PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12153580-2 2002 With the aim to distinguish between local and global conformational changes induced by trifluoroethanol in RNase A, spectroscopic and activity measurements in combination with proteolysis by unspecific proteases have been exploited for probing structural transitions of RNase A as a function of trifluoroethanol concentration. Trifluoroethanol 87-103 ribonuclease A family member 1, pancreatic Homo sapiens 107-114 18225649-4 2007 The same peptide bonds are splitted by proteases with the highest rate upon the denaturation in the presense of trifluoroethanol or the renaturation from concentrated urea solutions and after the desorganization of the native structure by the reduction of all four S-S bonds of RNase A. Trifluoroethanol 112-128 ribonuclease A family member 1, pancreatic Homo sapiens 278-285 12153580-2 2002 With the aim to distinguish between local and global conformational changes induced by trifluoroethanol in RNase A, spectroscopic and activity measurements in combination with proteolysis by unspecific proteases have been exploited for probing structural transitions of RNase A as a function of trifluoroethanol concentration. Trifluoroethanol 87-103 ribonuclease A family member 1, pancreatic Homo sapiens 270-277 12153580-3 2002 At > 30% (v/v) trifluoroethanol (pH 8.0; 25 degrees C), circular dichroism and fluorescence spectroscopy indicate a cooperative collapse of the tertiary structure of RNase A coinciding with the loss of its enzymatic activity. Trifluoroethanol 18-34 ribonuclease A family member 1, pancreatic Homo sapiens 169-176 10449045-1 1999 The effect(s) of TFE (2,2,2-trifluoroethanol) on three different conformational states (native, denatured, and carboxymethylated) of CTX III and RNase A has been examined. Trifluoroethanol 17-20 ribonuclease A family member 1, pancreatic Homo sapiens 145-152 10449045-1 1999 The effect(s) of TFE (2,2,2-trifluoroethanol) on three different conformational states (native, denatured, and carboxymethylated) of CTX III and RNase A has been examined. Trifluoroethanol 22-44 ribonuclease A family member 1, pancreatic Homo sapiens 145-152