PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19164858-6	2009	By activating caspase-1, the enzyme responsible for generating mature IL-1beta and IL-18 from pro-IL-1beta and pro-IL-18, respectively, the Nalp3 inflammasome plays a crucial role in the second step of proinflammatory cytokine activation following acetaminophen-induced liver injury.	Acetaminophen	248-261	interleukin 18	Mus musculus	83-88	
19164858-6	2009	By activating caspase-1, the enzyme responsible for generating mature IL-1beta and IL-18 from pro-IL-1beta and pro-IL-18, respectively, the Nalp3 inflammasome plays a crucial role in the second step of proinflammatory cytokine activation following acetaminophen-induced liver injury.	Acetaminophen	248-261	interleukin 18	Mus musculus	115-120	
11133864-4	2001	METHODS: IL-18 detection was performed by using 5-bromo-4-chloro-3-indoyl-ss--D-galactopyranoside (X-Gal) staining on frozen sections of eyes from mice (129/CD1, DBA1, and Balb/c), either of normal phenotype (+/+) or of deficiency (+/-, -/-) in the IL-18 gene which had been replaced by introduced genes including LacZ under the control of an IL-18 promotor.	Acetaminophen	99-100	interleukin 18	Mus musculus	9-14	
35310165-9	2022	In vitro experiment indicated that DAG dose-dependently inhibited APAP-induced the levels of pro-inflammatory factors (IL-1beta and IL18), and reactive oxygen species (ROS) and preventing GSH depletion in mouse AML12 hepatocytes.	Acetaminophen	66-70	interleukin 18	Mus musculus	132-136	
24798499-8	2014	Moreover, BA prevented APAP-induced inflammasome signaling as determined by interleukin (IL)-1beta, IL-18, and caspase-1 cleavage in liver tissues.	Acetaminophen	23-27	interleukin 18	Mus musculus	100-105