PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Valine	41-44	glutathione S-transferase pi 1	Homo sapiens	29-34	
30617052-8	2019	For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA =0.027), Ile/Val versus Ile/Ile (OR = 1.70; PA =0.011) and Ile/Val+Val/Val versus Ile/Ile (OR = 1.65; PA =0.010).	Valine	146-149	glutathione S-transferase pi 1	Homo sapiens	29-34	
28198496-8	2017	Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93).	Valine	14-17	glutathione S-transferase pi 1	Homo sapiens	28-33	
26044055-8	2015	Furthermore, subgroup analysis by histological types showed that GSTP1 Ile105Val polymorphism was associated with risks of malignant melanoma under the dominant model (Val/Val + Val/Ile vs. Ile/Ile: OR 1.230, 95 % CI 1.017-1.488, P = 0.033).	Valine	77-80	glutathione S-transferase pi 1	Homo sapiens	65-70	
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	86-89	glutathione S-transferase pi 1	Homo sapiens	43-48	
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	90-93	glutathione S-transferase pi 1	Homo sapiens	43-48	
25735248-11	2016	Such major effects were similarly seen for GSTP1 A114V (OR 1.14, 95% CI 1.01-1.29 for Val/Val + Ala/Val vs. Ala/Ala).	Valine	90-93	glutathione S-transferase pi 1	Homo sapiens	43-48	
23053942-11	2012	However, GSTP1 ile105 val gene polymorphism was not associated with HCC risk in Asian population.	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	9-14	
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	72-78	glutathione S-transferase pi 1	Homo sapiens	50-55	
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	102-108	glutathione S-transferase pi 1	Homo sapiens	91-96	
26284209-4	2015	RESULTS: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively).	Valine	102-108	glutathione S-transferase pi 1	Homo sapiens	91-96	
24254297-5	2014	Logistic regression analyses showed significant risk for CRC associated with GSTP1 homozygotes for Val-105 (OR 4.82; 95 % CI 1.97-11.80) or for individuals who possessed at least one Val-105 allele (OR 2.54; 95 % CI 1.751-3.703).	Valine	99-102	glutathione S-transferase pi 1	Homo sapiens	77-82	
24254297-5	2014	Logistic regression analyses showed significant risk for CRC associated with GSTP1 homozygotes for Val-105 (OR 4.82; 95 % CI 1.97-11.80) or for individuals who possessed at least one Val-105 allele (OR 2.54; 95 % CI 1.751-3.703).	Valine	183-186	glutathione S-transferase pi 1	Homo sapiens	77-82	
21559761-8	2011	Our results suggest that GSTM1 and GSTT1 null genotype alone, both combined or combined with GSTP1 valine alleles, are associated with higher susceptibility to breast cancer development.	Valine	99-105	glutathione S-transferase pi 1	Homo sapiens	93-98	
21711092-2	2012	The substitution of isoleucine to valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity and hence less capability of effective detoxification.	Valine	34-40	glutathione S-transferase pi 1	Homo sapiens	72-77	
23056073-8	2012	RESULTS: The frequency of the Val allele in exon 5 of the GSTP1 gene in patients with T2DM was higher than that observed in healthy controls (15.2% vs. 9.6%); the difference was considered statistically significant when compared to Ile allele carriers (p = 0.03).	Valine	30-33	glutathione S-transferase pi 1	Homo sapiens	58-63	
22052985-4	2012	Specifically, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A>G (rs1695) determines the amino acid substitution Ile105Val, where the Val-containing enzyme has reduced activity.	Valine	154-157	glutathione S-transferase pi 1	Homo sapiens	82-87	
20480816-3	2010	Occurrence of genotypes Ile/ Val of GSTP1 gene, Pro/Leu in GPX1 gene in the main group were lower vs. that in the reference one.	Valine	29-32	glutathione S-transferase pi 1	Homo sapiens	36-41	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	62-65	glutathione S-transferase pi 1	Homo sapiens	79-84	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84	
21729529-3	2011	The results indicated that the frequently of G allele and Ile/Val + Val/Val of GSTP1 gene (26.7%and 44% respectively) in AL group were higher than those in control group (10% and 16% respectively); the AL risk for persons with Ile/Val + Val/Val was 3.260-fold (95%CI = 1.527 - 5.236) of persons with Ile/Ile.	Valine	68-71	glutathione S-transferase pi 1	Homo sapiens	79-84	
