PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8517869-3	1993	Pretreatment with 1,3-bis(chloroethyl)-1-nitrosourea (BCNU) (0.1 mM) for 30 min, which irreversibly inhibited glutathione reductase (GSSG-Rd) activity, increased the extent of GSSG formation produced by APAP exposure and potentiated its cell killing.	Acetaminophen	203-207	glutathione reductase	Mus musculus	110-131	
33090425-4	2020	RESULTS: APAP caused liver toxicity as indicated by increased serum alanine aminotransferase and liver microscopic pathology, decreased hepatic superoxide dismutase and glutathione reductase activities, without affecting nuclear factor erythroid 2-related factor 2 (Nrf2) expression.	Acetaminophen	9-13	glutathione reductase	Mus musculus	169-190	
28447517-9	2017	Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase were significantly attenuated in the liver of mice by 85.10, 80.81, 80.45, 76.23 and 95.22%, respectively.	Acetaminophen	11-24	glutathione reductase	Mus musculus	116-137	
31739724-6	2020	APAP group showed a significant increase in liver weight, ALT, AST, ALP, MDA, and PCNA expression with a significant decrease in glutathione reductase in comparison to control group.	Acetaminophen	0-4	glutathione reductase	Mus musculus	129-150	
27161652-4	2016	Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6- phosphate dehydrogenase were significantly attenuated in the liver of mice.	Acetaminophen	11-24	glutathione reductase	Mus musculus	116-137	
28612711-6	2017	APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver.	Acetaminophen	0-4	glutathione reductase	Mus musculus	181-202	
28612711-6	2017	APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver.	Acetaminophen	0-4	glutathione reductase	Mus musculus	204-206	
27069324-7	2016	This results demonstrate that APAP induced toxicity in AML-12, increased aldose reductase expression, and over-expression of aldose reductase render this cell more susceptible to APAP induced oxidative stress and cell death, this probably due to inhibition AMPK or bcl-2 activity, or may due to competition between aldose reductase and glutathione reductase for NADPH.	Acetaminophen	30-34	glutathione reductase	Mus musculus	336-357	
27161000-5	2016	APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver.	Acetaminophen	0-4	glutathione reductase	Mus musculus	181-202	
27161000-5	2016	APAP treatment decreased glutathione (GSH) level, increased reactive oxygen species (ROS) and oxidized glutathione (GSSG) production; and lowered activity and protein expression of glutathione reductase (GR) and heme oxygenase (HO)-1 in liver.	Acetaminophen	0-4	glutathione reductase	Mus musculus	204-206	
20933533-4	2011	Acetaminophen significantly increased the levels of aspartate transaminase, alanine transaminase, myeloperoxidase, lipid peroxidation, and glutathione reductase, but it decreased superoxide dismutase, catalase, and glutathione.	Acetaminophen	0-13	glutathione reductase	Mus musculus	139-160	
24392788-8	2014	Habb-e-Asgand alone and in combination of paracetamol significantly (p < 0.05, 0.01, 0.001) decreased LFT levels (20-25%), CYP activity (~45%) and LPO level (~25%), while it induced antioxidant enzyme activity (GR, ~15%; GPx, ~17%; GST, ~20% and CAT, ~60%).	Acetaminophen	42-53	glutathione reductase	Mus musculus	214-216	
25645189-7	2015	Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase was significantly (P<0.05) attenuated in the liver of mice.	Acetaminophen	11-24	glutathione reductase	Mus musculus	116-137