PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34867421-5	2021	In this study, we therefore evaluated the effects of AM404 and acetaminophen on the arachidonic acid cascade and oxidative stress induced by interleukin (IL)-1beta in human SK-N-SH neuronal cells.	Acetaminophen	63-76	interleukin 1 alpha	Homo sapiens	141-163	
1981242-9	1990	Acetaminophen in high concentrations (1 mg/ml) inhibited IL-1 activity and production.	Acetaminophen	0-13	interleukin 1 alpha	Homo sapiens	57-61	
34867421-6	2021	We observed that AM404 and acetaminophen significantly and concentration-dependent inhibited IL-1beta-induced release of PGE2, independent of cyclooxygenases (COX)-1 and COX-2 enzymatic activity as well as COX-2 mRNA and protein levels in SK-N-SH-cells.	Acetaminophen	27-40	interleukin 1 alpha	Homo sapiens	93-101	
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Acetaminophen	60-73	interleukin 1 alpha	Homo sapiens	17-25	
34867421-7	2021	The reduction of IL-1beta-induced PGE2-release by AM404 and acetaminophen treatment might be mediated by the 8-iso-PGF2alpha pathway since IL-1beta-induced synthesis of this free radical marker is dose-dependently reduced by both compounds, respectively.	Acetaminophen	60-73	interleukin 1 alpha	Homo sapiens	139-147	
32062076-6	2020	Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1.	Acetaminophen	24-28	interleukin 1 alpha	Homo sapiens	109-117	
34294366-4	2021	Moreover, hucMSC-Exo significantly down-regulated the levels of inflammatory cytokines IL-6, IL-1beta, and TNF-alpha in APAP-treated livers.	Acetaminophen	120-124	interleukin 1 alpha	Homo sapiens	93-101	
12011469-2	2002	We find parallel selectivity at a cellular level; acetaminophen inhibits PGHS activity with an IC(50) of 4.3 microM in interleukin (IL)-1 alpha-stimulated human umbilical vein endothelial cells, in contrast with an IC(50) of 1,870 microM for the platelet, with 2 microM arachidonic acid as substrate.	Acetaminophen	50-63	interleukin 1 alpha	Homo sapiens	119-143	
29151582-0	2018	IL-1alpha in acetaminophen toxicity: a sterile danger signal.	Acetaminophen	13-26	interleukin 1 alpha	Homo sapiens	0-9