PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10805063-2 2000 It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform. pyridine 59-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-163 11774366-8 2001 Thus, the addition of a pyridine ring to NPYR or NPIP altered the forms of CYP primarily responsible for mutagenic activation. pyridine 24-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-78 10805063-2 2000 It is now commonly agreed that the oxidation of 1,4-dihydropyridine into pyridine, which is one of the main metabolic pathways, is catalysed by the cytochrome P450 (CYP) 3A4 isoform. pyridine 59-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 165-168 2061924-1 1991 A series of 21 different 4-substituted 2,6-dimethyl-3-(alkoxycarbonyl)-1,4-dihydropyridines was considered with regard to oxidation to pyridine derivatives by human liver microsomal cytochrome P-450 (P-450). pyridine 82-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 182-198 3327676-14 1987 The first step in the metabolism involves oxidation to the corresponding pyridine derivative by the cytochrome P-450 system. pyridine 73-81 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 100-116 182488-8 1976 This supports the model that one of the pyridine nitrogens of metyrapone is coordinated to the iron of cytochrome P-450. pyridine 40-48 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-119