PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. Acetaminophen 24-28 interleukin 6 Homo sapiens 127-131 34294366-4 2021 Moreover, hucMSC-Exo significantly down-regulated the levels of inflammatory cytokines IL-6, IL-1beta, and TNF-alpha in APAP-treated livers. Acetaminophen 120-124 interleukin 6 Homo sapiens 87-91 14567536-6 2003 Interleukin-6 and tumour necrosis factor-alpha levels increased in both patient groups, but were higher in paracetamol overdose. Acetaminophen 107-118 interleukin 6 Homo sapiens 0-46 26869439-6 2016 LPS-activated HKCCs, but not hepatocyte monocultures, treated with trovafloxacin or acetaminophen, compounds associated with immune-mediated hepatotoxicity, showed LPS-dependent decreases in interleukin-6 production with concomitant increases in Cyp3A activity. Acetaminophen 84-97 interleukin 6 Homo sapiens 191-204 32013615-5 2022 APAP significantly (p < 0.05) increased blood levels of urea, creatinine, malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), which were effectively reduced by RES + QUR. Acetaminophen 0-4 interleukin 6 Homo sapiens 100-113 32013615-5 2022 APAP significantly (p < 0.05) increased blood levels of urea, creatinine, malondialdehyde (MDA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), which were effectively reduced by RES + QUR. Acetaminophen 0-4 interleukin 6 Homo sapiens 115-119 31059760-7 2019 Compared to the treatment with LPS only, LPS/APAP co-exposures induced the production of interleukin (IL)-8, a pro-inflammatory cytokine, but suppressed the secretion of IL-6, a cytokine regulating hepatic regeneration, along with the increase in APAP dosages. Acetaminophen 45-49 interleukin 6 Homo sapiens 170-174 27768523-6 2017 Acetaminophen and ibuprofen were used to block the effect of IL-6 at a central and peripheral level, respectively. Acetaminophen 0-13 interleukin 6 Homo sapiens 61-65 23351502-9 2012 Levels of IL-6 and IL-10 decreased significantly (p = 0.025 and p = 0.047, respectively) in the paracetamol group at 24 hours but this was not of statistical significance in control group. Acetaminophen 96-107 interleukin 6 Homo sapiens 10-14 23743397-0 2013 Short-term acetaminophen consumption enhances the exercise-induced increase in Achilles peritendinous IL-6 in humans. Acetaminophen 11-24 interleukin 6 Homo sapiens 102-106 23434081-6 2013 IL-6 in piglet plasma of the AAP group (mixed feed concentration of 600 mg/kg) was significantly reduced (P<0.05) at 3h after LPS-challenge as compared with the LPS control group. Acetaminophen 29-32 interleukin 6 Homo sapiens 0-4 15878691-7 2005 In macrophages, acetaminophen decreased the secretion of TNF-alpha (at 4 and 24 h, concentration-related) and IL-6 (at 24 h, at 0.1 mM), and did not affect significantly IL-8 production. Acetaminophen 16-29 interleukin 6 Homo sapiens 110-114 15878691-8 2005 These in vitro observations demonstrate that clinically relevant concentrations of acetaminophen decreased: (i) intracellular GSH in human pulmonary macrophages and type II pneumocytes and (ii) the secretion of TNF-alpha and possibly IL-6 by human pulmonary macrophages. Acetaminophen 83-96 interleukin 6 Homo sapiens 234-238