PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11574406-3	2001	The aim of this study was to investigate the domains of the K(ATP) channel involved in nicorandil activity and to determine whether nicorandil interacts with hypoglycemic sulfonylureas that target K(ATP) channels in pancreatic beta-cells.	Nicorandil	87-97	ATPase phospholipid transporting 8A2	Homo sapiens	62-65	
11574406-3	2001	The aim of this study was to investigate the domains of the K(ATP) channel involved in nicorandil activity and to determine whether nicorandil interacts with hypoglycemic sulfonylureas that target K(ATP) channels in pancreatic beta-cells.	Nicorandil	132-142	ATPase phospholipid transporting 8A2	Homo sapiens	199-202	
11574406-6	2001	Nicorandil activated Kir6.2/SUR2A and Kir6.2/SUR2B but not Kir6.2/SUR1 currents, consistent with its specificity for cardiac and smooth muscle K(ATP) channels.	Nicorandil	0-10	ATPase phospholipid transporting 8A2	Homo sapiens	145-148	
11574406-10	2001	Finally, we showed that nicorandil activity was unaffected by gliclazide, which specifically blocks SUR1-type K(ATP) channels, but was severely impaired by glibenclamide and glimepiride, which target both SUR1 and SUR2-type K(ATP) channels.	Nicorandil	24-34	ATPase phospholipid transporting 8A2	Homo sapiens	214-230	
15320472-6	2003	Recent clinical studies have shown that a combination of coronary reperfusion therapy and infusion of nicorandil, a hybrid of K(ATP) channel opener and nitrate, improved left ventricular function in patients with acute myocardial infarction.	Nicorandil	102-112	ATPase phospholipid transporting 8A2	Homo sapiens	128-131	
10674713-9	2000	Nevertheless, K(ATP) and K(NDP) channels are both activated by K+ channel openers, including pinacidil and nicorandil, and inhibited by sulfonylurea derivatives such as glibenclamide.	Nicorandil	107-117	ATPase phospholipid transporting 8A2	Homo sapiens	16-19	
9692785-0	1998	SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.	Nicorandil	114-124	ATPase phospholipid transporting 8A2	Homo sapiens	71-74	
9692785-12	1998	Thus, nicorandil, but not pinacidil, preferentially activates the K(ATP) channels containing SUR2B.	Nicorandil	6-16	ATPase phospholipid transporting 8A2	Homo sapiens	68-71	
9692785-13	1998	Because SUR2A and SUR2B are diverse only in 42 amino acids at their C-terminal ends, it is strongly suggested that this short part of SUR2B may play a critical role in the action of nicorandil on the vascular type classical K(ATP) channel.	Nicorandil	182-192	ATPase phospholipid transporting 8A2	Homo sapiens	200-230