PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15258252-12 2004 Nicorandil activated SUR2x(D834N, E1471Q)/Kir6.2 channels more strongly in the presence of Na-ATP than K-ATP alone, whereas the reverse was true for wild-type SUR2x/Kir6.2 channels. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 42-48 23739550-9 2013 The antianginal drug nicorandil activated Kir6.2/SUR2B-V734I channels, thus substituting for the loss of MgNDP stimulation, suggesting that this drug could be of therapeutic use in the treatment of AMI associated with V734I. Nicorandil 21-31 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 42-48 15978900-7 2005 Nonetheless, nicorandil ~100 times more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels. Nicorandil 13-23 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 65-71 15258252-12 2004 Nicorandil activated SUR2x(D834N, E1471Q)/Kir6.2 channels more strongly in the presence of Na-ATP than K-ATP alone, whereas the reverse was true for wild-type SUR2x/Kir6.2 channels. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 165-171 11574406-6 2001 Nicorandil activated Kir6.2/SUR2A and Kir6.2/SUR2B but not Kir6.2/SUR1 currents, consistent with its specificity for cardiac and smooth muscle K(ATP) channels. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 21-27 15102948-1 2004 Nicorandil activates ATP-sensitive K(+) channels composed of Kir6.2 and either sulfonylurea receptor (SUR) 2A or 2B. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 61-67 15102948-2 2004 Although SUR2A and SUR2B differ only in their C-terminal 42 amino acids (C42) and possess identical drug receptors and nucleotide-binding domains (NBDs), nicorandil more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels. Nicorandil 154-164 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 195-201 15102948-2 2004 Although SUR2A and SUR2B differ only in their C-terminal 42 amino acids (C42) and possess identical drug receptors and nucleotide-binding domains (NBDs), nicorandil more potently activates SUR2B/Kir6.2 than SUR2A/Kir6.2 channels. Nicorandil 154-164 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 213-219 15102948-8 2004 Thus, the SUR2A/Kir6.2 channels" response to nicorandil critically depends on ATP-NBD1 interaction and is facilitated by interactions of ATP or ADP with NBD2. Nicorandil 45-55 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 16-22 15102948-9 2004 In SUR2B/Kir6.2 channels, either the K708A or K1349A mutation partially suppressed the response to nicorandil, and double mutations abolished it. Nicorandil 99-109 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 9-15 15102948-12 2004 Thus, NBD2 hydrolyzes ATP, and NBD1 and NBD2 equally contribute to the response by interacting with ATP and ADP, accounting for the higher nicorandil sensitivity of SUR2B/Kir6.2 than SUR2A/Kir6.2 channels in the presence of ATP alone. Nicorandil 139-149 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 171-177 15102948-12 2004 Thus, NBD2 hydrolyzes ATP, and NBD1 and NBD2 equally contribute to the response by interacting with ATP and ADP, accounting for the higher nicorandil sensitivity of SUR2B/Kir6.2 than SUR2A/Kir6.2 channels in the presence of ATP alone. Nicorandil 139-149 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 189-195 11574406-6 2001 Nicorandil activated Kir6.2/SUR2A and Kir6.2/SUR2B but not Kir6.2/SUR1 currents, consistent with its specificity for cardiac and smooth muscle K(ATP) channels. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 38-44 11574406-6 2001 Nicorandil activated Kir6.2/SUR2A and Kir6.2/SUR2B but not Kir6.2/SUR1 currents, consistent with its specificity for cardiac and smooth muscle K(ATP) channels. Nicorandil 0-10 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 38-44 9692785-10 1998 On the other hand, nicorandil activated the SUR2B/Kir6.2 channel > 100 times more potently than the SUR2A/Kir6.2 (EC50 of approximately 10 microM and > 500 microM, respectively). Nicorandil 19-29 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 50-56 9479011-2 1998 The SUR2A/Kir6.2 channel was activated effectively by pinacidil, marginally by nicorandil but not by diazoxide. Nicorandil 79-89 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 10-16