PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 674296-0 1978 Protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase by fluostigmine. pyridine 38-48 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 435080-5 1979 The oximes with a hydroxyiminomethyl group in position 4 in the pyridinium ring were good reactivators of both phosphorylated and phosphonylated acetylcholinesterase. pyridine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-165 35221376-2 2022 In vitro studies revealed that the phenyl moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of electric eel AChE. pyridine 98-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. pyridine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 674296-1 1978 The protective effects of a series of new pyridinium derivatives against inhibition of acetylcholinesterase (AChE) by fluostigmine was studied in vitro on human erythrocytes. pyridine 42-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 33638151-1 2021 We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord). pyridine 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 58-72 1036947-3 1976 In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE). pyridine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 164-184 1036947-3 1976 In this case the formal insertion of an ethylenic double bond between the pyridinium ring and the aldoxime group decreases the ability to reactivate phosphorylated acetylcholinesterase (AChE). pyridine 74-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 33991570-3 2021 Herein, we explored the potential inhibitory activities of various pyridine, quinoxaline, and triazine derivatives (3a-k, 6a-j and 11a-h) against AChE and BuChE enzymes by following the modified Ellman"s method. pyridine 67-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 146-150 33638151-1 2021 We detail here distinctive departures from lead classical cholinesterase reactivators, the pyridinium aldoximes, to achieve rapid CNS penetration and reactivation of AChE in the CNS (brain and spinal cord). pyridine 91-101 acetylcholinesterase (Cartwright blood group) Homo sapiens 166-170 31585263-3 2019 Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. pyridine 38-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 31139552-6 2019 These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity. pyridine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 138-158 30978400-0 2019 Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. pyridine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 31139552-6 2019 These results allowed us to establish that pyridine substituent remarkably influences activation energy and reaction yield, as well as in acetylcholinesterase (AChE) activity. pyridine 43-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 29031067-0 2017 New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation. pyridine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 42-62 29735900-2 2018 For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives. pyridine 64-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 29131470-0 2018 Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles. pyridine 24-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-193 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridine 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-209 27581632-1 2016 A series of pyridinium salts bearing alkylphenyl groups at 1 position and hydrazone structure at 4 position of the pyridinium ring were synthesized and evaluated for the inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. pyridine 12-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 211-215 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. pyridine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 25453812-1 2014 Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE). pyridine 50-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 122-126 25218671-4 2014 The pyridine ring containing alkylated sulfonium species, dimethyl(pyridin-2-yl)sulfonium (2), reduced the free energy of activation by 4.4kcal/mol compared to the previously reported alkylating agent N-methyl-2-methoxypyridinium species (A) for the alkylation of aged AChE-OP adduct. pyridine 4-12 acetylcholinesterase (Cartwright blood group) Homo sapiens 269-273 23445881-13 2013 CONCLUSIONS: In this study, we presented a new series of benzofuranone-based derivatives having pyridinium moiety as potent dual acting Acetylcholinesterase/Butyrylcholinesterase inhibitors. pyridine 96-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-156 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. pyridine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 76-96 23148598-1 2012 Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents. pyridine 0-10 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-102 23073222-7 2012 MIFs calculated with the N1 (pyridinium nitrogen) and the DRY GRID probes in the AChE active site enabled us to establish the relationship between amino acid residues within AChE active site and the variables having high impact on models. pyridine 29-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 174-178 21787634-1 2010 Two newly developed AChE reactivators possessing two oxime groups in 4-position of the pyridinium rings with linkers CH(2)O(CH(2))(2)OCH(2) and CH(2)O(CH(2))(4)OCH(2) were tested for their potency to reactivate VX-inhibited AChE. pyridine 87-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 20546883-5 2010 The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS. pyridine 30-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 294-298 18617161-3 2008 For the recovery of inhibited AChE, derivatives from the group of pyridinium or bispyridinium aldoximes (called oximes) are used. pyridine 66-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 16828550-1 2006 New bis-pyridinium oxime reactivators connected with CH2O(CH2)n OCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. pyridine 8-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-190 17960099-2 2007 This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. pyridine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 17960099-2 2007 This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. pyridine 112-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 11831902-5 2002 Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. pyridine 31-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 16198581-0 2006 Search for dual function inhibitors for Alzheimer"s disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity. pyridine 133-143 acetylcholinesterase (Cartwright blood group) Homo sapiens 98-118 16198581-4 2006 [Scarpini, E.; Scheltens, P.; Feldman, H. Lancet Neurol.2003, 2, 539] In view of the development of new AChE inhibitors as drugs capable of reducing the symptoms of AD, the capacity of newly synthesized AChE inhibitors of pyridinium-type to inhibit the AChE was examined and compared to those of other inhibitors of this type presented earlier. pyridine 222-232 acetylcholinesterase (Cartwright blood group) Homo sapiens 104-108 16198581-10 2006 Pharmacol.2003, 55, 1397] Furthermore, the anti-Abeta fibril formation property of AChE inhibitors of pyridinium- and bispyridinium-type was evaluated to expand their activity profile and to reveal potential additive pharmacological effects which may reinforce their therapeutic application besides their capacity of increasing acetylcholine levels. pyridine 102-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 8343989-1 1993 Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE. pyridine 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-122 10488245-0 1999 Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme. pyridine 48-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 8343989-1 1993 Two pyridinium and two imidazolium dioximes were tested as reversible inhibitors of human erythrocyte acetylcholinesterase (AChE), as protectors of the enzyme against phosphorylation and as reactivators of the phosphorylated AChE. pyridine 4-14 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128