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	6-9	glutathione S-transferase pi 1	Homo sapiens	0-5	
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	23-26	glutathione S-transferase pi 1	Homo sapiens	0-5	
21234761-5	2011	GSTP1 Val carrier (Ile Val+Val/Val) also held a significantly lower susceptibility to CIHM of the p16 promoter (OR = 0.26, 95%CI = 0.08-0.86, p = 0.028).	Valine	23-26	glutathione S-transferase pi 1	Homo sapiens	0-5	
21234761-8	2011	In addition, the GSTP1 Ile/Val carrier (Ile/Val+Val/Val) was also significantly associated with lower mean number of CIHM (1.43 +- 1.03 vs. 0.84 +- 1.07, p = 0.03).	Valine	27-30	glutathione S-transferase pi 1	Homo sapiens	17-22	
21449681-14	2011	Patients with one or two Val alleles of GSTP1 tended to a lower risk of progression compared with Ile/Ile homozygotes, p = 0.067.	Valine	25-28	glutathione S-transferase pi 1	Homo sapiens	40-45	
21128213-4	2010	Patients who had the Val allele of the GSTP1 Ile105Val polymorphism had an increased risk of tumor development (odds ratio = 8.60; 95% confidence interval = 4.74-17.87; P < 0.001).	Valine	21-24	glutathione S-transferase pi 1	Homo sapiens	39-44	
21079113-10	2010	The variant Val allele at the GSTP1 105 codon was associated with a significantly increased risk of surgical complications (P = .046; adjusted relative risk, 1.7; 95% confidence interval, 1.1-2.6).	Valine	12-15	glutathione S-transferase pi 1	Homo sapiens	30-35	
20032267-7	2010	Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme.	Valine	29-32	glutathione S-transferase pi 1	Homo sapiens	17-22	
19580344-6	2009	The statistically significant correlation was found also for the combined genotypes of GSTM1 null and GSTP1 valine homozygosity (OR = 2.7, 95% CI: 1.1-6.1, chi2 = 4.5 and P = 0.03).	Valine	108-114	glutathione S-transferase pi 1	Homo sapiens	102-107	
19240225-4	2009	A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele.	Valine	154-160	glutathione S-transferase pi 1	Homo sapiens	22-27	
18540691-13	2008	Patients carrying the Val/Val genotype in the GSTP1 gene had a lower risk of haematological toxicity (odds ratio = 0.322, 95% CI 0.101, 0.957) than patients with the Ile/Ile genotype.	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	46-51	
18797455-1	2008	A Valine residue at position 105 of the GSTP1 protein results in decreased enzyme activity.	Valine	2-8	glutathione S-transferase pi 1	Homo sapiens	40-45	
18521819-7	2008	The only significant association between increased risk of breast cancer development and GSTs polymorphisms was found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 were combined (p < 0.048, OR = 3.75, 95% CI = 1.01-13.90).	Valine	166-172	glutathione S-transferase pi 1	Homo sapiens	176-181	
17912498-12	2008	Chewers with both of SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (4.6 ng/mg creatinine), and non-chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile (4.7 ng/mg creatinine) had a moderately increased 8-OHdG level.	Valine	47-50	glutathione S-transferase pi 1	Homo sapiens	41-46	
18425393-6	2008	A notable trend was also found in Caucasian women with a history of smoking and at least one valine allele at GSTP1 114 (OR=2.12; 95% CI=1.02-4.41).	Valine	93-99	glutathione S-transferase pi 1	Homo sapiens	110-115	
19258736-5	2009	The valine GSTP1*B (rs1695) allele was present in 35.1% subjects, while the heterozygous form (isoleucine/valine) was the most prevalent genotype (46.6%).	Valine	4-10	glutathione S-transferase pi 1	Homo sapiens	11-16	
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	125-131	glutathione S-transferase pi 1	Homo sapiens	4-9	
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	125-131	glutathione S-transferase pi 1	Homo sapiens	186-191	
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	133-136	glutathione S-transferase pi 1	Homo sapiens	4-9	
18280004-3	2008	The GSTP1*B allele has an A to G transition at nucleotide 313 (codon 105) in exon 5, causing a change of isoleucine (Ile) to valine (Val), which affects the electrophile binding site of GSTP1 and results in an enzyme with reduced activity.	Valine	133-136	glutathione S-transferase pi 1	Homo sapiens	186-191	
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	48-51	glutathione S-transferase pi 1	Homo sapiens	42-47	
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	42-47	
