo sapiens 40-44 20038544-4 2010 These activations were modulated by the COMT polymorphism with greater effects for valine/valine participants but not by the D4 receptor polymorphism. Valine 90-96 catechol-O-methyltransferase Homo sapiens 40-44 20509070-1 2010 Previous studies implicate involvement of dopaminergic systems in hypnotizability and report association with the COMT Val(158)Met single nucleotide polymorphism (SNP, rs4680) demonstrating the Val/Met heterozygotes as the most hypnotizable group using the Stanford Hypnotic Susceptibility Scale. Valine 119-122 catechol-O-methyltransferase Homo sapiens 114-118 18755526-1 2010 We investigated whether the val(158)met functional polymorphism of catechol-o-methyltransferase influenced age-related changes in grey matter density and volume, both in healthy individuals (n=80, ages 18-79) and those with Parkinson"s disease (n=50). Valine 28-31 catechol-O-methyltransferase Homo sapiens 67-95 20069120-5 2010 A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. Valine 170-173 catechol-O-methyltransferase Homo sapiens 2-6 19892319-0 2010 Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia. Valine 29-35 catechol-O-methyltransferase Homo sapiens 0-28 19892319-1 2010 BACKGROUND: A valine(158)methionine (val(158)met) polymorphism in catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Valine 14-20 catechol-O-methyltransferase Homo sapiens 66-94 19892319-1 2010 BACKGROUND: A valine(158)methionine (val(158)met) polymorphism in catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Valine 14-20 catechol-O-methyltransferase Homo sapiens 96-100 19946713-2 2010 A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. Valine 95-101 catechol-O-methyltransferase Homo sapiens 169-173 19946713-2 2010 A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. Valine 34-37 catechol-O-methyltransferase Homo sapiens 169-173 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 102-108 catechol-O-methyltransferase Homo sapiens 4-32 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 102-108 catechol-O-methyltransferase Homo sapiens 34-38 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 102-108 catechol-O-methyltransferase Homo sapiens 156-160 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 40-43 catechol-O-methyltransferase Homo sapiens 4-32 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 40-43 catechol-O-methyltransferase Homo sapiens 34-38 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Valine 40-43 catechol-O-methyltransferase Homo sapiens 156-160 20069120-5 2010 A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. Valine 196-199 catechol-O-methyltransferase Homo sapiens 2-6 20069120-5 2010 A COMT x executive dysfunction interaction was found for number of sexual partners and insertive anal sex, significant for carriers of the Met/Met and to a lesser extent Val/Met genotypes but not Val/Val carriers. Valine 196-199 catechol-O-methyltransferase Homo sapiens 2-6 20074440-3 2009 The association between Val/Met polymorphism at the COMT gene was evaluated in FM disorder. Valine 24-27 catechol-O-methyltransferase Homo sapiens 52-56 19381707-1 2009 Variation in the val(158)met polymorphism of the COMT gene has been found to be associated with cognitive performance. Valine 17-20 catechol-O-methyltransferase Homo sapiens 49-53 19381707-6 2009 Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. Valine 167-170 catechol-O-methyltransferase Homo sapiens 186-190 19539269-0 2009 Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood. Valine 29-35 catechol-O-methyltransferase Homo sapiens 0-28 19539269-3 2009 Among these variations, those related to the dopaminergic system, particularly the valine(158)methionine polymorphism in catechol-O-methyltransferase (COMTval(158)met), have been implicated in modulating age-related changes in executive function. Valine 83-89 catechol-O-methyltransferase Homo sapiens 121-149 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 206-212 catechol-O-methyltransferase Homo sapiens 47-75 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 206-212 catechol-O-methyltransferase Homo sapiens 77-81 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 206-212 