PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23045722-0 2012 A novel CaV2.2 channel inhibition by piracetam in peripheral and central neurons. Piracetam 37-46 calcium voltage-gated channel subunit alpha1 B Homo sapiens 8-14 23045722-3 2012 In this study, we investigated the effect of piracetam on Ca(V)2.2 channels in peripheral neurons, using patch-clamp recordings from cultured superior cervical ganglion neurons. Piracetam 45-54 calcium voltage-gated channel subunit alpha1 B Homo sapiens 58-66 23045722-4 2012 In addition, we tested if Ca(V)2.2 channel inhibition could be related with the effects of piracetam on central neurons. Piracetam 91-100 calcium voltage-gated channel subunit alpha1 B Homo sapiens 26-34 23045722-5 2012 We found that piracetam inhibited native Ca(V)2.2 channels in superior cervical ganglion neurons in a dose-dependent manner, with an IC(50) of 3.4 mumol/L and a Hill coefficient of 1.1. Piracetam 14-23 calcium voltage-gated channel subunit alpha1 B Homo sapiens 41-49 23045722-7 2012 Piracetam altered the biophysical characteristics of Ca(V)2.2 channel such as facilitation ratio. Piracetam 0-9 calcium voltage-gated channel subunit alpha1 B Homo sapiens 53-61