17912498-11	2008	Non-chewers with both SULT1A1 Arg-Arg and GSTP1 Val-Val/Ile-Val (reference group) had the lowest mean level (3.6 ng/mg creatinine), whereas chewers with either SULT1A1 Arg-His or GSTP1 Ile-Ile had the highest 8-OHdG mean level (6.2 ng/mg creatinine; vs. reference group, P = 0.04).	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	42-47	
18540691-13	2008	Patients carrying the Val/Val genotype in the GSTP1 gene had a lower risk of haematological toxicity (odds ratio = 0.322, 95% CI 0.101, 0.957) than patients with the Ile/Ile genotype.	Valine	26-29	glutathione S-transferase pi 1	Homo sapiens	46-51	
16977512-8	2006	Thus we suggest that the Val allele of GSTP1 may have a protective effect for development of COPD.	Valine	25-28	glutathione S-transferase pi 1	Homo sapiens	39-44	
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	58-61	glutathione S-transferase pi 1	Homo sapiens	9-14	
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	9-14	
18085999-6	2007	RESULTS: GSTP1 genotype distribution was Ile/Ile 58%, Ile/Val 35% and Val/Val 7%.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	9-14	
16317430-7	2006	Patients possessing the glutathione S-transferase P1-105 Valine/Valine (GSTP1-105VV) genotype showed a response rate of 67% compared to 21% in patients harbouring at least one GSTP1-105 Isoleucine (GSTP1-105I) allele (P=0.038).	Valine	57-63	glutathione S-transferase pi 1	Homo sapiens	72-77	
16839232-7	2006	The GSTP1 allelic frequency was 0.78 for the Ile allele and 0.22 for the Val allele and the genotype frequency was 58.4% for Ile/Ile, 38.4% for Ile/Val, and 3.1% for Val/Val.	Valine	73-76	glutathione S-transferase pi 1	Homo sapiens	4-9	
16162701-9	2005	After controlling for age, sex, and atopic eczema, compared with participants carrying any Val-105 allele, children who were homozygotic for GSTP1 Ile-105 had a significantly increased risk of physician-diagnosed asthma (adjusted odds ratio [adjOR], 1.94; 95% confidence interval [CI], 1.08 to 3.59).	Valine	91-94	glutathione S-transferase pi 1	Homo sapiens	141-146	
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Valine	23-29	glutathione S-transferase pi 1	Homo sapiens	81-86	
16039055-10	2005	An isoleucine (Ile) to valine (Val) substitution at codon 105 (Ile105Val) in the GSTP1 gene was genotyped.	Valine	31-34	glutathione S-transferase pi 1	Homo sapiens	81-86	
14735473-4	2004	In contrast, frequencies of ile/ile genotype at codon 105 and variant val-ala haplotype of GSTP1 was significantly higher (OR = 1.5; 95% CI = 1.0-2.0) and lower (OR = 1.4; 95% CI = 1.0-1.9) in oral cancer patients compare to controls, respectively.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	91-96	
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	41-44	glutathione S-transferase pi 1	Homo sapiens	30-35	
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35	
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35	
16235992-9	2005	The genotypic distribution of GSTP1 (Ile/Val) were Ile/Ile - 44%, Ile/Val -47% and Val/Val- 9 % whereas, the allelic frequencies were 0.67 for Ile and 0.33 for Val allele.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	30-35	
16000570-9	2005	The more the patients carried GSTP1 variant Val alleles, the poorer the survival rate (adjusted hazard ratio, 1.36; 95% confidence interval, 1.01-1.84; Ptrend = 0.045).	Valine	44-47	glutathione S-transferase pi 1	Homo sapiens	30-35	
15900216-5	2005	The GSTP1 gene displays a polymorphism at codon 105 resulting in an Ile to Val substitution, which alters the enzymatic activity of the protein, and this has been suggested as a putative high-risk genotype in various cancers.	Valine	75-78	glutathione S-transferase pi 1	Homo sapiens	4-9	
15254763-1	2004	GSTP1, which encodes GSTPi, has a polymorphic site at codon 105 (exon 5), where an adenosine-to-guanine (A-G) transition causes an isoleucine-to-valine substitution (I105V).	Valine	145-151	glutathione S-transferase pi 1	Homo sapiens	0-5	
15163523-3	2004	GSTP1 exon 5 gene presents a single-nucleotide polymorphism (a to g) that results into an amino-acid substitution (Ile to Val).	Valine	122-125	glutathione S-transferase pi 1	Homo sapiens	0-5	