catechol-O-methyltransferase Homo sapiens 235-239 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 214-217 catechol-O-methyltransferase Homo sapiens 47-75 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 214-217 catechol-O-methyltransferase Homo sapiens 77-81 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Valine 214-217 catechol-O-methyltransferase Homo sapiens 235-239 19585392-1 2009 BACKGROUND: Associations between the well-known functional single nucleotide polymorphism Val (158)Met in the gene encoding catechol- O-methyltransferase (COMT) and cognitive do-mains affected in schizophrenia are inconsistent regarding directionality and specific impact and call for a more fundamental cognitive endophenotype. Valine 90-93 catechol-O-methyltransferase Homo sapiens 124-153 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Valine 105-111 catechol-O-methyltransferase Homo sapiens 69-97 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Valine 105-111 catechol-O-methyltransferase Homo sapiens 99-103 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Valine 105-108 catechol-O-methyltransferase Homo sapiens 69-97 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Valine 105-108 catechol-O-methyltransferase Homo sapiens 99-103 19251248-4 2009 Based on the phasic/tonic dopamine hypothesis, we expected increased brain responses to losses and gains in participants homozygous for the Val/Val variant of the COMT polymorphism (related to higher enzyme activity). Valine 140-143 catechol-O-methyltransferase Homo sapiens 163-167 19251248-4 2009 Based on the phasic/tonic dopamine hypothesis, we expected increased brain responses to losses and gains in participants homozygous for the Val/Val variant of the COMT polymorphism (related to higher enzyme activity). Valine 144-147 catechol-O-methyltransferase Homo sapiens 163-167 19251248-7 2009 CONCLUSIONS: The results demonstrate the role of the COMT Val/Met polymorphism in the processing of reward, consistent with theoretical explanations that suggest the possible role of dopamine in the MFN and beta power increase generation. Valine 58-61 catechol-O-methyltransferase Homo sapiens 53-57 19666577-6 2009 In this region, relatively increased activation was detected only when COMT Met-158/Met-158 subjects also carried the 9-repeat DAT allele, or when, reversely, Val-158/Val-158 subjects carried the 10/10-repeat genotype. Valine 159-162 catechol-O-methyltransferase Homo sapiens 71-75 19666577-6 2009 In this region, relatively increased activation was detected only when COMT Met-158/Met-158 subjects also carried the 9-repeat DAT allele, or when, reversely, Val-158/Val-158 subjects carried the 10/10-repeat genotype. Valine 167-170 catechol-O-methyltransferase Homo sapiens 71-75 19666577-7 2009 Also, there was a significant diagnosis x COMT x DAT nonadditive interaction in the right orbital gyrus (Z-score = 4.3; FWEp = 0.04), where, only within patients, greater activation was only associated with a 9-repeat allele and Val-158 conjunction, and with a 10-repeat and Met-158 conjunction (Z-score = 4.3; FWE p = 0.04). Valine 229-232 catechol-O-methyltransferase Homo sapiens 42-46 19605537-3 2009 A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Valine 13-19 catechol-O-methyltransferase Homo sapiens 68-96 19605537-3 2009 A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Valine 13-19 catechol-O-methyltransferase Homo sapiens 98-102 19585392-1 2009 BACKGROUND: Associations between the well-known functional single nucleotide polymorphism Val (158)Met in the gene encoding catechol- O-methyltransferase (COMT) and cognitive do-mains affected in schizophrenia are inconsistent regarding directionality and specific impact and call for a more fundamental cognitive endophenotype. Valine 90-93 catechol-O-methyltransferase Homo sapiens 155-159 19585392-6 2009 CONCLUSIONS: Our data suggest that allelic variation at the COMT Val (158)Met locus may influence signal discrimination capacity in schizophrenia and confirm that Val loading, probably due to decreased prefrontal dopamine availability, is associated with greater cognitive flexibility, which in turn may influence other cognitive measures that have been associated with