PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25645189-7 2015 Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase was significantly (P<0.05) attenuated in the liver of mice. Acetaminophen 11-24 catalase Mus musculus 82-90 7557544-9 1995 Catalase was slightly inhibited (30%) 15 min after acetaminophen administration. Acetaminophen 51-64 catalase Mus musculus 0-8 19462927-4 2009 For this reason we undertook a study of the effects of these extracts alone and in combination with paracetamol, along with the action of paracetamol alone, on the activity of the antioxidant enzymes GSHPx, CAT, Px, XOD, GSHR, glutathione content, LPx intensity, as well as activities of AST and ALT. Acetaminophen 100-111 catalase Mus musculus 207-210 19462927-7 2009 In combination with paracetamol, extracts of both Magnum and Aroma varieties reduced significantly the LPx intensity, activities of CAT and GSHPx, as well as GSH content in the liver homogenate. Acetaminophen 20-31 catalase Mus musculus 132-135 19230593-4 2008 For this reason we undertook a study of the effects of these extracts alone and in combination with paracetamol, along with the action of paracetamol alone, on the activity of the antioxidant enzymes GSHPx, CAT, Px, XOD, GSHR, glutathione content, LPx intensity, as well as activities of AST and ALT. Acetaminophen 100-111 catalase Mus musculus 207-210 19230593-7 2008 In combination with paracetamol, extracts of both Magnum and Aroma varieties reduced significantly the LPx intensity, activities of CAT and GSHPx, as well as GSH content in the liver homogenate. Acetaminophen 20-31 catalase Mus musculus 132-135 18054472-8 2008 There were general statistically significant losses in the activities of SOD, GPx, CAT, and delta-ALA-D and an increase in TBARS in the liver of paracetamol-treated group compared with the control group. Acetaminophen 145-156 catalase Mus musculus 83-86 24392788-8 2014 Habb-e-Asgand alone and in combination of paracetamol significantly (p < 0.05, 0.01, 0.001) decreased LFT levels (20-25%), CYP activity (~45%) and LPO level (~25%), while it induced antioxidant enzyme activity (GR, ~15%; GPx, ~17%; GST, ~20% and CAT, ~60%). Acetaminophen 42-53 catalase Mus musculus 249-252 20933533-4 2011 Acetaminophen significantly increased the levels of aspartate transaminase, alanine transaminase, myeloperoxidase, lipid peroxidation, and glutathione reductase, but it decreased superoxide dismutase, catalase, and glutathione. Acetaminophen 0-13 catalase Mus musculus 201-209 19799668-5 2009 Acetaminophen treatment significantly depleted hepatic GSH and ascorbic acid levels, increased hepatic level of malonyldialdehyde (MDA), reactive oxygen species (ROS), and oxidized glutathione (GSSG), as well as decreased hepatic activity of glutathione peroxidase (GPX), catalase, and superoxide dismutase (SOD) (P < 0.05). Acetaminophen 0-13 catalase Mus musculus 272-280 19799668-6 2009 However, the pre-intake of carnosine or histidine significantly alleviated acetaminophen-induced oxidative stress by increasing GSH content, decreasing MDA, ROS, and GSSG formations, and retaining activity of GPX, catalase, and SOD in liver (P < 0.05). Acetaminophen 75-88 catalase Mus musculus 214-222 18579359-5 2008 Acetaminophen treatment also caused significant GSH depletion, malondialdehyde (MDA) and reactive oxygen species (ROS) increase, and activity reduction of glutathione peroxidase (GPX) and catalase. Acetaminophen 0-13 catalase Mus musculus 188-196 35578873-10 2022 Furthermore, compared with the APAP group, hepatic antioxidants, including 3-Nitrotyrosine, High mobility group protein B1, superoxide dismutase, catalase, and glutathionewere increased of APAP + anti-TLR4 IgG2 group. Acetaminophen 31-35 