15932063-12	2005	The risk of colorectal cancer increased as putative high-risk genotypes increased for the combined genotypes of GSTM1 null, GSTT1 null, and either GSTP1 valine heterozygosity or GSTP1 valine homozygosity (OR = 2.69, 95% CI: 1.02-7.11).	Valine	153-159	glutathione S-transferase pi 1	Homo sapiens	147-152	
15932063-12	2005	The risk of colorectal cancer increased as putative high-risk genotypes increased for the combined genotypes of GSTM1 null, GSTT1 null, and either GSTP1 valine heterozygosity or GSTP1 valine homozygosity (OR = 2.69, 95% CI: 1.02-7.11).	Valine	184-190	glutathione S-transferase pi 1	Homo sapiens	178-183	
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Valine	211-214	glutathione S-transferase pi 1	Homo sapiens	51-56	
15479622-5	2004	A significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); compared with never-drinking women with Ile/Ile genotype, ever-drinking women with the GSTP1 Val allele had almost a three-fold risk of breast cancer (OR = 2.9, 95 % CI = 1.05-7.85), whereas never-drinking women with Val allele had half this risk (OR = 0.5, 95 % CI = 0.27-0.93).	Valine	211-214	glutathione S-transferase pi 1	Homo sapiens	205-210	
11597790-7	2001	The polymorphic site within the exon 5 of GSTP1 results in a Ile-->Val substitution, and the isoleucine GSTpi isoform has been found in vitro to be less active than the valine isoform towards the conjugation of BPDE.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	42-47	
11597790-7	2001	The polymorphic site within the exon 5 of GSTP1 results in a Ile-->Val substitution, and the isoleucine GSTpi isoform has been found in vitro to be less active than the valine isoform towards the conjugation of BPDE.	Valine	172-178	glutathione S-transferase pi 1	Homo sapiens	42-47	
11434510-6	2001	The GSTP1 gene has a polymorphism at codon 105 resulting in an Ile to Val substitution which consequently alters the enzymatic activity of the protein and this has been suggested as a putative high-risk genotype in various cancers.	Valine	70-73	glutathione S-transferase pi 1	Homo sapiens	4-9	
11553769-9	2001	These data suggest that inheritance of at least one Val allele at GSTP1 codon 105 confers a significantly increased risk of developing t-AML after cytotoxic chemotherapy, but not after radiotherapy.	Valine	52-55	glutathione S-transferase pi 1	Homo sapiens	66-71	
11059750-1	2000	A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents.	Valine	95-98	glutathione S-transferase pi 1	Homo sapiens	2-36	
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Valine	160-166	glutathione S-transferase pi 1	Homo sapiens	50-58	
11113459-2	2000	The Pi class human glutathione (GSH) transferase (hGSTP1-1), which is polymorphic in humans with respect to amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), plays an important role in the detoxification of PAH-diol epoxides.	Valine	191-197	glutathione S-transferase pi 1	Homo sapiens	50-58	
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Valine	133-139	glutathione S-transferase pi 1	Homo sapiens	19-25	
11071881-3	2000	Interestingly, the hGSTP1 locus is polymorphic in human populations and involves amino acid residues in positions 104 (isoleucine or valine) and/or 113 (alanine or valine).	Valine	164-170	glutathione S-transferase pi 1	Homo sapiens	19-25	
11307147-5	2001	Both polymorphic GSTP1 alleles have an A-to-G transition in exon 5, causing an isoleucine-to-valine change.	Valine	93-99	glutathione S-transferase pi 1	Homo sapiens	17-22	
10698483-5	2000	GSTP1 catalyzes the detoxification of PAH; the val allele has greater catalytic efficiency toward PAH diol epoxides.	Valine	47-50	glutathione S-transferase pi 1	Homo sapiens	0-5	
10880766-1	2000	The human glutathione S-transferase (GST) P1 alleles coding for Val(105) (hGSTP1*B and/or P1*C) are over- represented in lung cancer patients.	Valine	64-67	glutathione S-transferase pi 1	Homo sapiens	10-44	
10880766-1	2000	The human glutathione S-transferase (GST) P1 alleles coding for Val(105) (hGSTP1*B and/or P1*C) are over- represented in lung cancer patients.	Valine	64-67	glutathione S-transferase pi 1	Homo sapiens	74-80	
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Valine	199-205	glutathione S-transferase pi 1	Homo sapiens	96-104	
