PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9377092-2 1997 When the substituent at C-4 of the tetrahydropyridine moiety is a carbamoyloxy functionality, the resulting dihydropyridinium metabolite undergoes spontaneous hydrolytic cleavage to yield 1-methyl-5,6-dihydro-4-pyridone, CO2, and the corresponding secondary amine. Pyrrolidines 35-53 complement C4A (Rodgers blood group) Homo sapiens 24-27 19421309-2 2008 Reaction of electrophiles with 3-oxo pyrrolidine dianions readily introduces substituents, regioselectively at C-4 in these pyrrolidines. Pyrrolidines 124-136 complement C4A (Rodgers blood group) Homo sapiens 111-114 31508886-1 2019 Amino-acid-derived phosphine catalyzed [4+2] cycloaddition leading to chiral tetrahydropyridines, making use of alpha-substituted allenic ketones as "C4 synthons" and N-sulfonyl cyclic ketimines, has been developed. Pyrrolidines 77-96 complement C4A (Rodgers blood group) Homo sapiens 149-152 1447747-5 1992 In this paper we report the results of synthetic and metabolic studies on a series of tetrahydropyridine analogs of MPTP with oxygen, sulfur, and carbamoyloxy derivatives on C-4 which serve as model compounds to evaluate the scope of this prodrug concept. Pyrrolidines 86-104 complement C4A (Rodgers blood group) Homo sapiens 174-177