COMT to date. Valine 65-68 catechol-O-methyltransferase Homo sapiens 60-64 19246329-3 2009 A common polymorphism with valine to methionine substitution alters COMT activity that results in higher enzyme activity in the valine variant. Valine 27-33 catechol-O-methyltransferase Homo sapiens 68-72 23034243-8 2009 The Val158Met polymorphism at the COMT gene was not associated with schizophrenia, although Val/Val homozygosity tended to be more frequent in the case group than in the control group (34% vs 27%; OR=1.39; 95% CI, 0.78-2.47). Valine 4-7 catechol-O-methyltransferase Homo sapiens 34-38 19037200-5 2009 A functional Val158Met polymorphism reduces COMT activity, and Val/Val homozygous individuals presumably have lower dopaminergic signaling in the prefrontal cortex than do Met/Met homozygotes. Valine 13-16 catechol-O-methyltransferase Homo sapiens 44-48 19246329-3 2009 A common polymorphism with valine to methionine substitution alters COMT activity that results in higher enzyme activity in the valine variant. Valine 128-134 catechol-O-methyltransferase Homo sapiens 68-72 18214865-5 2008 Our results did not indicate substantial involvement of these two VNTRs in ADHD, however, both the case-control and the pharmacogenetic analyses showed significant role of the high activity Val-allele of cathecol-O-methyltransferase (COMT) Val158Met polymorphism in our ADHD population. Valine 190-193 catechol-O-methyltransferase Homo sapiens 204-232 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Valine 198-204 catechol-O-methyltransferase Homo sapiens 0-29 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Valine 198-204 catechol-O-methyltransferase Homo sapiens 31-35 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Valine 198-204 catechol-O-methyltransferase Homo sapiens 119-123 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Valine 45-48 catechol-O-methyltransferase Homo sapiens 205-209 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Valine 132-135 catechol-O-methyltransferase Homo sapiens 205-209 18923401-1 2008 The COMT gene functional polymorphism val(158)met is one of the most intensively studied variants in psychiatric genetics. Valine 38-41 catechol-O-methyltransferase Homo sapiens 4-8 18214865-5 2008 Our results did not indicate substantial involvement of these two VNTRs in ADHD, however, both the case-control and the pharmacogenetic analyses showed significant role of the high activity Val-allele of cathecol-O-methyltransferase (COMT) Val158Met polymorphism in our ADHD population. Valine 190-193 catechol-O-methyltransferase Homo sapiens 234-238 19025226-5 2008 As a group, relatives of patients with schizophrenia who were homozygous for the val allele of the COMT polymorphism showed the highest elevations in self-reported social and physical anhedonia. Valine 81-84 catechol-O-methyltransferase Homo sapiens 99-103 18634888-2 2008 The common polymorphism val(158)met of catechol-O-methyltransferase (COMT) accounts for significant interindividual variations in dopamine (DA) degradation, although the direct effect of COMT on striatal DA might be limited. Valine 24-27 catechol-O-methyltransferase Homo sapiens 39-67 18634888-2 2008 The common polymorphism val(158)met of catechol-O-methyltransferase (COMT) accounts for significant interindividual variations in dopamine (DA) degradation, although the direct effect of COMT on striatal DA might be limited. Valine 24-27 catechol-O-methyltransferase Homo sapiens 69-73 18634888-2 2008 The common polymorphism val(158)met of catechol-O-methyltransferase (COMT) accounts for significant interindividual variations in dopamine (DA) degradation, although the direct effect of COMT on striatal DA might be limited. Valine 24-27 catechol-O-methyltransferase Homo sapiens 187-191 18287936-4 2008 Voxel-based morphometry showed that individuals who are homozygous for the Val-COMT allele had greater gray matter volume of the prefrontal cortex bilaterally, whereas Met-COMT carriers were associated with increased tissue volume of the hippocampus bilaterally. Valine 75-78 catechol-O-methyltransferase Homo sapiens 79-83 18474266-1 2008 The human gene for catechol O-methyltransferase has a common single-nucleotide