PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29775538-5 2018 Changing to a pyrazine followed by optimization of substituents on both the oxazine and the pyrazine culminated in 24 with robust Abeta reduction in vivo at low doses as well as reduced CYP2D6 inhibition. Oxazines 76-83 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 186-192