10799737-1	2000	The catalytic efficiencies of the allelic variants of human glutathione (GSH) S-transferase Pi (hGSTP1-1), which differ in their primary structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (alanine or valine), in the GSH conjugation (detoxification) of acrolein and crotonaldehyde have been determined.	Valine	230-236	glutathione S-transferase pi 1	Homo sapiens	96-104	
9576856-4	1998	Two human class Pi (P) enzymes (GST P1-1 with Ile or Val at position 105) displayed no activity towards the phospholipid hydroperoxide.	Valine	53-56	glutathione S-transferase pi 1	Homo sapiens	32-38	
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	127-133	glutathione S-transferase pi 1	Homo sapiens	30-37	
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	127-133	glutathione S-transferase pi 1	Homo sapiens	39-47	
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	147-153	glutathione S-transferase pi 1	Homo sapiens	30-37	
10344744-2	1999	The allelic variants of human GSTP1-1 (hGSTP1-1) differ in their structures by the amino acids in positions 104 (isoleucine or valine) and/or 113 (valine or alanine).	Valine	147-153	glutathione S-transferase pi 1	Homo sapiens	39-47	
9525277-1	1998	Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates.	Valine	187-193	glutathione S-transferase pi 1	Homo sapiens	195-202	
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	99-105	glutathione S-transferase pi 1	Homo sapiens	4-9	
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	235-241	glutathione S-transferase pi 1	Homo sapiens	4-9	
9539246-7	1998	For GSTP1, the data were suggestive of a trend of increasing risk with higher numbers of codon 105 valine alleles (compared with isoleucine alleles); a 1.97-fold increased risk of breast cancer (95% CI = 0.77-5.02) was associated with valine/valine homozygosity.	Valine	235-241	glutathione S-transferase pi 1	Homo sapiens	4-9	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	52-58	
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Valine	58-64	glutathione S-transferase pi 1	Homo sapiens	30-38	
9299520-2	1997	The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 113 were produced by site-directed mutagenesis of the cDNA followed by bacterial expression and purification of the proteins.	Valine	101-107	glutathione S-transferase pi 1	Homo sapiens	30-38	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	69-72	glutathione S-transferase pi 1	Homo sapiens	77-83	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	52-58	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83	
9092542-4	1997	The transitions changed codon 104 from ATC (Ile) in hGSTP1*A to GTC (Val) in hGSTP1*B and hGSTP1*C and changed codon 113 from GCG (Ala) to GTG (Val) in hGSTP1*C. Both amino changes are in the electrophile-binding active site of the GST Pi peptide.	Valine	144-147	glutathione S-transferase pi 1	Homo sapiens	77-83	
34052967-3	2021	The aim of this study is to investigate whether individual or combined modifying effects of LOX G/A, GSTM1 active/null, GSTT1 active/null and GSTP1 Ile/Val polymorphisms are related to the risk of lung cancer in relation to smoking in the Egyptian population.	Valine	152-155	glutathione S-transferase pi 1	Homo sapiens	142-147	
31905195-9	2020	The distribution of Val/Val genotype of the GSTP1 rs1695 gene polymorphism had a higher incidence in healthy workers compared with patients with toxic liver damage (p=0.036).	Valine	20-23	glutathione S-transferase pi 1	Homo sapiens	44-49	
31905195-9	2020	The distribution of Val/Val genotype of the GSTP1 rs1695 gene polymorphism had a higher incidence in healthy workers compared with patients with toxic liver damage (p=0.036).	Valine	24-27	glutathione S-transferase pi 1	Homo sapiens	44-49	
31637859-10	2019	Carriers of the GSTP1 Val variant allele had a greater than 2-fold increase in SSc risk (OR = 2.41; P = .0006).	Valine	22-25	glutathione S-transferase pi 1	Homo sapiens	16-21	
33960160-5	2021	We obtained genomic DNA from blood leukocytes and studied the gene polymorphisms of glutathione-S-transferase GSTP1 (Ile/Val) (A313G; rs1695) in real time.	Valine	121-124	glutathione S-transferase pi 1	Homo sapiens	110-115	
33960160-8	2021	For GSTP1 (Ile/Val) polymorphism (A313G, rs1695), significant differences in the distribution of genotype frequencies in the subgroup of men with teratospermia (2=7.00; p=0.03) were revealed.	Valine	15-18	glutathione S-transferase pi 1	Homo sapiens	4-9