polymorphism that results in substitution of methionine (M) for valine (V) 108 in the soluble form of the enzyme (s-COMT). Valine 143-149 catechol-O-methyltransferase Homo sapiens 19-47 18474266-1 2008 The human gene for catechol O-methyltransferase has a common single-nucleotide polymorphism that results in substitution of methionine (M) for valine (V) 108 in the soluble form of the enzyme (s-COMT). Valine 143-149 catechol-O-methyltransferase Homo sapiens 195-199 18213617-9 2008 Consistent with the hypothesis that Val158Met polymorphism (COMT gene) might account for individual differences on dopamine-dependent prefrontally related neurocognitive functions, the Letter-Number Sequencing task, which requires not only maintenance but also active manipulation of information seemed to be more sensitive to the disadvantageous Val/Val genotype in a large non-clinical sample. Valine 36-39 catechol-O-methyltransferase Homo sapiens 60-64 18213617-9 2008 Consistent with the hypothesis that Val158Met polymorphism (COMT gene) might account for individual differences on dopamine-dependent prefrontally related neurocognitive functions, the Letter-Number Sequencing task, which requires not only maintenance but also active manipulation of information seemed to be more sensitive to the disadvantageous Val/Val genotype in a large non-clinical sample. Valine 347-350 catechol-O-methyltransferase Homo sapiens 60-64 18703939-3 2008 We investigated the association between the COMT valine (Val) 108/158 methionine (Met) polymorphism and the response to treatment with methylphenidate (MPH) in children with ADHD. Valine 57-60 catechol-O-methyltransferase Homo sapiens 44-48 18486144-4 2008 Additionally, human COMT contains a common valine-methionine polymorphism at position 108. Valine 43-49 catechol-O-methyltransferase Homo sapiens 20-24 18545092-0 2008 Val/Met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men. Valine 0-3 catechol-O-methyltransferase Homo sapiens 28-32 17707347-12 2008 CONCLUSIONS: We extended earlier findings of a val(108/158)met effect on WM function, and suggest that combinations of alleles within COMT may modulate the val(108/158)met effect in a nonlinear manner. Valine 47-50 catechol-O-methyltransferase Homo sapiens 134-138 17850881-6 2008 Our data suggest that the COMT high-activity Val allele is associated with more obsessive-compulsive symptoms in young patients with schizophrenia. Valine 45-48 catechol-O-methyltransferase Homo sapiens 26-30 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-39 catechol-O-methyltransferase Homo sapiens 126-130 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-39 catechol-O-methyltransferase Homo sapiens 203-207 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-39 catechol-O-methyltransferase Homo sapiens 203-207 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-36 catechol-O-methyltransferase Homo sapiens 126-130 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-36 catechol-O-methyltransferase Homo sapiens 203-207 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Valine 33-36 catechol-O-methyltransferase Homo sapiens 203-207 18178571-2 2008 Some such deficits are known to relate to dysfunction in dopaminergic frontostriatal networks, and may be influenced by a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene. Valine 154-157 catechol-O-methyltransferase Homo sapiens 178-206 18178571-2 2008 Some such deficits are known to relate to dysfunction in dopaminergic frontostriatal networks, and may be influenced by a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene. Valine 154-157 catechol-O-methyltransferase Homo sapiens 208-212 17962094-3 2008 The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. Valine 9-12 catechol-O-methyltransferase Homo sapiens 4-8 18094258-8 2007 Additionally, participants homozygous for the COMT Val allele, with a thereby diminished prefrontal dopaminergic level, revealed increased prefrontal processing related to inhibitory functions, reflected in the enhanced stop-signal-related components N2 and P3a. Valine 51-54 catechol-O-methyltransferase Homo sapiens 46-50 18189003-12 2007 The COMT genotype affected Pe (but not ERN) magnitude; met/met homozygotes