PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34034564-0	2021	Nicorandil inhibits TLR4/MyD88/NF-kappaB/NLRP3 signaling pathway to reduce pyroptosis in rats with myocardial infarction.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	20-24	
34034564-12	2021	The achieved data implicate that myocardial infarction induces pyroptosis via the TLR4/MyD88/NF-kappaB/NLRP3 pathway, which can be inhibited by nicorandil pretreatment.	Nicorandil	144-154	toll-like receptor 4	Rattus norvegicus	82-86	
34034564-13	2021	Therefore, nicorandil exerts cardioprotective effects by activating KATP channels, and at least in part through inhibition of the TLR4/MyD88/NF-kappaB/NLRP3 pathway to reduce myocardial infarction-induced pyroptosis.	Nicorandil	11-21	toll-like receptor 4	Rattus norvegicus	130-134	
31376360-0	2019	Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFkappa-B signaling pathway.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	71-75	
31376360-2	2019	A precise method was elucidated to study the effect of nicorandil on doxorubicin-induced nephrotoxicity in rats depending on the critical inflammation pathway TLR4/MAPK P38/NFkappa-B.	Nicorandil	55-65	toll-like receptor 4	Rattus norvegicus	159-163	
31376360-9	2019	Nicorandil is a promising antidote against doxorubicin-induced nephrotoxicity by neutralizing all toxicity mechanisms caused by doxorubicin through normalizing inflammatory cascade of TLR4/MAPK P38/NFkappa-B.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	184-188	
30611783-0	2019	Nicorandil abates arthritic perturbations induced by complete Freund"s adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	103-107	
30611783-10	2019	CONCLUSION AND IMPLICATIONS: Nicorandil, via interfering with TLR4 signaling, sheds light on a potential clinical role of the drug in pursuit for safe and effective regimens for RA.	Nicorandil	29-39	toll-like receptor 4	Rattus norvegicus	62-66	
29990871-0	2018	Role of TLR4/MyD88/NF-kappaB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.	Nicorandil	130-140	toll-like receptor 4	Rattus norvegicus	8-12	
29990871-6	2018	Nicorandil treatment seven days before CME induction effectively inhibited myocardial inflammation, ameliorated myocardial injury, and improved cardiac function, mainly by inhibiting Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappa B (NF-kappaB) signaling.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	183-203	
29990871-6	2018	Nicorandil treatment seven days before CME induction effectively inhibited myocardial inflammation, ameliorated myocardial injury, and improved cardiac function, mainly by inhibiting Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappa B (NF-kappaB) signaling.	Nicorandil	0-10	toll-like receptor 4	Rattus norvegicus	205-209	
29990871-9	2018	In summary, nicorandil significantly protected cardiomyocytes from CME-induced myocardial injury mainly by inhibiting TLR4/MyD88/NF-kappaB signaling, thereby reducing the onset of CME-induced myocardial inflammation.	Nicorandil	12-22	toll-like receptor 4	Rattus norvegicus	118-122