catalase Mus musculus 146-154 1707707-20 1990 Intraperitoneal administration of a mixture of superoxide dismutase and catalase reduced detectable superoxide anion by 98% without inhibiting the writhing response to zymosan or the antinociceptive potency of paracetamol. Acetaminophen 210-221 catalase Mus musculus 72-80 27161652-4 2016 Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6- phosphate dehydrogenase were significantly attenuated in the liver of mice. Acetaminophen 11-24 catalase Mus musculus 82-90 35126160-9 2022 APAP treatment increased liver malondialdehyde (MDA) content and reduced catalase (CAT) and glutathione (GSH) level; however, these effects were alleviated by AO-I intervention. Acetaminophen 0-4 catalase Mus musculus 73-81 35126160-9 2022 APAP treatment increased liver malondialdehyde (MDA) content and reduced catalase (CAT) and glutathione (GSH) level; however, these effects were alleviated by AO-I intervention. Acetaminophen 0-4 catalase Mus musculus 83-86 33088439-13 2020 Enhanced SOD and CAT protein expression levels were increased in APAP-induced liver injury. Acetaminophen 65-69 catalase Mus musculus 17-20 30777790-7 2019 We found that acetaminophen significantly increased the levels of serum ALP, ALT, AST and MDA, and also significantly reduced the antioxidant factors, CAT, GPX and SOD. Acetaminophen 14-27 catalase Mus musculus 151-154 28447517-9 2017 Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase were significantly attenuated in the liver of mice by 85.10, 80.81, 80.45, 76.23 and 95.22%, respectively. Acetaminophen 11-24 catalase Mus musculus 82-90 28376392-5 2017 The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the APAP-induced hepatotoxicity mice were significantly reduced (lower to ~65%), while their activities were increased by pretreatment with TA (25 and 50mg/kg) (P<0.05). Acetaminophen 104-108 catalase Mus musculus 46-54 28376392-5 2017 The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the APAP-induced hepatotoxicity mice were significantly reduced (lower to ~65%), while their activities were increased by pretreatment with TA (25 and 50mg/kg) (P<0.05). Acetaminophen 104-108 catalase Mus musculus 56-59 35285202-8 2022 Compared with the APAP group, the combination groups showed reduced APAP-induced ALT level and liver MDA content, potentiated liver CAT activity, and elevated GSH content. Acetaminophen 18-22 catalase Mus musculus 132-135 33951559-10 2021 Moreover, APAP-induced upregulation of antioxidant genes, such as hepatic heme oxygenase-1 (Ho-1), glutathione peroxidase (Gshpx), superoxide dismutase 1 (Sod1) and catalase enzymes (Cat), was aggravated in VDD-fed mice. Acetaminophen 10-14 catalase Mus musculus 165-181 33951559-10 2021 Moreover, APAP-induced upregulation of antioxidant genes, such as hepatic heme oxygenase-1 (Ho-1), glutathione peroxidase (Gshpx), superoxide dismutase 1 (Sod1) and catalase enzymes (Cat), was aggravated in VDD-fed mice. Acetaminophen 10-14 catalase Mus musculus 183-186 32904181-10 2021 In mice, pre-administration with GMSYS alleviated APAP-induced hepatotoxicity by decreasing plasma ALT and AST activities and hepatic malondialdehyde, and by increasing the total glutathione (GSH)/reduced GSH ratio and the activities of several antioxidants such as superoxide dismutase, catalase, GSH peroxidase, GSH reductase, GSH-S-transferase, and heme oxygenase-1. Acetaminophen 50-54 catalase Mus musculus 288-296 31142171-10 2019 In addition, the combination of SFN and APAP at low doses decreased intracellular ROS formation and increased the protein levels of CAT, GPx, Nrf2, NQO1, and HO-1, which were much better than APAP alone and were equivalent to SFN at full dose. Acetaminophen 40-44 catalase Mus musculus 132-135