showed enhanced Pes to self-corrected errors, as compared with val carriers. Valine 138-141 catechol-O-methyltransferase Homo sapiens 4-8 17707347-12 2008 CONCLUSIONS: We extended earlier findings of a val(108/158)met effect on WM function, and suggest that combinations of alleles within COMT may modulate the val(108/158)met effect in a nonlinear manner. Valine 156-159 catechol-O-methyltransferase Homo sapiens 134-138 17599809-3 2007 We also examined associations with the valine (Val)158methionine (Met) single nucleotide polymorphism (SNP) of the gene for catechol-O-methyltransferase (COMT), an enzyme involved in estrogen metabolism and prefrontal cortical activation. Valine 39-45 catechol-O-methyltransferase Homo sapiens 124-152 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Valine 14-20 catechol-O-methyltransferase Homo sapiens 52-80 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Valine 14-20 catechol-O-methyltransferase Homo sapiens 172-176 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Valine 14-17 catechol-O-methyltransferase Homo sapiens 52-80 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Valine 14-17 catechol-O-methyltransferase Homo sapiens 172-176 17760745-3 2007 The enzymatic activity of COMT has been shown to be governed by a functional single-nucleotide polymorphism represented by a G-to-A transition at codon 158, that results in a valine to methionine substitution; this variant form is associated with an up to 4-fold decrease in enzymatic activity. Valine 175-181 catechol-O-methyltransferase Homo sapiens 26-30 17913879-5 2007 The Val/Met polymorphism of the COMT gene, associated with prefrontal cortical dopamine function, predicted participants" ability to rapidly adapt behavior on a trial-to-trial basis. Valine 4-7 catechol-O-methyltransferase Homo sapiens 32-36 17448448-3 2007 The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity. Valine 106-112 catechol-O-methyltransferase Homo sapiens 100-104 17448448-3 2007 The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity. Valine 106-109 catechol-O-methyltransferase Homo sapiens 70-98 17448448-3 2007 The role of prefrontal dopamine on P50 gating was investigated, using catechol-O-methyltransferase (COMT) valine (val)(158)methionine (met) polymorphism as a predictor of prefrontal dopamine activity. Valine 106-109 catechol-O-methyltransferase Homo sapiens 100-104 17448448-7 2007 CONCLUSIONS: Valine homozygous individuals are more likely to have gating deficits, supporting COMT as a genetic determinant of the P50 endophenotype, as well as a role for prefrontal dopamine in auditory filtering. Valine 13-19 catechol-O-methyltransferase Homo sapiens 95-99 17299513-8 2007 Our results suggest that high COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior. Valine 71-74 catechol-O-methyltransferase Homo sapiens 30-34 17299513-8 2007 Our results suggest that high COMT enzyme activity associated with the Val allele predisposes to high sensation seeking scores in female subjects and add to increasing evidence for a gender specific role of COMT in normal and dysfunctional behavior. Valine 71-74 catechol-O-methyltransferase Homo sapiens 207-211 17636131-5 2007 Specifically, the GRM3 genotype putatively associated with suboptimal glutamatergic signaling was significantly associated with inefficient prefrontal engagement and altered prefrontal-parietal coupling on the background of COMT Val-homozygous genotype. Valine 229-232 catechol-O-methyltransferase Homo sapiens 224-228 17548151-3 2007 Functional variation in the human COMT gene occurs at a single nucleotide polymorphism (SNP)--472G>A--that results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met). Valine 123-129 catechol-O-methyltransferase Homo sapiens 34-38 17548151-3 2007 Functional variation in the human COMT gene occurs at a single nucleotide polymorphism (SNP)--472G>A--that results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met). Valine 131-134 catechol-O-methyltransferase Homo sapiens 34-38 17217925-4 2007 METHODS: We genotyped the COMT functional Val(158/108)Met allele in 73 Caucasian adults with 22q11DS (36 men, 37 women; aged 33.8, SD 10.1 years; 37 Met, 36 Val hemizygosity) blind to