PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10217527-6	1999	Kinin B2 antagonists Hoe 140 (10 nM) and [D-Arg0, Hyp3, Thi5,8, D-Phe7]-BK (1 microM) had high affinity in antagonizing BK-induced Ca2+ response with pKB values of 8.90 and 6.99, respectively.	thi5	56-60	kininogen 1	Canis lupus familiaris	120-122	
10217527-6	1999	Kinin B2 antagonists Hoe 140 (10 nM) and [D-Arg0, Hyp3, Thi5,8, D-Phe7]-BK (1 microM) had high affinity in antagonizing BK-induced Ca2+ response with pKB values of 8.90 and 6.99, respectively.	thi5	56-60	kininogen 1	Canis lupus familiaris	72-74	
1320077-8	1992	administration of either bradykinin or prostacyclin induced a significant reduction in MAP in high-dose but not low-dose dexamethasone-treated dogs, administration of a competitive bradykinin antagonist, D-Arg-[Hyp3, Thi5,8, D-Phe7]-bradykinin induced a significant elevation in MAP in low-dose but not high-dose dexamethasone-treated dogs.	thi5	217-221	kininogen 1	Canis lupus familiaris	25-35	
9444622-12	1997	Pretreatment with B2-subtype receptor antagonist, D-Arg, [Hyp3, Thi5,8, D-Phe7] BK inhibited significantly BK-induced increase in SPBF, PBF and PVO2 by 86 +/- 8%, 73 +/- 7% and 85 +/- 6%, respectively.	thi5	64-68	kininogen 1	Canis lupus familiaris	80-82	
9444622-12	1997	Pretreatment with B2-subtype receptor antagonist, D-Arg, [Hyp3, Thi5,8, D-Phe7] BK inhibited significantly BK-induced increase in SPBF, PBF and PVO2 by 86 +/- 8%, 73 +/- 7% and 85 +/- 6%, respectively.	thi5	64-68	kininogen 1	Canis lupus familiaris	107-109	
9117112-11	1997	The selective B1 receptor agonist [des-Arg9]-bradykinin, in the concentration-range 10(-6) to 10(-5) M, induced contractions, which were abolished by the B2 receptor antagonist D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin (Hoe 140; 10(-6) M).	thi5	190-194	kininogen 1	Canis lupus familiaris	45-55	
7982265-4	1994	However, the BDK B2 receptor antagonists des-Arg[Hyp3, Thi5,8, D-Phe7]-BDK and Hoe 140 had high affinity in antagonizing BDK with pKB values of 7.5 +/- 0.3 and 8.7 +/- 0.3, respectively.	thi5	55-59	kininogen 1	Canis lupus familiaris	13-16	
7982265-4	1994	However, the BDK B2 receptor antagonists des-Arg[Hyp3, Thi5,8, D-Phe7]-BDK and Hoe 140 had high affinity in antagonizing BDK with pKB values of 7.5 +/- 0.3 and 8.7 +/- 0.3, respectively.	thi5	55-59	kininogen 1	Canis lupus familiaris	71-74	
7982265-4	1994	However, the BDK B2 receptor antagonists des-Arg[Hyp3, Thi5,8, D-Phe7]-BDK and Hoe 140 had high affinity in antagonizing BDK with pKB values of 7.5 +/- 0.3 and 8.7 +/- 0.3, respectively.	thi5	55-59	kininogen 1	Canis lupus familiaris	71-74	
7712031-16	1995	The order of potency for the inhibition of [3H]-bradykinin binding was kallidin = bradykinin = Hoe 140> [D-Arg0, Hyp3, Thi5,8, D-Phel-bradykinin.6.	thi5	122-126	kininogen 1	Canis lupus familiaris	48-58	
8337517-3	1993	This effect was greatly attenuated by the B2-receptor antagonist (D-Arg, Hyp3, Thi5,8, d-Phe7)-BK but not by the B1-receptor antagonist (Des-Arg9, Leu8)-BK.	thi5	79-83	kininogen 1	Canis lupus familiaris	95-97	
1330625-5	1992	However, the blocking effect and the apparent affinity of [d-Arg0,Hyp3,Thi5,8,D-Phe7]bradykinin (pA2 = 9.6 +/- 0.4) were greater than those with des-Arg9-[Leu8]bradykinin (pA.2 = 7.8 +/- 0.3).	thi5	71-75	kininogen 1	Canis lupus familiaris	85-95	
2905666-3	1988	However, the selective B2-receptor antagonist, D-Arg-[Hyp3,Thi5,8,D-Phe7]BK (10-25 micrograms/min) abolished the reflex effects of 0.03 and 0.1 microgram BK and reduced by 50 to 70% the responses to 1 microgram BK.	thi5	59-63	kininogen 1	Canis lupus familiaris	73-75	
1334347-5	1992	The BK-induced suppression was not affected by addition of des-Arg9-[Leu8]-BK, an antagonist for B1-receptor, but did be completely reversed by addition of B2-receptor antagonist (10(-6) M) [D-Arg0,Hyp3,Thi5,8,D-Phe7]-BK.	thi5	203-207	kininogen 1	Canis lupus familiaris	4-6	
2175443-3	1990	The B2 antagonists D-Arg0 [Hyp3,Thi5,8,D-Phe7]BK (B5630) reversibly inhibited both the dips and the rise with IC50 values of 2.01 x 10(-8) and 1.54 x 10(-7) M, respectively.	thi5	32-36	kininogen 1	Canis lupus familiaris	46-48