PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22566695-0 2012 Polymorphism of beta2-microglobulin amyloid fibrils manifested by ultrasonication-enhanced fibril formation in trifluoroethanol. Trifluoroethanol 111-127 beta-2-microglobulin Homo sapiens 16-35 22777780-5 2012 Protein engineering, or the addition of Cu(2+) ions, sodium dodecyl sulphate, trifluoroethanol, heparin, or protein stabilisers, was employed to perturb the conformational dynamics of beta(2)m. Trifluoroethanol 78-94 beta-2-microglobulin Homo sapiens 184-192 22566695-2 2012 Here, we have found that, in combination with an enhancing effect of ultrasonication on nucleation, beta(2)-microglobulin, a protein responsible for dialysis-related amyloidosis, generates distinct fibril conformations in a concentration-dependent manner in the presence of 2,2,2-trifluoroethanol (TFE). Trifluoroethanol 274-296 beta-2-microglobulin Homo sapiens 100-121 22566695-2 2012 Here, we have found that, in combination with an enhancing effect of ultrasonication on nucleation, beta(2)-microglobulin, a protein responsible for dialysis-related amyloidosis, generates distinct fibril conformations in a concentration-dependent manner in the presence of 2,2,2-trifluoroethanol (TFE). Trifluoroethanol 298-301 beta-2-microglobulin Homo sapiens 100-121 21766392-2 2011 This study describes conformational properties of beta2m under two distinct, in vitro amyloidogenic conditions: neutral pH in the presence of 20% 2,2,2-trifluoroethanol (TFE) and acidic pH in the absence of TFE. Trifluoroethanol 146-168 beta-2-microglobulin Homo sapiens 50-56 21766392-2 2011 This study describes conformational properties of beta2m under two distinct, in vitro amyloidogenic conditions: neutral pH in the presence of 20% 2,2,2-trifluoroethanol (TFE) and acidic pH in the absence of TFE. Trifluoroethanol 170-173 beta-2-microglobulin Homo sapiens 50-56 21766392-2 2011 This study describes conformational properties of beta2m under two distinct, in vitro amyloidogenic conditions: neutral pH in the presence of 20% 2,2,2-trifluoroethanol (TFE) and acidic pH in the absence of TFE. Trifluoroethanol 207-210 beta-2-microglobulin Homo sapiens 50-56 20558175-3 2010 This article gives some insights into the structural properties and the conformational states of beta(2)-microglobulin in the presence of TFE, using both the wild-type protein and the mutant Trp60Gly. Trifluoroethanol 138-141 beta-2-microglobulin Homo sapiens 97-118 16084781-4 2005 Very recently, low concentrations of 2,2,2-trifluoroethanol (TFE) and the sub-micellar concentration of sodium dodecyl sulfate, a model for anionic phospholipids, have been reported to cause the extension of Abeta(2)M amyloid fibrils at a neutral pH, inducing partial unfolding of beta(2)-m and stabilization of the fibrils. Trifluoroethanol 37-59 beta-2-microglobulin Homo sapiens 281-290 16084781-4 2005 Very recently, low concentrations of 2,2,2-trifluoroethanol (TFE) and the sub-micellar concentration of sodium dodecyl sulfate, a model for anionic phospholipids, have been reported to cause the extension of Abeta(2)M amyloid fibrils at a neutral pH, inducing partial unfolding of beta(2)-m and stabilization of the fibrils. Trifluoroethanol 61-64 beta-2-microglobulin Homo sapiens 281-290 11418618-4 2001 Upon treatment of wild-type beta(2)-microglobulin with acetonitrile or trifluoroethanol, two conformations were also observed. Trifluoroethanol 71-87 beta-2-microglobulin Homo sapiens 28-49 15628856-3 2005 A 22-residue peptide of beta(2)-microglobulin, Ser20-Lys41 (L-K3 peptide), obtained by digestion with Acromobacter protease I, formed amyloid-like fibrils in 50% (v/v) 2,2,2-trifluoroethanol and 10 mM HCl at 25 degrees C, as confirmed by thioflavin T fluorescence, circular dichroism spectra, and atomic force microscopy images. Trifluoroethanol 174-190 beta-2-microglobulin Homo sapiens 24-45 14694164-0 2004 Glycosaminoglycans enhance the trifluoroethanol-induced extension of beta 2-microglobulin-related amyloid fibrils at a neutral pH. Trifluoroethanol 31-47 beta-2-microglobulin Homo sapiens 69-89 14694164-4 2004 Trifluoroethanol at concentrations of up to 20% (vol/vol) caused fibril extension of heparin-stabilized seeds, inducing a subtle change in the tertiary structure of beta(2)-microglobulin and stabilizing the fibrils at a neutral pH. Trifluoroethanol 0-16 beta-2-microglobulin Homo sapiens 165-186