clinical data and assessed effects on symptoms and frontal functioning. Valine 42-45 catechol-O-methyltransferase Homo sapiens 26-30 17475791-6 2007 We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising both Tower of London (planning) and simple subtracting ("control") problems. Valine 68-74 catechol-O-methyltransferase Homo sapiens 126-130 17475791-6 2007 We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising both Tower of London (planning) and simple subtracting ("control") problems. Valine 68-71 catechol-O-methyltransferase Homo sapiens 126-130 16837108-1 2007 BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. Valine 204-210 catechol-O-methyltransferase Homo sapiens 30-58 16837108-1 2007 BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. Valine 204-210 catechol-O-methyltransferase Homo sapiens 60-64 16837108-4 2007 Four single-nucleotide polymorphisms (SNPs) within COMT gene were evaluated, i.e. rs737865, rs737864, intron 1 C2754delC, and the well-known valine/methionine variant (rs4680). Valine 141-147 catechol-O-methyltransferase Homo sapiens 51-55 17548664-3 2007 The genotype x treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Valine 262-265 catechol-O-methyltransferase Homo sapiens 191-195 17548664-3 2007 The genotype x treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Valine 268-271 catechol-O-methyltransferase Homo sapiens 191-195 17548664-3 2007 The genotype x treatment interaction effect at 12-week follow-up indicated a greater benefit of active nicotine replacement treatment compared with placebo on likelihood of abstinence in the COMT Met/Met genotype group (33% versus 12%), in comparison to the Met/Val + Val/Val group (22% versus 16%). Valine 268-271 catechol-O-methyltransferase Homo sapiens 191-195 17475791-3 2007 Our previous work suggests that a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some of this executive heterogeneity. Valine 66-69 catechol-O-methyltransferase Homo sapiens 90-118 17475791-3 2007 Our previous work suggests that a common functional polymorphism (val(158)met) within the catechol O-methyltransferase (COMT) gene underlies some of this executive heterogeneity. Valine 66-69 catechol-O-methyltransferase Homo sapiens 120-124 17412710-5 2007 The ability to test the hypothesis that COMT might be a susceptibility gene for schizophrenia has been simplified in principle by the existence of a valine-to-methionine (Val/Met) polymorphism which results respectively in high and low activity forms of the enzyme. Valine 171-174 catechol-O-methyltransferase Homo sapiens 40-44 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Valine 63-69 catechol-O-methyltransferase Homo sapiens 57-61 17014828-2 2007 Of two identified alleles (Met and Val), the Met allele results in COMT activity that is up to 4 times less pronounced than that conferred by the Val allele, resulting in greater PFC dopamine concentrations. Valine 35-38 catechol-O-methyltransferase Homo sapiens 67-71 17014828-2 2007 Of two identified alleles (Met and Val), the Met allele results in COMT activity that is up to 4 times less pronounced than that conferred by the Val allele, resulting in greater PFC dopamine concentrations. Valine 146-149 catechol-O-methyltransferase Homo sapiens 67-71 16897602-3 2007 A single-nucleotide polymorphism of COMT gene at position 108/158 results in an amino acid substitution from valine (val) to methionine (met), which modifies its enzymatic activity and may change the brain morphology and expressional behaviors. Valine 109-115 catechol-O-methyltransferase Homo sapiens 36-40 16897602-3 2007 A single-nucleotide polymorphism of COMT gene at position 108/158 results in an amino acid substitution from valine (val) to methionine (met), which modifies its enzymatic activity and may change the brain morphology and expressional behaviors. Valine 109-112 catechol-O-methyltransferase Homo sapiens 36-40 17198907-5 2007 METHODS: In the 1995-97 Nord-Trondelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and BP was evaluated in a group of 2966 nondiabetic individuals. Valine 84-87 catechol-O-methyltransferase Homo sapiens 112-116 17442187-5 2007 RESULTS: The most frequent genotype was COMT(Val/Val) (47.2%, 52/110) in control group and COMT(Val/Met) (58.3%, 77/132) in endometrial cancer group. Valine 45-48 catechol-O-methyltransferase Homo sapiens 40-44 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Valine 63-69 catechol-O-methyltransferase Homo sapiens 223-227 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Valine 70-76 catechol-O-methyltransferase Homo sapiens 57-61 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Valine 70-76 catechol-O-methyltransferase Homo sapiens 223-227 16823382-2 2007 A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. Valine 39-42 catechol-O-methyltransferase Homo sapiens 20-24 16823382-2 2007 A common SNP in the COMT gene causes a Val to Met transition at AA158/AA108 (Val158Met), resulting in reduced COMT activity in Met allele carriers. Valine 39-42 catechol-O-methyltransferase Homo sapiens 110-114 16952445-3 2006 We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex. Valine 45-48 catechol-O-methyltransferase Homo sapiens 63-67 16984965-6 2006 Furthermore, there was a tendency for the enrichment of the Val allele of the COMT Val158Met polymorphism with MB-COMT hypomethylation in the patients. Valine 60-63 catechol-O-methyltransferase Homo sapiens 78-82 16984965-6 2006 Furthermore, there was a tendency for the enrichment of the Val allele of the COMT Val158Met polymorphism with MB-COMT hypomethylation in the patients. Valine 60-63 catechol-O-methyltransferase Homo sapiens 114-118 16525418-5 2006 In the nuclear families, significant transmission disequilibrium for the valine allele was observed between the alleles of the Val158Met COMT polymorphism and panic disorder (p<0.01). Valine 73-79 catechol-O-methyltransferase Homo sapiens 137-141 17008817-4 2006 Those with valine (Val158) alleles have increased greater COMT activity and lower prefrontal extracellular dopamine compared with those with the methionine (Met158) substitution. Valine 11-17 catechol-O-methyltransferase Homo sapiens 58-62 16525418-10 2006 These results support the hypothesis that the valine allele of the Val158Met COMT polymorphism or a nearby locus is involved in the etiopathogenesis of panic disorder. Valine 46-52 catechol-O-methyltransferase Homo sapiens 77-81 16884927-2 2006 Literature suggests that the Val/Met single nucleotide polymorphism (SNP) in the COMT gene predicts executive cognition in humans with Val carriers showing poorer performance due to less available synaptic DA. Valine 29-32 catechol-O-methyltransferase Homo sapiens 81-85 16815691-1 2006 BACKGROUND: Previous work suggests that reaction time variability (RTV) in attentional tasks, as a measure of cognitive stability, is associated with degree of Val loading in COMT Val(158)Met genotype, and that this association may be relevant for the aetiology of schizophrenia. Valine 160-163 catechol-O-methyltransferase Homo sapiens 175-179 16969277-0 2006 The high-activity Val allele of the catechol-O-methyltransferase gene predicts greater cognitive deterioration in patients with psychosis. Valine 18-21 catechol-O-methyltransferase Homo sapiens 36-64 16829779-6 2006 BASIC METHODS: We examined the functional polymorphism of val 158 met (catechol-O-methyl transferase) in 143 patients with methamphetamine psychosis and 200 healthy controls in Japan. Valine 58-61 catechol-O-methyltransferase Homo sapiens 71-100 16815691-8 2006 Differential associations with Val and Met alleles across studies suggest indirect effects through gene-gene interactions or the influence of a functional polymorphism near COMT Val(158)Met. Valine 31-34 catechol-O-methyltransferase Homo sapiens 173-177 16362639-4 2006 Genetic analysis revealed an association between the VAL allele of COMT and the inattention scale (F(1, 201) = 7.20, p = 0.008), the hyperactivity/impulsivity scale (F(1, 201) = 4.30, p = 0.039), and the total ASRS scale (F(2, 201) = 7.64, p = 0.006) with highest scores in carriers of the MET/MET genotype. Valine 53-56 catechol-O-methyltransferase Homo sapiens 67-71 16527884-3 2006 For the COMT gene, we selected the G/A nonsynonymous single-nucleotide polymorphism (SNP) that leads to valine-to-methionine (Val/Met) substitution. Valine 126-129 catechol-O-methyltransferase Homo sapiens 8-12